Stuart Buck @stuartbuck1

Executive Director, Good Science Project Formerly: @arnold_ventures, @harvard_law, @kellogghansen Classical guitarist and author newsletter.goodscienceproject.org Georgia Joined June 2011

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Stuart Buck @stuartbuck1

13 hours ago

@majamediaco sure! i'm just saying that in year 2 of dealing with this with multiple kids, you will be overjoyed if your partner helps out at night even if he likes Nickelback. :)

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sure! not the same as children per se, but a long road trip could reveal many things about compatibility: * can we semi-agree on what music or podcasts to listen to? * can we adjust to each other's patterns of food and bathroom breaks? * how do we handle stressful situations like an unforeseen traffic jam that makes us an hour late getting to the hotel, or a hotel clerk that can't find our reservation? and most importantly, * can we simply find joy in being together for 10 hours straight? [if not, look out . . . ]

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Stuart Buck @stuartbuck1

14 hours ago

@majamediaco your long-term happiness depends infinitely more on those kinds of questions than on questions like "do we both like Tame Impala?"

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Stuart Buck @stuartbuck1

14 hours ago

one of the best predictors (I think) of relationship success is "how does this person behave when there is work that we have to do in a stressful situation?" Among a thousand examples: "our 6 month old just woke up at 3 am vomiting all over the crib, and now we have to wake up and deal with a bath, and laundry, and cleaning up the crib . . . is my partner someone who 1) helps out at all?!, and who 2) takes it all in stride?! or is he/she someone who never helps, or who only helps while complaining endlessly and making everything worse?" Try to predict *that* from an app.

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Stuart Buck @stuartbuck1

24 hours ago

@noampomsky did you mean "not found" in the first part?

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Lukas (computer)🔺 @SCHIZO_FREQ

4 days ago

I knew this guy who would always schedule in “EST” and then be late and I eventually ribbed him about it and he revealed that he thought “est” meant “estimated,” as in “the meeting time is an estimate and I may be 15 minutes late”

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tuomo @7uomoki

3 days ago

The central problem of biology is the origin of biological organization. In our preprint, “Information-theoretic Limits on Programmatic Specification of Biological Systems,” we show, using information theory, that an organism does not contain enough organism-specific information to specify its own fully functioning microscopic organization. For over 70 years—since the discovery of the double helix and the cracking of the genetic code—biology has been dominated by the metaphor of the genome as an executable computer script or structural blueprint. Yet, it has remained a central mystery how the genome organizes the entirety of the microscopic, fine-scale molecular biological machinery in space and time. We wish to put forward a radically different formulation. We show, as an analogy, that the genome is not a figure-skating program choreographing every molecular movement, but a hockey coach’s game plan : roster, tactics, line assignments. The exact trajectory of the puck is computed by physics at runtime. The game looks like hockey because of the specified ensemble, not because every coordinate was pre-programmed. The organized machinery of life is not the execution of a fully prewritten organism-specific program under favorable conditions. Rather, it is the compilation of a coarse organism-specific specification by a shared physical background that is constitutive of biological organization. We establish the threshold as a family of maximal capacity-compatible coarse-grainings, distinguish the proven impossibility below the threshold from the empirically realized coarse mappings above it, and locate the threshold empirically through worked cases of protein folding, E. coli, Drosophila early development, and C. elegans, together with computational verification using AlphaFold-2 (analyzing tertiary structures of 555,846 proteins across 46 AlphaFold-2 proteomes), the JCVI-syn3A 4D whole-cell simulation, and canonical stochastic gene network models. We further show that no known naturally realized environmental channel can close the gap. The result rules out programmed microstate determinism while leaving physical determinism untouched, reframes the genome as a generator specification rather than a trajectory program, and unifies gene-centric, developmental, and field-theoretic (bioelectric, morphogenetic, and related continuum) views of biological specification under a single coarse-graining framework. It has not escaped our notice that this framework has fundamental implications for understanding evolutionary search, heritability, thermodynamic order, biological modeling, and artificial intelligence in biology, but these will be published elsewhere. biorxiv.org/content/10.648…

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Stuart Buck @stuartbuck1

2 days ago

@calphabetsoup True, I love it! I know his sister-in-law and probably many others at the wedding.

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Stuart Buck @stuartbuck1

3 days ago

@SeveredLegs @brookeleblanc Not bad at all! Here is me performing live (at my college senior recital): youtube.com/watch?v=hqCTyg…

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Stuart Buck @stuartbuck1

3 days ago

Logging into Chase: ID and password. Works every time. Logging into pay my car loan: ID, password, and then this (as if a scammer is going to make an extra payment for me)

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Stuart Buck @stuartbuck1

4 days ago

After clicking about 20 times and then entering various codes sent to my email, I am finally able to spend a few dollars buying a pair of pants. Not sure why this has to be 100 times harder than logging into my literal bank account.

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Stuart Buck @stuartbuck1

4 days ago

Why oh why do websites that are trying to sell things default to this error message, instead of going straight to a page where I can quickly log in?

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Stuart Buck @stuartbuck1

3 days ago

@SeveredLegs @brookeleblanc no problem, I know what it looks like. :)

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Stuart Buck @stuartbuck1

3 days ago

This has to be one of the most EA/Less Wrong-coded weddings of all time: wsj.com/finance/leopol…

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Molly Mielke McCarthy @mollyfmielke

3 days ago

mark my words, intuition will be the new taste

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Zac Hill @zdch

3 days ago

Like two or three weeks ago I jumped into one of @stuartbuck1's threads being like "this is cool, but is there like a taxonomy of R&D orgs or e.g. that make sense of all these hypothetical landscapes and mechanics we're talking about?" He was like <grinning USA meme>. Well:

aishwarya🍎 @aishdoingthings

3 days ago

the white house OSTP report cited a forthcoming piece of ours – it is out now! a taxonomy of R&D orgs: analogue.press/p/a-taxonomy-o… as billions move toward new scientific institutions, we must rethink how R&D can be organized. @jainhiya_ @stuartbuck1

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aishwarya🍎 @aishdoingthings

3 days ago

Andrew Curran @AndrewCurran_

2 weeks ago

In an new report expected to be released later today the Trump administration will argue that directing federal funding towards individual researchers, and research that uses AI, will accelerate scientific progress faster than funding collages and universites.

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Stuart Buck @stuartbuck1

3 days ago

@SeveredLegs @brookeleblanc she's a friend in real life!

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Stuart Buck @stuartbuck1

4 days ago

@Amina_io I also liked his books Technopoly, The End of Education, The Disappearance of Childhood, and Building a Bridge to the 18th Century, but less a fan of Teaching as a Subversive Activity. I know I read Conscientious Objections at some point but can't really remember lol.