Gustafson Group @ Stony Brook @GustafsonLab

Asymmetric Synthesis and Chemical Biology gustafsongroup.sdsu.edu/wordpress/ San Diego, CA Joined June 2017

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Gustafson Group @ Stony Brook @GustafsonLab

2 months ago

The S-Atropisomer* had no KIT activity, but displayed intriguing selectivity towards LYN kinase, an emerging target for the treatment of cancer, autoimmune diseases and inflammatory conditions, that currently lacks highly selective inhibitors.

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Gustafson Group @ Stony Brook @GustafsonLab

2 months ago

The R-atropisomer* maintained potency against cellular models of GIST (IC50 < 10 nM) while displaying improved target selectivity, including towards key oncogenic c-KIT mutants. *Cahn-Ingold-Prelog priorities cause the analogs to have opposite stereochemical descriptors.*

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Gustafson Group @ Stony Brook @GustafsonLab

2 months ago

Another day another preprint on ChemRxiv! “Leveraging Atropisomerism to Obtain a Mutant-Selective c-KIT Inhibitor in Gastrointestinal Stromal Tumors” A story of privileged heterocycles, atropisomerism and kinase selectivity. chemrxiv.org/doi/full/10.26…

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Gustafson Group @ Stony Brook @GustafsonLab

2 months ago

This led us to introduce a peri Fluoro group as a H-bonding handle to ‘lock’ that axis into the trans conformation. This seemingly simple modification led to a dramatic increase in HER selectivity, particularly towards HER4, a kinase with emerging implications in ovarian cancer.

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Gustafson Group @ Stony Brook @GustafsonLab

2 months ago

The ‘conformational mapping’ of diarylamine crystal structures suggested that the pan-HER kinase inhibitor neratinib adopts two planar conformations around a C–N axes (similar to cis and trans alkenes). HER family kinases generally preferred the ‘trans’ conformation

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Gustafson Group @ Stony Brook @GustafsonLab

2 months ago

Excited to share our new ChemRxiv preprint: “Leveraging Conformational Control of Neratinib’s C–N Axes to Enhance HER4 Selectivity in Ovarian Cancer” congrats to the tam @StonyBrookChem and @SDSUChemBiochem Read here: doi.org/10.26434/chemr…

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Gustafson Group @ Stony Brook @GustafsonLab

4 months ago

The final version of this manuscript is up at @ACSCatalysis pubs.acs.org/doi/10.1021/ac…

Gustafson Group @ Stony Brook @GustafsonLab

a year ago

I am sharing this preprint from my group. Inspired by all the great recent skeletal editing work, we developed an atropisomer selective strategy to take Indoles to quinolines. chemrxiv.org/engage/chemr...

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Jeff Lipshultz @jeflip

4 months ago

Our department (@StonyBrookChem) is looking for a PRODiG+ fellow – the appointment is two years, followed by conversion to a tenure-track assistant professor at the conclusion of the fellowship. A unique opportunity! apply.interfolio.com/178732

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Gustafson Group @ Stony Brook @GustafsonLab

8 months ago

Reposting. One more week until the deadline!

Gustafson Group @ Stony Brook @GustafsonLab

9 months ago

The Stony Brook Chemistry Department is searching for a Chemical Biologist at the Associate or Full professor Level. Come join us on Long Island and do some great science! apply.interfolio.com/174211

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NaOH Bartfield, PhD 🧪 @NaOHBartfield

9 months ago

Doctor Gavin Rustin we salute you

Gustafson Group @ Stony Brook @GustafsonLab

9 months ago

Check out our latests work in collaboration with @Taylorlab_Chem ! We evaluated their biomolecular photocaged trifluormethylation reagent on small molecules, finding it effected the rapid trifluoromethylation of diverse aromatics, including several APIs. chemrxiv.org/engage/chemrxi…

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Gustafson Group @ Stony Brook @GustafsonLab

9 months ago

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Gustafson Group @ Stony Brook @GustafsonLab

9 months ago

The Stony Brook Chemistry Department is searching for a Chemical Biologist at the Associate or Full professor Level. Come join us on Long Island and do some great science! apply.interfolio.com/174211

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Organic Syntheses @OrgSynth

9 months ago

Professor Jeff Gustafson (Stony Brook University, @GustafsonLab) (gustafsongroup.sdsu.edu/wordpress/) presented the Organic Syntheses Lecture at Notre Dame on September 24th, 2025.

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Jeff Lipshultz @jeflip

9 months ago

Come join us at @StonyBrookChem! We are looking for an Assoc/Full Prof in Materials or Polymer Chemistry, supported by the SUNY Empire Innovation Program. Deadline Oct 16. Reach out if you have any questions! apply.interfolio.com/173681 #facultychemjobs

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Gustafson Group @ Stony Brook @GustafsonLab

a year ago

Just got back from another excellent Heterocyclic Compounds GRC and am excited to have been elected Vice-Chair. I look forward to putting together an exciting program in 2027! Happy to hear any cool ideas for session topics.

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Byron Purse @ByronPurse

a year ago

Call for Abstracts: An oral symposium on Synthetically Modified Nucleosides and Nucleic Acids on October 26, 2025 at the @CaliforniaACS Western Regional Meeting in San Jose! Apply, share widely, and DM or email me with questions. wrm2025.org/index.php/prog…

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Jeff Lipshultz @jeflip

a year ago

This week marked the Third SBU-BNL Photochemistry Supergroup, with a great poster session and 10 speakers from @StonyBrookChem and MSCE, @BrookhavenLab, @QC_News, @HofstraU, and @AdelphiU! Thanks to @SBUResearch for supporting this event!

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Gustafson Group @ Stony Brook @GustafsonLab

a year ago

here is the correct link: chemrxiv.org/engage/chemrxi…

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Gustafson Group @ Stony Brook @GustafsonLab

a year ago

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Gustafson Group @ Stony Brook @GustafsonLab

a year ago

This work was led by Ryan zanolini and Mariam Basilaia. It also involved a fun collaboration with @YuezhiMao that shed light on how stereochemistry was induced (spoiler alert: Dynamic Kinetic Resolution of the indole).