Xiuning Le MD PhD @LeXiuning
Associate Professor Thoracic Head and Neck Medical Oncology MD Anderson Cancer Center faculty.mdanderson.org/profiles/xiuni… Houston, TX Joined March 2020-
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📖 🔥New online from our group at @UTMDAnderson on ultra-precision oncology in #lungcancer 👉 Analysis from over 22,000 #EGFR-mutant tumor samples identified #PACC mutations in 12% of cases (A) 👉 While classical and #Ex20 mutations more commonly occur as single mutations, PACC mutations are more frequently (66%) observed as compound mutations (B). 👉 PACC/PACC and PACC/classical-like compound mutations function biologically similar to single PACC mutations, NOT classical mutations (C) 👉 Compound PACC mutations demonstrate greater sensitivity to EGFR TKIs than single PACC mutations (D) ⚡ 💡 Largest #EGFR mutation landscape in a Western population. ⚡ 💡 #Compound EGFR PACC Eare biologically analogous to #single PACC. ⚡ 💡 Important insights for drug development of next-generation EGFR TKIs.
🎀 💗Strong team work! BH-30643 represents a next-generation #EGFR #TKI that is potentially 10x more potent than osimertinib, strong CNS penetrance, and able to overcome on-target EGFR resistance! @Exon20Group @EGFRResisters @UTMDAnderson @mollylisc @geoff_oxnard @jjeancui
🆙 #ASCO26 #LCSM Rapid Oral 🔥SOLARA: BH-30643 (Macrocyclic OMNI-EGFR TKI) in EGFRm ✅C797S+ ORR 59% ✅C797S VAF >99%📉in 7/9 ctDNA+ pts ✅G3 AEs 18% (mainly T-bil) 🎙️ @LeXiuning @HHorinouchi 🔢3014 ☑️NCT06706076 🔗 asco.org/abstracts-pres… @OncoAlert @Larvol @ASCO @IASLC
Kicking off #ASCO26 by celebrating the Giants of Cancer Care induction ceremony! 🎀Congratulations to Dr. Wakelee @HwakeleeMD for Thoracic Malignancy 🎀Congratulations to Dr. Kopetz @skopetz for GI Maligancy @UTMDAnderson 🎀Congratulations to Dr. William Wierda for Leukemia 💐💐💐With friends @drgandara @JoelNealMD @riess_md
At #ASCO26, the @UTMDAnderson Thoracic Medical Oncology Department will deliver an incredible 9 oral presentations💐💐💐 highlighting advances across ##EGFR, #HER2, #KRAS, #KEAP1/STK11, #SCLC, IO, #peri-operative, all lung cancer subgroups. For perspective, thoracic medical oncologists from China have 16 oral presentations. 👩⚕️🧑⚕️ 👩🔬🧑🔬Our entire MDA Thoracic team @FSkoulidis @NIVokes @LaurenByersMD @lungoncdoc Drs. Heymach, Cascone, Zhang, @mvnegrao @YYElamin @AnneTsao2 are deeply proud and excited 😀to help shape the future of lung cancer research and patient care alongside outstanding collaborators and industry partners.
Dr. Stephen Liu @StephenVLiu gave the insightful vision on how #AI will impact our clinic, including patient care, physician wellness, clinical research and drug development. @StephenVLiu at #RomeLung26 Thank you @FedericoCappuz1 @BRicciutiMD for organizing this fantastic #lung #summit
Exciting program with impressive global faculty at #RomeLung26 with chairs @FedericoCappuz1 and @BRicciutiMD starting the meeting!
Strongly support my @UTMDAnderson colleague Dr. Hussein Tawbi @HTawbi_MD for #SITC Director election ❤️💐 👉Hussein is an internally renowned #physicianscientist immune-oncology leader who has helped redefine what immunotherapy can achieve in some of the most challenging clinical settings. 👉His leadership of the CheckMate 204 study established the role of nivolumab + ipilimumab in melanoma brain metastases, a historically underserved population, 👉He led RELATIVITY-047 which enabled the approval of nivolumab + relatlimab, introducing LAG-3 as a new checkpoint target. His voice and compassion, grounded in patient care and scientific rigor, would be an outstanding addition to the #SITC Board as we navigate the next era of immunotherapy innovation. 🚀
The #SITC election starts on Friday! The three At-Large Directors who receive the plurality of votes will begin three-year terms in 2027. Read the biographies and platform statements of this year’s candidates at sitcancer.org/get-involved/2…
Strongly support Dr. Zhen Su @MyOncology , my friend, colleague, and mentor for SITC Director election. 💪❤️ 👉When he served as the global oncology leader at #MerckKGaA/#EMDSerono, he translated complex immune biology to approvals, then becaome impactful therapies for patients. He has multiple global approvals across agents such as #avelumab, #tepotinib, #erbitux and others. 👉Now as the CEO of #Marengo, he is a true architect with vision, taking first-in-class T-cell agonist programs from platform stage into human studies and secured strong partnerships. 👉Zhen has been a long-standing contributor to the #immuno-oncology community, including leadership roles within #SITC. His vision of bringing early discovery to global commercialization will continue shaping the development of next generation immunotherapies. 🚀
The #SITC election starts on Friday! The three At-Large Directors who receive the plurality of votes will begin three-year terms in 2027. Read the biographies and platform statements of this year’s candidates at sitcancer.org/get-involved/2…
Appreciate @StephenVLiu and @CharuAggarwalMD organizing a fantastic US Focus Meeting Lung Cancer. I discussed 1L EGFR-mut NSCLC landscape evolution with friends and colleagues @riess_md @JuliaRotow @JustinGainor @ShirishGadgeel @BalazsHalmosMD. Nashville is a charming city with such fun characters.
Inaugural US Focus Meeting on Lung Cancer from @_MDEducation starts in Nashville with EGFR session. Great overviews by Drs. @LeXiuning Liza Villaruz @ZPiotrowskaMDand panel chaired by @CharuAggarwalMD. Great areas for discussion including LCT, bispecifics, and ADCs.
@StephenVLiu But super productive?!
😊 🩷 Nice to see friends and colleagues in the #lungcancer community from different continents at #ELCC26. @caliraf @Alfdoc2 @HHorinouchi @MartinReck2 @Tony_Calles @DoctorJSpicer @fred_hirsch @bensolomon1 @NReguart @BalazsHalmosMD @BrendonStilesMD @mollylisc @karenkellymd @ThomasW35874311 @NadalErnest @DrSanjayPopat 😊 🩷 Safe travels ✈️ 💐💐💐Grateful for the wonderful organization between @IASLC and @esmo for an impactful and fun #ELCC26.
We discussed innovations in ADCs to overcome topo-payload ADC resistance. 🔥Novel payloads include dual-cytotoxic, radioligands, immune stimulators or engagers, oligonucleotides (siRNA), degraders, and small molecule inhibitors. 🤣 Yes, "Any-Drug-Conjugates (ADC)" ❤️💡
💥 Beyond traditional ADCs at #ELCC26! @LeXiuning ▪️Masked ADCs → tumor-activated targeting ▪️Nanobodies & peptides: better penetration, new epitopes ▪️Bicycle toxin conjugates: ultra-small, fast delivery 🎯 Innovation across 3 axes: target, linker, payload From ADCs to
Honored to be delivering two educational lectures at 🔜 #ELCC26 @myESMO🇩🇰 in Copenhagen. 📍 March 26. 👉Beyond traditional ADCs: Advances in targeting, conjugation, payload design, and emerging modalities 📍 March 28 👉Mechanisms of resistance: Lessons from EGFR-mutant and ALK-rearranged NSCLC 💐Grateful to the conference chairs @DrSanjayPopat @APassaroMD for your excellent work on organizing #ELCC26. 💗Looking forward to great discussions and connecting with global colleagues @HHorinouchi @ThomasW35874311 @Alfdoc2 @caliraf @tnewsomdavis @YYElamin @lungoncdoc
Please (re)watch the powerful Special Speech delivered by Dr. Ross Camidge @DRCamidge at #TTLC26 @IASLC An internationally renowned thoracic oncologist, Dr. Camidge shared something profoundly personal: his own diagnosis and treatment journey with stage IV #EGFR-mutant #NSCLC. His reflections were thoughtful and deeply human. It is a reminder that before we are physicians or patients, we are human beings: vulnerable yet resilient. Please: ❤️ Act with urgency. ❤️ Treat with respect and gentleness. ❤️ Move forward with courage and hope. @ShirishGadgeel @lungoncdoc @KarenReckampMD @TejasPatilMD
At #TTLC26, @DRCamidge shared powerful insights shaped by both clinical expertise and personal experience living with #lungcancer. His presentation reminds us why continued innovation in #lungcancer research is essential to improving patient outcomes every day.
❤️ ❤️ So happy and proud to wrap up a successful #TTLC26 @IASLC 💐🎊 👉 This year, we set new records: 🥇 🔥 the highest attendance, 🥇 🔥 the greatest number of submitted abstracts, and 🥇 🔥 unprecedented sponsorship support. 👉 This year, we hosted two extraordinary keynote speakers: my mentor Dr. John Heymach @MDAndersonNews and his mentor Dr. Bruce E. Johnson. Seeing multiple generations of thoracic oncology leadership on one stage was a powerful reminder that progress in our field is built on mentorship, collaboration, and legacy. Let it continue. ❤️ ❤️ Special appreciation to my dear co-chairs @ShirishGadgeel @KarenReckampMD and Dr. Paul Bunn, and outstanding @IASLC staff, especially Kelly Heemsbergen, for being consistently knowledgeable, responsive, and supportive behind the scenes. 👉 See you all again at hashtag #TTLC27
#TTLC26 @IASLC @YYElamin @MDAndersonnews Dr. Yasir Elamin discussed the landscape for 1L #EGFR mutant #lungcancer until now, and offered insights to the near future. 👉Intensification works for PFS and OS 👉More intensification strategies are coming.
Vivek Subbiah, MD @VivekSubbiah
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Stephen V Liu, MD @StephenVLiu
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Ivy Elkins @ivybelkins
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Lecia Sequist, MD, MP... @LeciaSequist
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IASLC @IASLC
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Aakash Desai, MD, MPH... @ADesaiMD
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Dana-Farber's EGFR Mu... @DFEGFRcenter
683 Followers 264 Following The Chen-Huang Center at @DanaFarber promotes #clinicaltrials, cutting-edge care, & education to strengthen treatment for patients with #EGFR mutant #lungcancer
Shannon Walch (Riley) @shannonriley_
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Naoki Furuya, MD, PhD @NaokiFuruyaMD
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Gloria Villatoro @glorex707
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Hogan Liang @HoganLiangHM
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Sahitya Rao @SahityaRao2
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Chiar Khalil @shiyar_shiyar
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Dr Sabiha Salsabil @salsabil0266
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Megan Cuff @MSC2344
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Vivek Subbiah, MD @VivekSubbiah
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Stephen V Liu, MD @StephenVLiu
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Narjust Florez, MD, F... @NarjustFlorezMD
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Christine Lovly, MD, ... @christine_lovly
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Jarushka Naidoo @DrJNaidoo
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Toni Choueiri, MD @DrChoueiri
45K Followers 346 Following Chief GU Cancers @DanaFarber II Prof Medicine @HarvardMed II ⚽ lover II @PanMass 🚲rider.
Ivy Elkins @ivybelkins
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Amirali Karimi, MD @Amirali_karimii
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Urs Weber MD @UrsWeberMD
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Edgardo Santos, MD, F... @EddieSantosMD
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Sarah Waliany, MD, MS @SWaliany
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Tom Powles @tompowles1
14K Followers 86 Following Interested in Urology Cancers, biomarkers and drug development.
Tony Zhuang @tonygazibo
399 Followers 497 Following Heme/Onc Fellow @MDAndersonNews via @EmoryMedicine, @UTHSCMedicine & @RiceUniversity. Nature enthusiast & lifelong learner
Paul Stockhammer @StockhammerPaul
505 Followers 443 Following Heme-Onc Fellow at @YaleCancer. Interested in #HER2 and #EGFR driven lung cancer. #LCSM
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GLCC @globalungcancer
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Annals of Oncology @Annals_Oncology
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672 Followers 445 Following Professor of Radiology at MD Anderson Cancer Center. Thoracic radiologist. Tweets are my own.
Nirmal Raut @oncologician
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Byoung Chul Cho, M.D.... @cbcbc1971
95 Followers 3 Following Professor, Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine
Giuseppe Banna @gbanna74
2K Followers 1K Following Consultant Medical Oncologist for Lung and Urology Cancer aiming to Clinician Scientist #lungcancer #urologycancer. I love my work but my family is my life
CA: A Cancer Journal ... @CACancerJournal
11K Followers 2K Following As the flagship journal of the American Cancer Society, CA publishes the latest cancer statistics, ACS guidelines, and reviews on the current state of cancer.
Raffaele Califano @caliraf
1K Followers 488 Following Thoracic Oncologist @TheChristieNHS, Honorary Professor @UoM_DCS . Member @myesmo Educational Publication WG. Views are my own No DMs or medical advice given.
TerriConneran @TerriConneran
1K Followers 882 Following T like Trouble @KRASKickers Too spunky for #LungCancer Kicking cancer’s #KRAS #research #advocate #survivor #hope ❤️🤣🙏#biomarker NO #KRASholes
Baby K💕 @vinaykjain17
162 Followers 273 Following Dm for meets|Facetime|custom vids available|HMU for enquiries| must be deposit ready⬇️|MDNI 🔞
DAVA Oncology @DAVAOnc
2K Followers 2K Following DAVA Oncology is a strategic consulting company committed to delivering high quality oncology education and expanding access novel cancer therapies.
ONCO BRUNO @brunolarvol
7K Followers 7K Following @LARVOL | 100 experts building onco super intelligence | 200,000 KM curves digitized | free for non-commercial use | ex-IBM
Federica Pecci @pecci_federica1
476 Followers 544 Following Research Fellow at @DanaFarber Thoracic Oncology
jamei_zhang @jaemi_zhang
2K Followers 329 Following Chinese entrepreneur living in the US. I run my own business and enjoy traveling and fishing. Let’s connect and share good vibes together.
Misty Dawn Shields @drshieldsmd
2K Followers 2K Following Translational Thoracic Oncologist #MDPhD, #SCLC, @TheShieldsLab, Indiana University, HHMI Med Into Grad Scholar/IASLC ILCF/ASCO CDA, founder @SCLCSMASHERS 🫁🤍
OncoAlert @OncoAlert
42K Followers 137 Following 🌐 Worldwide oncology professionals network | Run by oncologists, for colleagues | All tumor types | Non-profit 🚨 We are #OncoAlert | Oncology360°
Susan Combs Scott, MD @SusanScottMD
962 Followers 491 Following Thoracic Medical Oncologist at Johns Hopkins at Sibley @hopkinskimmel @sibleyonline
Biagio Ricciuti, MD, ... @BRicciutiMD
640 Followers 35 Following Thoracic Medical Oncologist at @DanaFarber | @harvardmed #Immunotherapy #KRAS #BRAF #MET #LungCancer
Raffaele Colombo @raffcolo
3K Followers 919 Following ADCs, targeted therapies, chemistry, biotech, pharma. Director @ Zymeworks
Ana I. Velázquez Ma�... @AnaVManana
7K Followers 5K Following Medical oncologist & researcher focused on #LungCancer 🫁 @UCSFCancer @ZSFGCare | Assistant Prof. @UCSF | Views are my own. Boricua 🇵🇷 aunque naciera en la 🌙
Dr. Antonio Calles �... @Tony_Calles
12K Followers 4K Following Medical Oncology 🏥 Hospital General Universitario Gregorio Marañón ⎪@myESMO Faculty 🫁 ⎪#endlungcancer #lcsmYou might like
