Xuan Li_Lab @GroupXuan
Prof Xuan Li (BHF Senior Research Fellow) research group is based at the Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, UK xuanlab.org Cambridge, UK Joined September 2019-
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👀 We are recruiting for a Research Assistant to work on novel therapeutics to mend the broken heart❤️🩹with stem cells🧫, RNA 🧬Come join us in fun, collaborative, interdisciplinary environment! 🧑🏻🔬👩⚕️👩🏻🔬 @DrCathyWilson @UnivCamPharm @Cambridgecardio @SCICambridge @HLRI_Cambridge
Curious about the #Heart and #Cardiovascular #Research? 🫀 Dr Lay Ping Ong (@laypingong1) is recruiting for a Research Assistant! Our Research Associate roles in #Therapeutics research are also still open 👏 Click here to apply👉bit.ly/3OX6aR7
Only 3 weeks left to submit abstracts for our ECR symposium in Sheffield on 26th April! Head here for details and to submit your abstract: bscr.org/meetings/ecr24
Little News and Views @GroupXuan and I wrote. Still disappointed they didn't let us use the pun-tastic: You CANT(os) have CHIP(s) with JAK(ets) or your plaques may (fibro)Blast apart - but blocking IL-1b may help. doi.org/10.1038/s44161…
Our( with @MurrayClarkeLab ) News & Views (rdcu.be/dwftb) for @NatureCVR research article nature.com/articles/s4416…
Pleased to see our study is highlighted as the Editor's pick in JCI This Month. jci.org/articles/view/… jci.org/this-month/202… Thanks to @TheBHF
@antongistera @josejfuster @lassefolkersen @Hagberglab @antongistera thanks for all the organizers for your invitation. Broadly-covered research topics & great interactions & beautiful scene!
Karolinska Cardiovascular Research Retreat 2023. Thanks @josejfuster @GroupXuan @lassefolkersen @Hagberglab and all participants. 🫀
VSMCs are efficient activators of IL-1β that do not use canonical inflammasomes or caspases. Hence, this alternative pathway could be targeted for long-term treatment of CVDs, as it is not central to everyday host defence @MurrayClarkeLab @society_eas 🔗atherosclerosis-journal.com/article/S0021-…
N&V by @Prosser_Lab on the recent study by @C_M_Loescher, Johanna K. Freundt et al. pinpointing the contributors to #myocardial passive #stiffness. @PennMedicine|nature.com/articles/s4416… 👉rdcu.be/dqdpJ
Nature research paper: IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer go.nature.com/40oH0PI
PoV: your main PhD paper is finally published but the Uni's comms office decides that your cell biology and immunology research is best represented by a *big ugly foot* 👣 Still super proud, though. Great team effort @GroupXuan cam.ac.uk/research/news/…
This cover image for our research article jci.org/articles/view/… shows inflammatory macrophages with many NLRP3 signals (green) around the microtubule-organizing centre (microtubules in red). Taken by Yang Li & @chenxiao027 using Zeiss LSM980 with airyscan 2 @zeiss_micro
We show targeting microtubules via pharmacological drugs to inhibit PLK1 could provide a treatment strategy for inflammatory diseases characterized by excessive NLRP3 activation. cam.ac.uk/research/news/…
Cancer drug could hold hope for treating #inflammatoryDiseases including gout and heart diseases @Cambridge_Uni @jclinicalinvest doi.org/gs2842 medicalxpress.com/news/2023-11-c…
Check our paper published at JCI, featured as cover for this issue. Brilliant team members (@m_baldri Christain Doreth Yang Li @DrEmilyFW …) and collaborators (@zxh1121 @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat…) for this collective effort. Thanks to @TheBHF .
#Cover: PLK1 regulates NLRP3 inflammasome activation by controlling microtubule organization: buff.ly/3MmUEgj @GroupXuan @m_baldri @zxh1121 @DrEmilyFW @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat #CellBiology #Immunology
Labeling bio images just got 10x faster 🏎️ Watch our best AI model yet in action, released today as AI Detect on @BiodockAI. You prompt one object, it finds the rest. Try it for free now!
CAPture, a centrosome affinity purification method for mammalian cells, is finally out🥳 sciencedirect.com/science/articl… We found that a short peptide of CCDC61/VFL3 can be used to isolate centrosomes / basal bodies cell lysates
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