Ashley Laughney @LaughneyLab
Associate Professor @weillcornell @wcm_MeyerCancer Systems Biology of Metastasis laughneylab.com New York, NY Joined February 2018-
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Ashley Laughney retweeted
Early findings from a first-in-human trial of VLS-1488, an oral KIF18A inhibitor, show promising anti-tumor activity in heavily treated ovarian cancer. No dose-limiting toxicities were observed. Presented by Dr. Ecaterina Dumbrava at #ASCO25. #EndCancer
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Ashley Laughney retweeted
(1/2) A very exciting milestone for @VolastraTx and the field of #Chromosomal_Instability. Early escalation data for our KIF18A inhibitor, VLS-1488, show excellent safety and promising efficacy in heavily pre-treated ovarian cancer patients. businesswire.com/news/home/2025…
Ashley Laughney retweeted
Join us for the next @WCMEnglanderIPM #PrecisionMedicine Journal Club where Tri-I Computational Biology and Medicine (@cbm_student) graduate student Austin A. Varela (@AustinAVarela) will present a @Nature paper from Sept. 2024!
Ashley Laughney retweeted
Another elegant study by @eileen_parkes group showing how chronic #cGAS #STING activation from #Chromosomal_instability shapes the tumor microenvironment of esophageal #cancer biorxiv.org/content/10.110…
@NeilVasan @nyulangone @Perlmutter_CC Love this! Congrats Neil!!
Ashley Laughney retweeted
We hope to see you Thursday for the next @WCMEnglanderIPM #PrecisionMedicine Journal Club presented by @cbm_student @EthanEarlie on Thursday, April 24th from 3-4 pm in Belfer #1401 and via Zoom (DM for details)!
The next @WCMEnglanderIPM #PrecisionMedicine Journal Club will review the @Nature article "MHC Hammer Reveals Genetic and Non-genetic HLA Disruption in Cancer Evolution," presented by @cbm_student @EthanEarlie April 24th from 3-4 pm in Belfer #1401 and via Zoom (DM for details)!
@elhamazizi Congrats Elham!! So proud of you!!
@KarunaMDPhD @Nature @andrewrmoorman @elliebenitez11 @f_cambuli @KarunaGaneshLab @Dana_Per Big congratulations @KarunaMDPhD and @dana_peer!
Ashley Laughney retweeted
Our new study published today @Nature uncovers that Transgelin 2 preserves T cell lipid metabolism and anti-tumor activity. Transgelin 2 is silenced in dysfunctional TILs, and restoring its expression enhances CAR-T cell therapy in #OvarianCancer 👇nature.com/articles/s4158…
Ashley Laughney retweeted
Congratulations to Dr. Victor R. Ambros, former member of the @dartmouth Dept. of Biological Sciences and Geisel Dept. of Genetics, for being awarded the 2024 #NobelPrize in Physiology or Medicine, for the discovery of microRNA. home.dartmouth.edu/news/2024/10/f…
Ashley Laughney retweeted
Tumor Heterogeneity and Evolution: Nicholas Navin, Christina Curtis, and Ashley Laughney will address this topic in an educational session at #SABCS24 (December 10-13). Learn more: bit.ly/4eNLvcq @nicholas_navin @cncurtis @LaughneyLab
Ashley Laughney retweeted
Together with @CharlesSwanton, delighted to share that our new tool, MHC Hammer - which can detect different types of HLA disruption - mutation, loss, RNA repression and alt. splicing - is now out in #NatureGenetics and available to use…nature.com/articles/s4158…... 🧵below
Ashley Laughney retweeted
1/n 🚨 🧬Our paper on the role of #mitochondria and free radicals in promoting the collapse of #Cancer #micronuclei is out in @ScienceMagazine today. A story led by the brilliant @melodyDiBona it started with a simple question: why do micronuclei rupture? science.org/doi/10.1126/sc…
See also the amazing companion paper by the @SteSantaguida lab! Both shed important new light on this phenomenon. What a day for the field of #chromosomal #instability #CIN
Micronuclear collapse triggers chronic STING signaling that drives metastasis. But how do they rupture?? Beautiful work from the @Samuel_Bakhoum lab, led by brilliant physicist turned hard core cell biologist @melodyDiBona, explains how..
Micronuclei are frequently observed in tumor cells as a result of aberrant chromosomal separation. Two new Science studies investigate the cellular processes involved in micronuclear collapse. Learn more in this week's issue: scim.ag/8bF
Ashley Laughney retweeted
Very happy to have DNA O-MAP out! The DNA version of this work, started from a simple premise: how can we measure the proteome at any genomic loci in (nearly) any cell? This was a great collaboration with @oligopain, and led by Yuzhen Liu and @CD_McGann. 1/8🧵
Micronuclei are frequently observed in tumor cells as a result of aberrant chromosomal separation. Two new Science studies investigate the cellular processes involved in micronuclear collapse. Learn more in this week's issue: scim.ag/8bF
Ashley Laughney retweeted
Our new study, published today @CD_AACR, reveals that iron chelation therapy unleashes innate immune responses that control #OvarianCancer. Congrats to first author @titosandoval84 and the whole team. #Immunotherapy @WeillCornell @WCM_OBGYN 👇doi.org/10.1158/2159-8…
Ashley Laughney retweeted
Our second of a pair of reviews on how #Chromosomal_instability #CIN drives #cancer progression is out in @NatureRevGenet Reviews led by the talented @chenxuelan621 @itsalyourpal @JunLi_916 @melodyDiBona nature.com/articles/s4157…
Ashley Laughney retweeted
Our first of a pair of reviews on #Chromosomal_Instability is out in @NatRevClinOncol on targeting CIN in patients with #cancer written with the amazing @RawiDuaa @EmanueleLettera @JunLi_916 @melodyDiBona nature.com/articles/s4157…
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David Suter @davidsuter_epfl
2K Followers 300 Following PI at EPFL. Don't follow me ! Leave the X sh&thole. Keep your X account to avoid ID theft, and Join BlueSky ! @davidsuter.bsky.social
𝐍𝐨𝐨𝐫𝐳�... @DrNoorzaileen
168 Followers 645 Following PhD Scientist | Immune Microenvironment | Spatial/Single-Cell Omics | Bioinformatics & AI
Jake Qiu @qiutip1
134 Followers 631 Following somatic evolution and ecology | tech dev | phd-ing @WeillCornell and @nygenome| ex-@BroadInstitute | bioengineer alumni @Purdue | he/him
NAIT MOHAMED Faez A.,... @faeznm
529 Followers 1K Following Postdoctoral Research Fellow in @lingwoodlab at @ragoninstitute of MGH, MIT and Harvard. Immunology, flu, B-cells, espresso drinker. Milanista 🇩🇿 & 🇮🇹Trends for United States
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