Ellie Rand @EllieRand3

Harvard Systems Biology PhD in the @baym lab. Petitioning for a bacteria emoji Joined December 2019

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Michael Baym @baym

a year ago

The latest work from my lab, Phage Disco, a method @EllieRand3 developed for targeted discovery of bacteriophages based on the bacterial receptor, defense system, or other component they interact with, is now live in mSystems

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Phage Directory @phagedirectory

2 years ago

.@EllieRand3 (@harvardmed) etal developed a new targeted #Phage Discovery method based on multiple fluorescent markers, allowing for co-culture w/ multiple hosts & visualization of phages — no more selecting only for dominant phages in samples! buff.ly/41dkOdN

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Ellie Rand @EllieRand3

2 years ago

@Klebsi_Ella_R @implosian @baym @nquinoneso Thanks! We use regular LB Lennox for the phage screening experiments. We only use LB without salt when growing cells for transformations. It just makes it so we don't have to wash the cells as much before electroporation!

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Ellie Rand @EllieRand3

2 years ago

Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @implosian, @baym, @nquinoneso, Kesther and Carmen! biorxiv.org/content/10.110… 1/

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Michael Baym @baym

2 years ago

We've long been able to find new phages and figure out what they interact with. But what about the other way: if you have a gene, like an antibiotic resistance efflux pump, or a phage defense system, and you want to find phages that do or do not interact with it? Now you can!

Ellie Rand @EllieRand3

2 years ago

@implosian @baym @nquinoneso What if we dug into a sample a little more “wild” and a little less characterized? We combined our strains with a wastewater sample (thank you Boston for your ~contributions~), and we found fluorescent hits! Each was isolated and characteristics confirmed on monoculture lawns. 5/

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Ellie Rand @EllieRand3

2 years ago

@implosian @baym @nquinoneso Thank you so much to everyone who has worked on this project with us! It’s been so much fun to hear about the phages people are interested in isolating. We are so excited about the upcoming collaborations to put this method to good use! 9/9

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Ellie Rand @EllieRand3

2 years ago

@implosian @baym @nquinoneso Phage DisCo is a reliable way to target phage discovery. It can be modified to your chosen phage characteristics of interest by selecting which strains to screen on. The only requirements are genetic tractability of the bacterial host and an environmental sample to screen! 8/

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Ellie Rand @EllieRand3

2 years ago

@AkosNyerges Thank you!!

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Ellie Rand @EllieRand3

2 years ago

Very excited to add this financial support to the educational, research, and emotional support that my mentors, lab mates, friends, and family have provided throughout grad school <3

Michael Baym @baym

2 years ago

Huge congratulations to @EllieRand3 for receiving an F31 from NIAID to support her and her thesis project “Receptor-Guided Discovery of Environmental Phages” with me and @PaulTurnerLab!

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Ellie Rand @EllieRand3

2 years ago

@jasmijnbaaijens Thank you!! I miss you guys and hope you’re doing well!

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Ellie Rand @EllieRand3

2 years ago

@baym @PaulTurnerLab Thank you!!

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Siân Owen @implosian

3 years ago

Living the [phage biologist's] dream today, touring the legendary Deer Island wastewater treatment plant in Boston🥚🥚🥚

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Elizabeth Rand @LizRandLiverDoc

3 years ago

Having a great day visiting Boston and rubbing shoulders with @Baym in his lab (where my talented daughter is a PhD candidate 🙂❤️)

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Ellie Rand @EllieRand3

3 years ago

Check out this awesome work by @nquinoneso and @implosian on discovering and exploring the world of plasmid dependent phages! It was so fun to watch this project come together, and I learned so much from you guys along the way. Congratulations!!

Natalia Quinones-Olvera @nquinoneso

3 years ago

Exciting news! The pre-print for our paper, “Diverse and abundant viruses exploit conjugative plasmids” is finally out! Join me on this thread to hear more about this mysterious group of phages with rather unique lifestyle preferences. 1/ biorxiv.org/cgi/content/sh…