Mohana Maddula @MPMaddula
Stroke & Eldercare Physician. Views are my own Carnon Downs, England Joined March 2021-
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TNK effective up to 24h in non LVO AIS with salvageable brain. We knew this was coming! jamanetwork.com/journals/jama/…
-short report turnaround time and closed-loop communication is necessary for relevance in hyperacute management of stroke -delayed adoption of new technology that facilitates an emerging standard of care may create medicolegal exposure
@ShadiYaghi2 But it may not all be about neglect. Sounds like he was pretty certain about onset time and I would’ve thought benefit of doubt ought to have gone with the patient, especially with a plumb normal NCCT
In a systematic review and study-level meta-analysis, TNK improved excellent functional outcomes and recanalization in AIS patients treated within 4.5-24 hours, without increasing the risks of sICH or mortality. #stroke ahajrnls.org/4nMEfSn
@PracticalNeuro @JAMANeuro @EVToday @American_Stroke @AANmember Good to bear in mind though that study participants were a mixed bag with: carotid or intracranial artery stenosis, noncardioembolic stroke, ischemic heart disease, or peripheral artery disease.
🧠You can still register for the #WSC2025 Highlights Webinar — hosted by ESO, @WorldStrokeOrg and @American_Stroke. Get key updates in stroke research & care. 🔗us02web.zoom.us/webinar/regist… #Stroke #StrokeScience #StrokeEducation #Neurology @SposatoL @eva_mistry @jeyaraj_pandian
🧠Join us online on 6 Nov 2025 for a #WSC2025 Highlights Webinar — hosted by ESO, @WorldStrokeOrg and @American_Stroke. Get key updates in stroke research & care. 🔗us02web.zoom.us/webinar/regist… #Stroke #StrokeScience #StrokeEducation #Neurology @SposatoL @eva_mistry @jeyaraj_pandian
Would help in identification of underlying stroke mechanism and targeted secondary prevention
Congratulations @ShadiYaghi2 on the new classification system. Specifying the minimum diagnostic work up is an important advance, and one that’ll have important resource implications for Stroke services @BIASPstroke @HargrovesDavid
The stroke field had major developments since 1993 when the TOAST criteria were proposed. We need move on to a different system that incorporates new mechanisms/tools/testing and standardizes the minimum workup. Introducing ISPS25 #stroke #WSC25 #meded ahajournals.org/doi/10.1161/ST…
TNK improves excellent outcomes & recanalization in pts w/ acute stroke treated w/i 4.5-24h, w/o increasing symptomatic ICH or mortality, and provides greater additional benefits when EVT is inaccessible.🧠 shorturl.at/8IpSD #SCCMNeuro #NeuroICU #NeuroTwitter #NeuroX
#STROKE: This special report by @AmolMehtaMD et al. critically appraises recent literature on endovascular thrombectomy for medium vessel occlusion stroke and offers consideration for practice. #AHAJournals ahajrnls.org/46pRdi0
Just when we thought TNK it is … In patients with salvageable brain tissue identified by perfusion imaging who did not initially receive MT, alteplase given 4.5 to 24 hours after acute ischemic stroke onset improves outcomes jamanetwork.com/journals/jama/…
#MondayTip #BloodPressure management in Acute Ischemic Stroke ☝️Stability > aggressiveness 🚑Pre-reperfusion: #tolerate high BP (<185/110 if IVT, <220/120 if no reperfusion). 💉Post-reperfusion: #avoid intensive lowering, safer range is ~140–180 mmHg 🆓doi.org/10.1007/s11910…
This is just what we need! @RCHTWeCare @Redsnapperswail Looking forward to EoI for TASC cohort 3 from @NHSElect
nhselect.nhs.uk/uploads/files/… Delighted the Thrombolysis in Acute Stroke Collaboration (TASC) tool kit is now available ☝️ 18 hospitals with low IV lysis rates @NHSEngland demonstrated phenomenal agency, learning & improvement, averaging: 45% ⬆️rates & 20mins ⬇️DTN 👏 @NHSElect
Please RT and please help! @audreybowenprof @preston_jenny @CharlieChung90 @KaterinaHilari @NikolaSprigg @TheStrokeAssoc
Are you a UK-based clinician working with people who've had a TIA or minor stroke in the past year? Help us improve psychological care by taking part in the @OPTIMISE_study online survey. It only takes a few minutes! forms.office.com/e/RWuWQgbwYW @DrEiriniKontou @ARC_EM @InstituteMH
The 2024 Lancet Commission stated that there are multiple preventable risk factors for #dementia. Addressing these factors may reduce future risk but there is a lack of interventional studies.
#MondayTip #DWI_negative AIS 📊Meta-analysis, 3,236pt➡️6.8% had clinical diagnosis of AIS w/DWI (-) 🔑Post. circulation is key: 5x greater odds of (-) DWI vs anterior strokes ⏰Timing & size matter ☝️While DWI is highly sensitive, it can still be falsely (-) in selected AIS cases
Great to see Radiology & Stroke clinicians come together to learn about CTP. We need this for #strokecare Thanks to all speakers and a special shout out to @rayessastroke for coming down all the way from Hull! @HargrovesDavid
An underrated life lesson: Your energy creates your reality. Give your energy to stress, complaints, and negative people, they will grow. Give your energy to ambitions, gratitude, and positive people, they will grow. Your energy is your destiny. Choose wisely.
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