Bruce Levine, Ph.D. 🇺🇦🥼🔬🧬🧪💉 @BLLPHD
Professor @Pennmedicine We create #CellTherapy #Genetherapy - Tmunity (Kite) & Capstan (Abbvie) CoFounder, Past President @ISCTGlobal, @PNASNexus AE med.upenn.edu/cvpf/ Philadelphia, PA Joined November 2010-
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@HenrychihangFu1 Stay tuned, I'll post more on longer term clinical outcomes tomorrow
And with links: June and Sadelain Prizes 2026 BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine frontiersofknowledgeawards-fbbva.es/noticias/18th-… 2026 Tang Prize in Biopharmaceutical Science prnewswire.com/apac/news-rele… 2026 Ross Prize in Molecular Medicine feinstein.northwell.edu/news/the-lates… 2025 Broermann Medical Innovation Award broermann-award.org/broermann-medi… 2025 Merkin Prize in Biomedical Technology merkinprize.org/2025-merkin-pr… 2024 VinFuture Prize or Innovators with Outstanding Achievements in Emerging Fields for development of CAR T cell therapy for cancer and other diseases vinfutureprize.org/news-insights/… 2024 Warren Alpert Foundation Prize for pioneering applications of chimeric antigen receptors to engineer T cells for adoptive immunotherapy of cancer and autoimmunity warrenalpert.org/prize-recipien… 2024 Breakthrough Prize in Life Sciences - For the development of chimeric antigen receptor T cell immunotherapy whereby the patient’s T cells are modified to target and kill cancer cells breakthroughprize.org/Laureates/2/P1… 2021 American Society for Gene and Cell Therapy Outstanding Achievement Award asgct.org/awards/honorif… 2018 Passano Foundation Physician Scientist Awards passanofoundation.org/services 2012 William B. Coley Award for Distinguished Research in Basic and Tumor Immunology cancerresearch.org/william-b-cole…
As CAR T applications, approvals, and patients treated have increased, so have the award citations to Carl June and Michel Sadelain. The list so far: 2026 BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine 2026 Tang Prize in Biopharmaceutical Science 2026 Ross Prize in Molecular Medicine 2025 Broermann Medical Innovation Award 2025 Merkin Prize in Biomedical Technology 2024 VinFuture Prize or Innovators with Outstanding Achievements in Emerging Fields for development of CAR T cell therapy for cancer and other diseases 2024 Warren Alpert Foundation Prize for pioneering applications of chimeric antigen receptors to engineer T cells for adoptive immunotherapy of cancer and autoimmunity 2024 Breakthrough Prize in Life Sciences - For the development of chimeric antigen receptor T cell immunotherapy whereby the patient’s T cells are modified to target and kill cancer cells 2021 American Society for Gene and Cell Therapy Outstanding Achievement Award 2018 Passano Foundation Physician Scientist Awards 2012 William B. Coley Award for Distinguished Research in Basic and Tumor Immunology
Carl June and Michel Sadelain have shared at least 10 major prizes for developing CAR T cells since 2012
Perseverance, Persistence Key to CAR T Success, Say Ross Prize Winners Carl June and Michel Sadelain During the award ceremony, both scientists spoke on the many benefits of and future directions for #CARTcells @carlhjune @ColumbiaMed #immunotherapy #HIV hubs.li/Q04lSyP-0
Clinical CGT Applications Program for Fellows from @ISCTglobal Oct 26–27, 2026 at Penn Medicine Forty fellows. Two days. One community that lasts a career. A fully funded clinical immersion for fellows who will be selecting, prescribing, and operationalizing cell and gene therapies in hematology/oncology, transplantation, and immune-mediated diseases. Applications due July 31. Know a fellow who belongs in this room? isctglobal.org/workforce-deve…
Philosophically I find it interesting, and we had suspected, that it is not the size of the missile (CAR T with CD28 domain), but this paper shows asymmetric division lets one cell clone pursue two strategies simultaneously: fight now and remember later (CAR T with 4-1BB domain).
NEW - Fate induction through asymmetric T cell division is modulated by chimeric antigen receptor costimulatory domains Why do 4-1BB CARs often persist better than CD28 CARs? It is not simply signal strength. It is signal quality and fate programming after the first asymmetric T-cell division. CD28 CAR-T cells show stronger surface polarization, but 4-1BB drives deeper transcriptional, metabolic and epigenetic divergence, generating distal daughter cells with memory/persistence programs and better leukemia control in models. @NatImmunol Christoph Ellebrecht & colleagues @PennMedicine #TCell #CARTCell #immunotherapy nature.com/articles/s4159…
Gary Schwitzer is a treasure. If only science journalists and editors at the NY Post, Houston Chronicle, Dallas News, and others would listen. In this era, getting SciComms right is more important than ever.
Brain aging reversed by nasal spray?!? Rats…it’s only in mice. The headlines couldn’t squeak by us. garyschwitzer.substack.com/p/brain-aging-…
🧵 Important from FDA today -- a new, broad initiative to improve clinical trial efficiency with aim of maintaining 🇺🇸 biomedical edge over 🇨🇳. Reform entails a long series of small changes that, taken together, tilt the playing field back in US favor. This is a key start...
My list of global CAR T approvals. There is a trend to in country development and approvals. Any I've missed?
Important milestone for the field: CARsgen’s satri-cel, an autologous Claudin18.2 CAR T, has been approved in China for Claudin18.2+ HER2- advanced gastric/GEJ adenocarcinoma after ≥2 prior lines. CAR T has transformed blood cancers. Solid tumors have been the harder frontier: trafficking, persistence, antigen heterogeneity, and the tumor microenvironment. This approval does not mean the problem is solved, but it shows that engineered T cells can make it across the solid tumor line. Now the work turns to durability, safety, access, earlier lines, combinations, and whether this can extend to other Claudin18.2+ tumors. prnewswire.com/news-releases/…
🚨When are there going to be CARs for solid tumors? Now! An approval in China 👇
The United States ranks 13th in the amount it spends on academic research as a portion of its overall economy
The Science That Turned Lizard Venom Into GLP-1s Is Under Attack nytimes.com/2026/06/20/opi…
The Science That Turned Lizard Venom Into GLP-1s Is Under Attack nytimes.com/2026/06/20/opi…
@Jasonmmast Here's to FDA decisions grounded in science, not politics. These principles should not be on a pendulum, but should be consistently applied by Center and Agency Directors.
@Nfcanavan No, we have to recognize that each represents a team.
Also red wine
For cell and gene therapies, credibility matters. Patients, investigators, sponsors, and regulators need FDA decisions grounded in science, not politics. The best FDA is expert-led, evidence-based, transparent, and consistent across administrations. That is how we accelerate.
My editorial in JAMA Health Forum on restoring FDA's strength. 'The periods of greatest credibility--and greatest administrative and legislative success--have coincided with strong career leadership in the centers paired with effective commissioners' @AEI jamanetwork.com/journals/jama-…
RFK Jr: "Gardasil is probably the single worst mass vaccine that we've ever seen The reality It's SO GOOD that no one vaccinated in England has died from cervical cancer. In fact it's on the way to eliminating it. Yes - ELIMINATE CERVICAL CANCER Don't listen to RFK Jr
#Philly #CelliconValley moves up to 5th 🧬🧪🧑🔬 #celltherapy #genetherapy #biotech
Top 10 U.S. Biopharma Clusters 2026 GEN's @AlexWestchester presents his latest edition of its nationally and regionally-cited annual A-List of its top 10 U.S. biopharma cluster rankings #GENindustrynews #biopharma #clinicaltrials hubs.li/Q04lSWBk0
Brad Loncar @bradloncar
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Adam Feuerstein ✡�... @adamfeuerstein
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ASH @ASH_hematology
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Paul D. Rennert @PDRennert
6K Followers 474 Following Co-founder, President & CSO, Aleta Biotherapeutics, https://t.co/vyLXDleOdp - Founder & Principal, SugarCone Biotech, commentary at https://t.co/nE18E8qx8B
Evan Weber @EvanWeberPhD
3K Followers 653 Following Assistant Professor @PennMedicine @ChildrensPhila | CAR T, cancer immunotherapy, T cell fitness | https://t.co/aRpyzfCH0r
Journal for ImmunoThe... @jitcancer
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lino @ljiqfb
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Saman Sarraf 😷 @SamanSarraf
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0 Followers 25 Following was fascinated by biology 🧫 and want to do something big in this field and i think bio technology and bioinformatics are the right path.
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Jan Vincent Beltran, ... @levin_beltran
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Adam Feuerstein ✡�... @adamfeuerstein
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David R. Liu @davidrliu
79K Followers 68 Following Professor at Harvard and the Broad Institute. Our lab integrates chemistry & evolution to illuminate biology & enable new therapeutics. IG/Threads: @davidrliu1
Bertrand Delsuc @BertrandBio
19K Followers 234 Following Views=mine only, RT-like=/=endorse, no advice. 16y in Tech (chip design) & 10y following bios. Preplanned pause.
Jacob Plieth @JacobPlieth
33K Followers 285 Following Journalist @ApexOnco. The Wolverine Of Biotech / Mr ASH. Never paid for a blue tick. Interested in: oncology. Not interested in: what stock you bought today.
David Steensma, MD @DavidSteensma
27K Followers 454 Following Hematologist-oncologist. @AjaxThx CMO. Former Edward P. Evans Chair in MDS @DanaFarber, @HarvardMed & @MayoClinic faculty, @NovartisScience hematology head.
Andrew Pannu @andrewpannu
15K Followers 297 Following daily dose of biotech & healthcare commentary • founder @sleuthinsights • building software for the bioeconomy
Daphne Zohar @daphnezohar
27K Followers 797 Following Founder, Board & CEO of @SeaportTX. Co-founder Karuna Tx (now at BMS). previously Founder, Board & CEO PureTech. Cofounder/host @BiotechCH.
Krishna Komanduri, MD... @drkomanduri
13K Followers 4K Following Physician in Chief @UCSFCancer; Chief Hem/Onc @UCSFHealth; @ASTCT Past-President. Father of four, husband, shutterbug, aspiring pizzaiolo. Views here mine only.
Fyodor Urnov @UrnovFyodor
38K Followers 504 Following Gene editor + Professor Molecular Therapeutics @berkeleyMCB + Director for Technology and Translation @igisci + @danahercorp Beacon for CRISPR Cures.
Matthew Herper @matthewherper
111K Followers 3K Following Writing and events at STAT. This is biology's century; Every data point has a face. ‘21 Polk Award. Signal: MattHerper.92
Peter Kolchinsky @PeterKolchinsky
64K Followers 184 Following Managing Partner, RA Capital Management. We build & invest in biotech companies. Scientist. Author, The Great American Drug Deal. https://t.co/ARVLrrTQU4
Paul D. Rennert @PDRennert
6K Followers 474 Following Co-founder, President & CSO, Aleta Biotherapeutics, https://t.co/vyLXDleOdp - Founder & Principal, SugarCone Biotech, commentary at https://t.co/nE18E8qx8B
Evan Weber @EvanWeberPhD
3K Followers 653 Following Assistant Professor @PennMedicine @ChildrensPhila | CAR T, cancer immunotherapy, T cell fitness | https://t.co/aRpyzfCH0r
John Carroll @JohnCendpts
71K Followers 109 Following Capped a 48-year journalism career with a decade-long (and counting) run as founding editor at Endpoints News. Writing a book on cancer care in America: Stage 4
Dr. Patrick Hwu @PatrickHwuMD
27K Followers 2K Following Moffitt Cancer Center President and CEO, @MoffittNews. Tumor immunologist. Inspired leader. Girl dad. #DocsWhoRock. Driven to save more lives from #cancer.
Alliance for Regenera... @alliancerm
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ASGCT @ASGCTherapy
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Biotech Hangout @BiotechCH
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359K Followers 499 Following Board Certified FM Doctor in NYC/NJ 🏥 30+ Million Followers Strong 📩[email protected]
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5K Followers 3K Following Writing about science, medicine & business for @statnews Email me: [email protected]
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17K Followers 2K Following @statnews reporter / [email protected] / Signal: damiangarde.67
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2K Followers 1K Following reporting on drugs and biotechs @endpts • email me: [email protected] • Signal: leileiwu.24 • ✌️
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28K Followers 3K Following Progress in science depends on new techniques, new discoveries and new ideas, probably in that order - {Sydney Brenner}. I write about biotech @MIT @techreview
Principles First @Principles_1st
29K Followers 2 Following A grassroots effort to rediscover and champion principles in the 21st century #PrinciplesFirst
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Broad Institute @broadinstitute
100K Followers 3K Following A multidisciplinary community of researchers on a mission to improve human health.
John Connolly @John_E_Connolly
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ImmunoACT @ActImmuno
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BowTiedBiotech 🧪�... @BowTiedBiotech
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Rebecca Skloot (she/h... @RebeccaSkloot
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Hank Greely @HankGreelyLSJU
8K Followers 26 Following I'm a Stanford law prof. I work on ethical, legal, and social issues in biosciences. My book CRISPR People came out in Feb 2021, joining 2016's The End of Sex.
















