Mandl Lab @MandlLab
Immune cell dynamics, migration, and diversity in cells & people @mcgillu. Account run by an exceptional team of trainee-clowns 🧑🔬🤡, with critical PI input. jmandl.lab.mcgill.ca Montréal, Québec Joined June 2022-
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Following261
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Huge congratulations to Dr. Connie Shen @peepingcells on delivering an outstanding thesis defense! Our fourth Mandl PhD will soon be leaving the nest, trading cold Montréal for sunny California! ☀️All the best!
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Mandl Lab retweeted
NEW POST ALERT just in time for the start of school! Let's talk about T-cell education. Although the curriculum these immune soldiers undergo has only 2 main topics the process involving this education is intricate and extremely beautiful #ImmunologyForAll immunothoughts.com/how-our-immune…
Congrats on your travel award to #CSI2024 Sam!! 👇
Mandl Lab retweeted
Congratulations to all #CSI2024 travel award winners! ✈️
Want more details? Dive into the full study here: doi.org/10.1371/journa… 🔗
Interestingly, against a chronic fungal infection 🍄that T cells can't clear, both our model and experiments agreed that this TCR diversity didn't offer any extra protection. So, it seems that these low-binding TCRs are useful for certain chronic battles!
Check out our recent publication in collaboration with the Khadra Lab at @mcgillu - where computational modelling 🖥️ and experimental immunology 🔬join forces to study the role of T cell diversity and antigen binding strength on chronic infection clearance! Find out more 👇
>90% of #TCR sequence diversity is generated by TdT-mediated nucleotide addition, but what is the benefit of TdT-altered TCRs? @MandlLab show that low-affinity #Tcells generated by TdT are important for curtailing chronic pathogen replication #PLOSBiology plos.io/3HJKOCl
Mandl Lab retweeted
First MIM happy hour of the year is tomorrow! Who else is coming? 😎 Le premier 5 à 7 de l'année de MIM est demain! Qui d'autre prévoit y être? 👀
Bonne année à tous! // Happy New year to all! Reminder! The next MIM happy hour will be from 5 to 7 PM on January 23, 2024 @ Pub l'Île Noire 🍻🍕 Rappel! Le prochain 5 à 7 de MIM sera le 23 janvier 2024 au Pub l'Île Noire See image for details // voir l'image pour détails
Mandl Lab retweeted
Excited to share a new preprint from our group! Marie-Ève and team demonstrate an unexpected role for NGFR/CD271 in directly suppressing T cell activity! biorxiv.org/content/10.110…
Our PhD student Angela @ImmuneVet co-host of the TWiV podcast with @profvrr recently interviewed @bjesseshapiro and Corinne Maurice with their students Sana Naderi and Anshul Sinha about their cool virus research going on at @mcgillu! @McGillMed 📺bit.ly/3Hb9Aet
Mandl Lab retweeted
Please distribute 2024 flyer!
And this work featured on the current issue cover! Amazing collaboration with @JohannesTextor @MelicharLab, and the Westermann team
Wondering what we can learn from the T cell receptor beta sequence about the self-reactivity of a T cell? check out our paper in Cell Systems where we used machine learning to ask this very question👇: cell.com/cell-systems/f…
Mandl Lab retweeted
First talk of the evening is by Dr. Mandl who will talk about T cell migration 🧫 La première présentation est par Dre Mandl qui va nous parler de migration cellulaire 🔬
Exciting! 👇
Looking forward to resume our Global Immunotalks on Wednesday, August 2nd with Dr. Lora Hooper's seminar entitled "Regulation of gut immunity by the microbiome and vitamin A". Check out our new 2023 poster and please spread the word ! We hope you tune in !
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