Agnes Noy @ANoyLab
Agnes Noy research account: Professor at the University of York. DNA, biophysics, modelling, supercoiling, and much more. Active in @agnesnoy.bsky.social agnesnoylab.wordpress.com York, UK Joined April 2019-
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Thanks for sharing our work! See below a movie done by computer simulations capturing the #DNAzipping youtube.com/shorts/mvT-aK3…
🧬 For the first time, scientists have directly captured DNA molecules “zipping” together. Positively charged metal ions appear to act as tiny molecular bridges, helping negatively charged DNA helices overcome repulsion and align with remarkable precision. A fascinating look at
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Happy to see that our work is being divulged! 🙂The original work: academic.oup.com/nar/article/54…
Scientists have discovered how DNA molecules overcome their natural electrical repulsion to pair together. Tiny metal ions act as molecular bridges, supporting a 20-year-old “DNA zipper” theory and offering new clues about cancer and biotechnology.
Agnes Noy retweeted
Scientists have discovered how DNA molecules overcome their natural electrical repulsion to pair together. Tiny metal ions act as molecular bridges, supporting a 20-year-old “DNA zipper” theory and offering new clues about cancer and biotechnology.
By combining high-resolution AFM with all-atom MD simulations, we observe groove-to-groove alignment between the 2 DNA duplexes mediated by ionic bridges youtube.com/shorts/ivy_Qh-…
How do DNA duplexes recognize and pair with each other? Thomas Catley, @VVBerrelleza, @alicepyne and myself present the first direct visualization of DNA-DNA pairing mediated by divalent cations, confirming the decade-old DNA zipper model! doi.org/10.1093/nar/gk…
Agnes Noy retweeted
Congrats to @JamiesonH - our latest @PhysLifeYork work dissecting the structural landscape of the Rep Helicase is now in Nucleic Acids Research! Huge team effort! @Craggs_Lab @AllisonHSquires @ANoyLab @BPSIYork @mahmoud @DrM_Abdelhamid @Single_Mole 👇 tinyurl.com/bdznxur3
Come to York and fight antimicrobial resistance with Daniel Cole, @dghilarov and Inspiralis Ltd. MRC DiMeN Doctoral Training Partnership: Computational Drug Discovery Targeting DNA Gyrase to Tackle Antimicrobial Resistance at University of York on FindAPhD.com
Overall, HU binds DNA in a multi-step process: electrostatic interactions build up gradually until the protein locks onto its target site. This prevents HU from sticking to random DNA along the way.
The switch to high-affinity HU–DNA binding happens only at the target site, helped by DNA’s own flexibility. It suggests a concerted mechanism, bridging the gap between “induced fit” and “conformational selection.”
Check our latest publication in #JACSAu @ACSPublications with @ElliotWChan and @BPSIYork where we describe how the bacterial protein HU binds DNA at atomic resolution. Thanks to @EPSRC and @N8CIR and @hecbiosim for computational resources. See more👇pubs.acs.org/doi/10.1021/ja…
Agnes Noy retweeted
Gave my first talk at the @UniOfYork Grateful to @BPSIYork & @ANoyLab for the opportunity, and to my supervisor @joshiphy for his constant support. It was a truly enriching experience to share my work and interact with such inspiring researchers. Also thnks to @SonamRagha77827
Agnes Noy retweeted
📢 Our article calling for a #FAIR database for #MolecularDynamics simulation data has now been peer-reviewed and published in @naturemethods 📖 Read it here: rdcu.be/ef6YX 📝 Support the statement: bit.ly/3zVS3qm #MDDB #FAIRdata #collaboration
Looking forward to attending this meeting and having interesting discussions about ai vs physics-based modelling approaches 🙂
Biophysics, Stat Mech and Machine Learning will meet in Trento from July 7th to 11th, 2025 in our StatPhys29 Satellite Workshop "Molecular biophysics at the transition state: from statistical mechanics to AI": indico.ectstar.eu/event/252/. Co-organized with @ai_ngrosso.
Agnes Noy retweeted
🚨🚨Please RT! 📢📢 Still time to submit short talk abstract for EdinPBS2025! Five themes this year: · Mechanobiology · Protein pattern formation · 4D Genome · Stochastic biology · Biohydrodynamics bit.ly/EdinPBS2025
This is one of the conferences where I have genuinely learned more. Delighted to contribute to this vision article.
An article talking about ‘Future directions of the prokaryotic chromosome field’. This vision article resulted from of a workshop organized at @lorentzcenter onlinelibrary.wiley.com/doi/10.1111/mm…
Agnes Noy retweeted
Fundamental research into DNA “bubbles” will improve scientists' understanding of how genetic programs unfold to help in disease detection and treatment @ANoyLab tinyurl.com/3ewa2yz7
Were you interested in our last paper in @PhysRevLet but found it too complex to follow? Then look at this article by @physorg_com, where it is explained in plain terms phys.org/news/2025-02-m…
Thrilled that the paper has just appeared in @PhysRevLett. Excellent work from Matt Burman's @EPSRC -funded PhD. Thanks to @N8CIR and @hecbiosim for computational resources. Check the updated thread in @agnesnoy.bsky.social! journals.aps.org/prl/abstract/1…
📢 Preprint alert: How the structure of linear DNA is distorted by physiological levels of torsion and tension? 🧬🧬 The answer by all-atom simulations and it is similar from what we saw on minicircles with @alicepyne 👇(1/n) biorxiv.org/content/10.110…
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