Bednar lab @BednarLab
Pancreatic cancer research, epigenetics, tumor immunology, tumor evolution, surgeons doing basic science, UM PanTErA, #NewPISlack, personal Twitter: @Fil_Bednar University of Michigan Joined August 2019-
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Anyone even remotely interested in tumor biology and metabolism should line up!
Looking for a postdoc position and attending AACR in San Diego? I'll be there, too, and the lab is actively recruiting! Send me an email with your CV and cover letter, and I’ll follow up if there is a mutual fit. See more about our research at airdlab.com.
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Bednar lab retweeted
In Memoriam: Professor Greg Hannon (1964–2026) cruk.cam.ac.uk/news/in-memori… cruk.cam.ac.uk/news/in-memori…
Really nice work highlighting the role of stroma-produced PAI-1 and tPA in the modulation of pancreatic cancer immune response by our colleague, Kyoung Lee! @UMICHpancreas science.org/doi/10.1126/sc…
@LyssiotisLab Agree! This is nuts! Combining synthetic biology with in vivo understanding to give an intervention like this!
Bednar lab retweeted
Biology is not static -- proteins are constantly being made, modified, and destroyed as cells live, respond, and adapt. Each cell interacts with other cells and its matrix to shape its proteome and dynamic responses. That’s why understanding in vivo proteome dynamics at the level of individual cells is one of the most exciting frontiers in understanding biological systems. 1/2
Bednar lab retweeted
Cover article of @CR_AACR by @Pasca_Lab @UMICHpancreas Wilms Tumor 1–Expressing Stromal Cells Promote Pancreatic Cancer Progression aacrjournals.org/cancerres/arti… Very nice study with autochthonous models to track the fate of WT1+ fibroblasts and impact of depletion on natural history.
Bednar lab retweeted
Preprint from @UMICHpancreas (Eileen Carpenter): Longitudinal analysis of matched patient biospecimens reveals neural reprogramming of Cancer-associated fibroblasts ("NR-CAFs") following chemotherapy in #PancreaticCancer biorxiv.org/content/10.648…
Bednar lab retweeted
I’m thrilled to introduce you to the NeuMap! our latest work in @Nature. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour-de-force 🗺️ @AndrsHidalgo16 nature.com/articles/s4158…
Bednar lab retweeted
Sharing our new preprint: In mice, lipid-rich diets prior to oncogenic Kras activation accelerate tumorigenesis and remodel epithelial-stromal plasticity and dynamics. Thanks to our outstanding co-first authors @kaur_urvinder and @erifaraoni biorxiv.org/content/10.110…
Bednar lab retweeted
Biology is not random. And so if you measure any aspect of it a lot of times and compare your data to a random model you will eventually rederive this fact. The problem with absurdly small p-values is that, because you can essentially always get them by juicing your sample size, when you see something like p < 10^-300 what it’s really saying is THAT biology is non-random, which we already knew, and not HOW it is non-random, which is what we really care about.
The first rule of Data Science - if your p-value is less than 1 over the number of atoms in the universe, you're using the wrong model.
Bednar lab retweeted
COLLECTION of papers on Spatial Transcriptomics of IPMNs (Cystic Precursor lesions of #PancreaticCancer): aacrjournals.org/clincancerres/… aacrjournals.org/cancerdiscover… aacrjournals.org/clincancerres/… science.org/doi/10.1126/sc… nature.com/articles/s4146… biorxiv.org/content/10.110… biorxiv.org/content/10.110…
Bednar lab retweeted
1/ You think your ML model fails because it’s “not powerful enough”? No. It’s your data. Garbage in, garbage out. Here’s what most AI scientists miss when using public RNA-seq or single-cell data 👇
Bednar lab retweeted
We're excited to kick off the 2nd annual PancMidwest Symposium. We'll have two days of presentations, posters and networking among pancreatic cancer researchers in the region.
@ProfBootyPhD @NikoMcCarty It comes down to scales and how information transfer happens across them. How do we go from single molecules and their physicochemical behavior to a functioning organism. That is to say I agree with you 💯. In my mind this is one of the most fundamental problems in biology.
Bednar lab retweeted
Kudos to @PanCAN for creating the SPARK data platform containing vast troves of clinical, imaging, laboratory & molecular data from Precision Promise and Know Your Tumor. Fabulous resource for #PancreaticCancer researchers in both academia and industry. @sdosssdoss
Bednar lab retweeted
PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.
Bednar lab retweeted
Abstract titles for the 2025 @AACR special conference on #PancreaticCancer in Boston are now online: aacr.org/wp-content/upl… Full program: aacr.org/meeting/aacr-s… #AACRPan25 Hope to see many of you there @ednacukierman @lauradelongwood @isteaus @lustgartenfdn @letswinpc
@slavov_n The emphasis on tumor immunosurveillance is interesting. Whatever carcinogenesis model gets put forth, it should take into account and be able to reflect the recent significant rise in young adult-onset cancers in some solid organs.
Bednar lab retweeted
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Daniel Bordom @dcbordom
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Joshua Elkington @elkingtonxy
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Simon Schwörer @schwoerersimon
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Macleod Lab - Univers... @LabMacleod
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Andrey Tvardovskiy @ATvardovskiy
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Mikala Egeblad @megeblad
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Alex Cagan @ATJCagan
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Diane M. Simeone, MD
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Giulia Biffi
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Kathy DelGiorno
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PitarresiPhD
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