GeroScience @GeroScienceAGE

🎉 Congratulations to all winners and Honorable Mention recipients of the 2026 GeroScience Publication Awards! We are proud to recognize these outstanding contributions to the fields of aging biology, translational geroscience, neuroscience, metabolism, longevity, and clinical aging research. Your innovative work continues to advance our understanding of the biology of aging and age-related diseases. 👏 Congratulations to all awardees and thank you for choosing GeroScience as the home for your research. 📖 Read the award-winning and Honorable Mention articles here: link.springer.com/journal/11357/… #Geroscience #PublicationAwards #AgingResearch #Geroscience #HealthyAging #ScientificExcellence #LongevityResearch

🧬 New in GeroScience! In this systematic review and critical appraisal, João Antunes and Daniel Moreira-Gonçalves evaluate the longitudinal evidence on molecular predictors of incident frailty. The authors identify promising biomarkers associated with frailty development while highlighting important gaps and challenges in the field, emphasizing the need for robust, longitudinal studies to advance precision approaches to healthy aging. Read the article here: rdcu.be/fpvZA #GeroScience #Frailty #Biomarkers #HealthyAging #PrecisionMedicine #AgingResearch

🧴🌍 New in GeroScience! In this review, Diala Haykal and Frederic Flament propose a translational framework positioning the skin as both a sentinel and modulator of systemic aging. The authors explore how age-related changes in the skin reflect broader biological aging processes and discuss the potential of skin-targeted interventions as evidence-based gerotherapeutic strategies to promote healthy aging. Read the article here: rdcu.be/fpvTO #GeroScience #SkinAging #Gerotherapeutics #HealthyAging #TranslationalResearch #BiologicalAging #AgingResearch

🏃‍♀️🧠 New in GeroScience! In this randomized controlled trial, Simon J. Schrenk and colleagues examined the effects of an online-guided physical activity intervention on cognition, resting-state brain connectivity, and the gut microbiome in healthy older adults. Their findings highlight the potential of accessible, remotely delivered exercise programs to support brain health and healthy aging while providing new insights into the connections between physical activity, the brain, and the gut microbiome. Read the article here: rdcu.be/fpvRK #GeroScience #HealthyAging #PhysicalActivity #BrainHealth #GutMicrobiome #Cognition #DigitalHealth #AgingResearch

🥗🧠 New in GeroScience! In this population-based target trial emulation, Belayneh Mengist and Mohammadreza Mohebbi investigated the relationship between dietary inflammatory potential and mental health outcomes in older adults. Their findings suggest that adherence to an anti-inflammatory diet is associated with better mental health outcomes, supporting the role of dietary strategies in promoting psychological well-being and healthy aging. Read the article here: rdcu.be/fpnt8 #GeroScience #HealthyAging #MentalHealth #Nutrition #AntiInflammatoryDiet #AgingResearch

🏃‍♀️ New in GeroScience! In this study, Céline Ben Hassen and Archana Singh-Manoux evaluate a fitness assessment tool in early old age and its ability to predict long-term risk of disability, severe disability, and mortality. Their findings highlight the value of early fitness evaluation as a simple approach to identifying individuals at increased risk of adverse aging outcomes, supporting preventive strategies to promote healthy aging. Read the article here: rdcu.be/fpntv #GeroScience #HealthyAging #PhysicalFitness #DisabilityPrevention #Longevity #AgingResearch

📢New in GeroScience! In this longitudinal study, Eloïse Da Cunha and Auriane Gros explore the potential of speech as a dynamic biomarker of physical aging. The authors demonstrate that age-related changes in speech patterns may provide valuable insights into physical health and functional decline, supporting the use of speech analysis as a scalable, non-invasive tool for aging research. Read the article here: rdcu.be/fpnrm #GeroScience #HealthyAging #Biomarkers #SpeechAnalysis #DigitalHealth #AgingResearch

The medical community has an irrational aversion to rapamycin due to its organ transplant history. Side effects like mouth sores and glucose dysregulation are treatable and reversible. Is it a worthwhile trade for preventing dementia?

🧬 Registration for the Oklahoma Nathan Shock Center 2026 Geroscience Symposium is open now! For more information about the symposium, visit our website: oklahomanathanshockcenteronaging.org/geroscience-sy…

Senolytic treatment with dasatinib and quercetin selectively improves cardiac autonomic balance in obesity link.springer.com/article/10.100… @GeroScienceAGE

🦠 New in GeroScience! In this review, Christina M. Stevens & Kylie Kavanagh and colleagues examine how aging affects intestinal T cells and the consequences for gut barrier integrity and chronic inflammation. The authors highlight the critical role of age-related immune changes in the gut as drivers of systemic inflammation, offering new insights into mechanisms underlying inflammaging and age-related disease. Read the article here: rdcu.be/fpbwT #GeroScience #Inflammaging #GutHealth #Immunology #AgingResearch #HealthyAging #GutBarrier

Alzheimer's disease might be compensated by increased motivation. Rapamycin may restore neurotransmitter activity in the brainstem, boosting mood and motivation. This could be key to overcoming cognitive decline. #AlzheimersResearch #Neuroscience #Rapamycin

Did you know your brain can keep forming new connections well into your 80s and beyond? Neuroplasticity doesn't have an expiration date. Research shows that mentally stimulating activities actively support cognitive resilience as we age. #AgingScience #Geroscience #BrainHealth

1 in 4 Americans will be over 65 by 2060. Most chronic diseases that define late life share one common driver: the biology of aging itself. #AGE funds the researchers targeting that root cause. Not just the symptoms. #AgingResearch #Geroscience

Loss of sirtuin 3 disrupts cellular senescence signaling pathways link.springer.com/article/10.100… @GeroScienceAGE

Happy to share that another one of our articles has been accepted in @GeroScienceAGE, the official journal of the American Aging Association @americanaging A double reason to celebrate: the journal’s Impact Factor has just increased from 5.4 to 6.0 🚀 📌 Intrinsic capacity and mortality in community-dwelling octogenarians: a network analysis from the ilSIRENTE study In this study, we explored the role of intrinsic capacity in community-dwelling octogenarians using data from the ilSIRENTE cohort. Key points: • The study included 319 adults aged 80 years and older, with a mean age of 85.4 years. • Network analysis showed close relationships among vitality, psychological capacity, and cognition. • Sensory functions, including hearing and vision, appeared more peripheral, but were connected with locomotion. • Locomotion emerged as a central domain, linking sensory function, cognition, and survival. • Higher locomotion scores were independently associated with lower mortality at both 4 and 7 years. • Each 10-point increase in intrinsic capacity was associated with a lower risk of mortality. 🔗 pubmed.ncbi.nlm.nih.gov/42303956/ #GeroScience #HealthyAgeing #IntrinsicCapacity #Geriatrics #Longevity #AgingResearch #ClinicalResearch

🎉 We are excited to announce that GeroScience's Impact Factor has risen to 6.0! This achievement further strengthens GeroScience's position as a leading journal in the field of aging research and reflects the dedication, expertise, and hard work of our authors, reviewers, editors, and editorial board members. Thank you to our entire community for making this possible. We look forward to continuing to publish high-impact research that advances the science of aging and age-related diseases. #GeroScience #ImpactFactor #AgingResearch #ScientificPublishing @americanaging @ClinMedJournals

🧠 New in GeroScience! In this review, Hamad Yahia Abu Mhanna and Viktor Vegh examine the MRI brain age gap—the difference between chronological age and predicted brain age—across neurological and psychiatric disorders. Their work highlights the potential of brain age estimation as a biomarker of biological aging and disease-related brain health. Read the article here: rdcu.be/foJ9F #GeroScience #BrainAging #MRI #BiologicalAging #BrainHealth #Neuroscience #AgingResearch

🧠💪 New in GeroScience! In their latest study, Shoba Ekambaram & @zoltan_ungvari and colleagues demonstrate that cellular senescence in the brain can drive profound molecular changes in skeletal muscle, revealing a previously underappreciated brain–muscle axis in aging. Using transcriptomic analyses, the authors show that brain senescence induces gene expression patterns in skeletal muscle that resemble those observed in sarcopenia, providing new insights into how aging-related changes in the central nervous system may contribute to age-associated muscle decline. Read the article here: rdcu.be/foJ64 #GeroScience #Sarcopenia #CellularSenescence #BrainAging #MuscleAging #Transcriptomics #HealthyAging #AgingResearch

⚖️ New in GeroScience! In this longitudinal study, @RivasiGiulia & Andrea Ungar and colleagues examined the relationship between frailty, hypertension, and the risk of falls and syncope in older adults. Their findings highlight that frailty substantially increases vulnerability to adverse outcomes, emphasizing the importance of incorporating frailty assessment into the clinical management of hypertension in aging populations. A more personalized approach to blood pressure treatment may help reduce the risk of falls, syncope, and related complications in older adults. Read the article here: rdcu.be/foJ3M #GeroScience #Frailty #Hypertension #HealthyAging #FallsPrevention #Syncope #GeriatricMedicine #AgingResearch