ColnotLab @ColnotLab
We study the biology of stem/progenitor cells in musculoskeletal development, regeneration and diseases. colnotlab.com France Joined April 2021-
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Our new study is out today in BoneResearch @SpringerNature entitled "Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma". 👉 rdcu.be/dVqVp
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Today I was honored to present with Stavroula Kousteni the Meet-the-Professor session on Stem Cells ASBMR Task Force Report @ASBMR #ASBMR2024 Thanks to all the participants for a stimulating discussion
ColnotLab retweeted
Important discussions related to stem cells at the ASBMR meeting this morning. @ASBMR2024
This coordinated process is disrupted in musculoskeletal trauma leading to fibrosis and impaired healing. Modulating macrophage function decreased fibrosis and enhanced bone repair, revealing macrophages as a potential therapeutic target to treat trauma-associated fibrosis.
We report an immune cell atlas of bone regeneration. Using single-nucleus transcriptomics, we uncovered parallel inflammatory responses of macrophages and skeletal stem progenitor cells in the early stages of bone healing.
We would like to thank everyone involved in this study @Inserm @IMRB_Mondor @UPECactus @InstitutImagine and our funding support @AgenceRecherche @DeptofDefense @NIH_NIAMS @ANR_FRANCE @OTCFoundation
This work opens new therapeutic perspectives for patients with CPT. It also provides exciting new concepts on the role of the periosteum and Schwann cells in bone healing and fibrous nonunion.
Our latest publication is out in @ScienceTM. This study from @SimonPerrin15 and co-authors investigated a severe form of bone repair defect and found a very unexpected mechanism involving Schwann cells!
A postdoctoral position in musculoskeletal regeneration and stem cells is open in @ColnotLab #imrb #inserm #upec We look forward to receiving applications for this project integrating functional in vivo analyses, microscopy and single cell transcriptomics
@ChristianGoritz Congratulations to the whole team!
ColnotLab retweeted
Very excited to start 2024 by sharing our new study from @ColnotLab just out in @eLife In this study, we created a cell atlas of the periosteum and the fracture environment from 🐁 to unravel the differentiation trajectories of skeletal stem/progenitor cells during bone repair👇
Félicitations à @SimonPerrin15 qui a reçu le Prix de l'Université 2023 @valdemarne_94 pour sa thèse de doctorat réalisée @IMRB @UPECactus et @univ_paris_cite et qui a porté sur le rôle du périoste dans la régénération osseuse et la pseudarthrose congénitale de jambe.
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