Juan David Flórez-Arango @juandfar
Medical Oncologist: Lung Cancer, Thymic Cancer, Head and Neck Cancer & Thyroid Cancer. Medellín - Colombia Medellín, Colombia Joined September 2012-
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#Investigación Junio de 2024. El presidente @petrogustavo es captado en Panamá de la mano de una mujer hasta ahora desconocida. Su nombre es Vanessa Cortés y desde que Petro es presidente, ha tenido un rápido crecimiento patrimonial. Va 🧵
High quality study from @BenjaminBesseMD showing only 26% of pts need retreatment after getting 2 yrs pembro for NSCLC. However, outcome for IO rechallenge was mixed, w/ many pts clearly not responding and dying. Much like CM-153 & w/ prior pooled report of Abreu-Rodriguez showing only 19-27% ORR with pembro re-challenge. So still an unresolved question: whether 2-yr discontinuation is optimal for all patients? @GustaveRoussy
After discontinuing pembrolizumab among patients with advanced #NonSmallCellLungCancer survival outcomes were high and subsequent immunotherapy use was rare. ja.ma/3OatlKo
🫁 CheckMate 743: 5-Year Survival Update. In unresectable pleural mesothelioma, first-line nivolumab plus ipilimumab maintains OS benefit vs chemotherapy at 66.8 months. 5-year OS: 14% vs 6%, HR 0.74 (95% CI 0.62–0.88) Adjusted for 24% crossover: HR 0.64 (95% CI 0.53–0.78). High baseline M-MDSCs associated with worse OS (HR 1.25). No new safety signals. 📖 @JCO_ASCO DOI 👉🏻 doi.org/10.1200/JCO-25… #CánCare #Mesothelioma #Immunotherapy #ICI #ThoracicOncology
Induction chemo-immunotherapy followed by chemo-radiotherapy and immunotherapy maintenance in stage III NSCLC (APOLO): a phase 2 trial | Nature Communications nature.com/articles/s4146…
Great review @JTOonline on the latest breakthroughs for non-V600E BRAF NSCLC patients, led by @SandraOrtizCua1 within our #BOLEROconsorti. Join our efforts to advance lung BRAF research! 🚀 #Oncology #BRAF #lungcancer
Nicolás Maduro es digno sucesor de Hugo Chávez y trabajará también por la Paz en Colombia.
Trastuzumab Deruxtecan monotherapy benefit (cORR:44.4% and mPFS: 8.2mo) confirmed in pretreated HER2-overexpression (IHC 3/2+) NSCLC pts (Results Part 1 of Phase 1b DESTINY- Lung03 Trial) @JTOonline
🫁 1L immunotherapy vs targeted therapy in BRAFV600E-mut NSCLC (FRONT-BRAF). In BRAFV600E-mutated metastatic NSCLC, first-line immunotherapy (± chemo) improved OS vs BRAF+MEK inhibitors (40.9 vs 25.2 mo). Benefit was greater in PD-L1 ≥1%, TP53 co-mut, smokers, and ≥70y. 📖 @TheLancetOncol DOI 👉🏻 10.1016/S1470-2045(25)00409-7 #CánCare #NSCLC #lungcancer #immunotherapy #BRAF #MEK #ICI #oncology
🚨Update in Head&Neck SCC @NCCN Evidence Blocks 💉neoadjuvant #pembrolizumab added! Highlighting indication for resectable stage III/IVa CPS+, excluding N3 💉Sc R/M #nivolumab (review new doses 600mgQ2W/1200mgQ4W) 👇v5 Pics @OncoAlert @brunolarvol @BAHNOOfficial @ttccgroup
🚨 NSCLC & ICI Resistance Mutations inKEAP1,SMARCA4 & PTEN reshape TME → driving poor responses to ICIs 📉 Even wth high PD-L1/TMB, outcomes remain dismal. ⚠️ The triple-mutant group (KRAS+KEAP1+STK11) shows the worst resistnce & prognosis rdcu.be/eB5gC
🚨 #Lungcancer survival has more than doubled. New real-world data from France shows 3-year survival for lung adenocarcinoma rose from 16.3% (2000) to 38.6% (2020) driven by earlier diagnosis & targeted treatment. This is what progress looks like. But it must reach everyone who needs it. 🔗 @NEJMEvidence June 2025 evidence.nejm.org/doi/full/10.10… #LCSM
BREAKING from @NEJM In cancer patients w/ Cancer-Associated Venous Thromboembolism, reduced-dose apixaban (2.5 mg BID) is : 🔘Noninferior to full-dose (5 mg BID) for VTE recurrence 🔘Lower bleeding risk (12.1% vs. 15.6%) 🔘Safer extended anticoagulation, same protection. #Thrombosis #cancer @OncoAlert @Cihan_Ay_MD DOI: 10.1056/NEJMoa2416112
YES! De-escalation trials matter and should be much more supported by payers! Very preliminary results from the Dutch non inferiority trial DEDICATION-1 are reassuring. In France, the PULSE trial has the same hypothesis, opens soon in Belgium, Spain, Estonia and Greece! #ESMO24
New article in press: Gemcitabine, carboplatin, and Epstein Barr virus-specific autologous cytotoxic T lymphocytes for recurrent or metastatic nasopharyngeal carcinoma: VANCE, an international randomized phase 3 trial. doi.org/10.1016/j.anno…
📣 The new ESMO Living Guideline on Oncogene-Addicted Metastatic Non-Small-Cell Lung Cancer is now online. 🔗 ow.ly/aWHx50SBy3O
Stop pembro after 2 years? In 43,359 pts that received up-front pembrolizumab for an advanced NSCLC, continuation beyond 2 years was not associated with better OS than a fixed 2-year treatment, HR = 0.97 [0.75–1.26] p = 0.95. @arousseaumd sciencedirect.com/science/articl…
Presented at #ASCO24: Among patients who received two 3-week cycles of neoadjuvant ipilimumab and nivolumab, the 12-month event-free survival was 83.7%, as compared with 57.2% among those who received only adjuvant therapy. Full NADINA trial results: nej.md/3wSo3uk
Press release: phase III ADRIATIC study of durvalumab after chemoradiation for limited stage #SCLC improves both PFS and OS. Follows the PACIFIC approach, randomizing after definitive chemoradiation. Await data on durva + tremelimumab arm. #LCSM astrazeneca.com/media-centre/p…
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