First Star Ventures @FirstStarVC

take it a step further: what if drugs developed overseas had to be sold to US patients at the same prices they charge where they were developed?

Jason Kelly @jrkelly

5 days ago

"Here’s an idea: maybe we can measure the cost per drug sourced from China relative to the US, and perhaps drug prices in the US should be adjusted to reflect their country of origin. If there is an outcry from pharma and venture funds, then you will know that this movement is

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What does it take to build a health device people actually trust? Often, it starts with first-hand experience. Our co-founder & Chief Product Officer, @JohnCapodilupo, was one of the earliest founders and builders in wearables — he built @WHOOP into a household name. While building it, he was diagnosed with ulcerative colitis, and John has been quite open about sharing his journey ever since, so others can understand how he manages his health over time. He joined @bowelmomentspod for one of his most personal conversations yet. He talks through his IBD diagnosis, the realities of managing a chronic gut condition, and why the microbiome is still one of the biggest unsolved stories in health. John connects that narrative to what he's building now with @ThroneScience – a smart sensor that clips on to your toilet to make gut health something you can track passively, every day. Throne turns guesswork into longitudinal data that can reveal patterns a single snapshot never could. An honest, generous conversation about IBD, data, and building from lived experience. 🎧 Full episode in the comments

LastPass CTO Jason Rasmussen leads an engineering organization of roughly 200 people. Structured to allow engineers to take ideas from inception all the way to the customer, LastPass requires deep visibility into what it actually takes to ship software on time...and Jason needed to replace the "divining rod" with data. Now, LastPass leverages Jellyfish to: - manage unplanned work - benchmark their progress - measure the impact of their AI transformation - ship 40% faster Here's the story of how Jason and his team turned AI hype into hard data: jellyfish.co/case-studies/l… #CaseStudy #CustomerStory #AIROI

We have no ownership targets at @FirstStarVC . We have target multiples because DPI is what matters.

John Felix @johnfelix123

2 weeks ago

One of the dumber LP heuristics in VC: “we need to see 10%+ ownership from our GPs.” 10% of what? All else equal a $25m getting 5% is more attractive than a $75m fund getting 10%. And 3% of a great company is worth much more than 10% of a mediocre one.

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You sit. You poop. And receive the most detailed health report every day. Yet you turn away, flush, and miss out on what your body was trying to tell you. We created The Ultimate Guide to Poop to change that. Because getting curious about your poop is the first step to taking control of your gut health, your digestion, and what your body is signaling every single day. 🚽💩 #UltimateGuide #GetCurious #ThroneScience

🎊 Just released: Flo Health's Director of Engineering for AI Platform, Vladislav Nedosekin, joins ✨ GLOW and discusses how they built safe, useful AI for 500M+ Users, with learnings like: - Flo built an evaluation system with 50+ medical judges to assess AI-generated content — a concrete model for orgs where domain expertise must gate model outputs - Key leadership question raised: How do you define "safe enough" for AI output when the downstream impact is personal health decisions? - Flo runs hundreds of experiments per quarter — AI is used upstream to prioritize hypotheses before they reach users, compressing the product validation cycle Watch this 15-minute episode now: jellyfish.co/glow-2026-vide… #GLOW26 #AIFirst #AIEngineering

Nicholas Arcolano, head of research at Jellyfish, told TechCrunch via email that expenditure on AI is exploding in large part due to agentic features, with per-developer consumption rising about 18.6x in nine months. All in all, these stats make the productivity case murkier than the spending suggests. “Whether extreme spend pays off comes down to the ultimate business value of shipped code (e.g. revenue), which most companies still can’t measure,” Arcolano said. According to Arcolano, the smart move is broad, moderate adoption. “The best ROI comes from moving the broad middle from low to moderate usage, not pushing heavy users higher,” he said. Learn more: techcrunch.com/2026/06/05/the…

📈 Token consumption is on the rise...to no one's surprise. Jellyfish research recently published an AI Engineering Trends report showing just how drastic the jump has been year to date. In May, P90 is at 173M weekly tokens/user. How does your R&D org stack up? Dive into the data here: jellyfish.co/ai-engineering… #AIEngineeringTrends

🦓 Progress in the rare disease space is accelerating like never before! Catch the @iOrganBio team next week in Boston at the 2026 World Orphan Drug Congress as we connect with other innovators who are tackling some of the biggest challenges in medicine. COO @karol_jarzabek and BD Lead Lucas Abbott will be in Boston to share how iOB’s CellDiscovery™ Platform is enabling generation of personalized drug discovery models and powering n-of-one clinical trials for rare diseases, and the CellForge™ Platform is enabling scale-out and scale-up of precision cell manufacturing. Together with our partners, we’re helping to transform the approach to rare diseases, unlocking new approaches to personalized therapy development and bringing hope to patients and their loved ones with The Right Cells, Consistently, At Scale. 📝 Register for WODC 2026 at terrapinn.com/conference/wor… 🌐 Learn more about iOB’s technology at iorgan.bio ✉️ Explore partnering opportunities by emailing [email protected] #RareDisease #OrphanDrugs #WODC #PersonalizedMedicine #Nof1 @orphan_drugs @OrphanConf

The idea of scaling autonomy is simple on paper: build more trucks to haul more freight. But the reality is being strategic about what an autonomous network looks like, and understanding that autonomy removes one of the biggest questions in network design: does the labor exist to make a location in my network make sense? That's what Brett Suma is here to answer. freightwaves.com/news/bot-auto-…

It's finally here! ✨ The GLOW 2026 video series features Leading Voices at the Intersection of AI and Engineering from @LoadsmartUS, @Q2_Software, @incident_io, @googlecloud, @awscloud, @Avaya, @blitzyai, @OpenHandsDev, and more...and these under-20-minute episodes are now available for you to watch anytime, anywhere. Software was eating the world. Now AI is eating software. But you're not alone. Watch the first 4 episodes and learn how AI is changing how teams build, measure and deliver impact in modern engineering organizations: jellyfish.co/glow #GLOW26 #AIFirst #AIIsEatingSoftware

Welcome Dr Pang!

iOrganBio @iOrganBio

4 weeks ago

iOrganBio is excited to share the addition of Zhiping Pang to our Scientific Advisory Board. As one of the world’s foremost experts in human neuron biology, synaptic function, and the molecular mechanisms underlying neuropsychiatric and metabolic disorders, Dr. Pang has

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Excited to rep Boston and be one of the funds participating.

andrew chen @andrewchen

a month ago

the team built a way for founders and investors to get intro'd at Tech Week! Use it May 26 (today) to Jun 7 to meet connect try it here: intro.tech-week.com how it works: - Founders sign up and say what they're building - VCs hit the same link for investor access, then

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Jellyfish SVP of Engineering Adam Ferrari reflects on findings from the 2026 State of Engineering Management report. In this short, he shares his reactions to AI costs and tool proliferation challenges. Watch the full video here: jellyfish.co/events-and-web… And explore the report here: jellyfish.co/2026-state-of-… #SEMR26 #StateOfEngineeringManagementReport #AICosts

Long before modern medicine, people were deeply curious about what their body released. Western medicine made that taboo. That curiosity is worth reclaiming.

partiful.com/e/MyfKGX0Dl8Bi…

Reminder, we're doing a fireside chat next week (Thu 5/28) in Cambridge with some awesome founders who are: - making human cells and tissue - monitoring gut health with smart toilet cameras - revolutionizing liquid biopsy Come hang out! (registration link next tweet)

Today is World IBD Day, and my co-founder @JohnCapodilupo wrote something I hope you will read. There are two things you need to know about John: 1/ Before joining @ThroneScience , John was co-founder and CTO of @WHOOP , where he pioneered wearables and popularized metrics now used by millions, like HRV and sleep scores. 2/ Ten years ago, he was diagnosed with pancolitis, the most severe form of ulcerative colitis. I've said it a thousand times, and I'll say it a thousand times more: there is no one who more perfectly understands the value and importance of what we are building than John Capodilupo. Throne sits at the exact intersection of his personal and professional life. As you read John's blog, you will find he is a gifted and empathetic writer. He brings that same empathy to every decision he makes that shapes Throne. Throne is not a medical device and it's not a substitute for traditional care. But for the millions of people living with IBD, and the many more who simply want to understand their gut, we believe the toilet is the most underutilized data surface in the home. It's the adventure of a lifetime to build Throne with John. Read his piece here, and if you can, support the @CrohnsColitisFn today. thronescience.com/blog/world-ibd…

Join us next Thursday, May 28th Heeding Nature's Call: Reading the Body with AI 👇

iOrganBio @iOrganBio

a month ago

✍️ Design 🏗️ Build 💥 Test 💡 Learn These are the core engineering principles that guide the iterative design of everything spanning ballpoint pens to fighter jets. And now we can do the same for cells—completely automated—made possible by advanced robotics and AI. As part of

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🌊 The next wave of AI transformation is here. Yet, most organizations still struggle to measure impact and prove ROI. Join Blitzy's CTO Sid Pardeshi and Jellyfish SVP of Engineering Adam Ferrari tomorrow as they break down what separates high-performing teams from the rest...and how your organization can learn from and apply those insights: jellyfish.co/events-and-web…