Matthew Halma @MatthewHalma

Biophysicist | #Postviral syndromes, #longCOVID, #PACVS | Open Source Medicine Foundation | https://t.co/kWFDPz3ED2 Joined October 2022

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Matthew Halma @MatthewHalma

7 hours ago

@BiggoBuggo Halo Studios are being paid to make it worse. It would actually be cheaper to make a good remake over this.

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My rationale for picking the list is based off a) Metabolite is depleted in Long COVID b) Supplementation with metabolite improves symptoms c) Bonus points if depletion is also depleted in ME/CFS or similar post viral syndromes it may be possible that arginine increases viral replication, this is stronger in herpesvirus but possible in SARS-COV-2, the relationship is not well understood. I could see supplementation affecting viral replication if it was depleted to being a limiting factor. In that case I suppose it could make things worse.

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Matthew Halma @MatthewHalma

17 hours ago

🧵 Starting a 10-part series on the supplements with the best evidence for Long COVID / PACVS. Not wellness content, but published trials, mechanisms, and honest assessments of effect sizes. Starting with the strongest evidence and working through. Follow for the full series. 🔽

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Matthew Halma @MatthewHalma

16 hours ago

Turks have offered terms of surrender and reneged on them several times. Famagusta 1571: Venetian commander Bragadin surrendered on guarantees of safe passage. Ottomans flayed him alive, massacred the garrison & enslaved civilians. Otranto 1480: Promised quarter, then slaughtered ~12,000 Morea 1460: Multiple fortresses accepted terms, only to be killed/enslaved. Chios 1822: Systematic massacre & enslavement of 25k–50k Greeks.

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Matthew Halma @MatthewHalma

17 hours ago

Doses: L-arginine: 3.2g/day (split 2×/day in the Tosato trial) Vitamin C: 1g/day liposomal OpenSourceMed.info is studying L-arginine as part of a combined metabolic protocol specifically in PACVS — the vaccine-associated form of this syndrome. Follow the research: vitalscan4pacvs.com Tomorrow: #2. Creatine. Two RCTs, consistent signal.

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Matthew Halma @MatthewHalma

17 hours ago

The fatigue result deserves its own tweet. 8.7% still fatigued in the active group vs 80.1% in placebo. After 28 days, that's highly significant.

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Matthew Halma @MatthewHalma

17 hours ago

Cohen's d = 0.56 on the 6MWT (primary outcome) is considered a medium-to-large clinically meaningful effect. For reference: d = 0.2 = small d = 0.5 = medium (already clinically meaningful) d = 0.8 = large The arginine/ADMA restoration (d = 0.72) and endothelial function (d = 0.66) confirm the mechanism is actually working, not just symptomatic improvement.

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Matthew Halma @MatthewHalma

17 hours ago

Results at 28 days: 📊 Fatigue: reported by only 8.7% of the active group vs 80.1% of placebo (p<0.0001) 📊 6-minute walk test: Cohen's d = 0.56 (primary outcome — meaningful, sustained improvement) 📊 Endothelial function: Cohen's d = 0.66 📊 Serum L-arginine restoration: Cohen's d = 0.72 📊 Handgrip strength: Cohen's d = 0.37

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Angela McArdle @RealAngelaMc

a day ago

This man has done something incredibly important: he has ripped the bandaid off for mainstream creators to make right wing content. We must support him. He will start a movement.

UWE BOLL: RAW (Official) @UweBollRAWNet

a day ago

CITIZEN VIGILANTE is a small film I paid to get made. If you want a sequel, another Rampage film or anything else quite like this that takes chances topically you must put your money on it or I can’t afford to keep making them. If you support the film, actually support it by

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Sir James Britain🏴󠁧󠁢󠁥󠁮󠁧󠁿 @SirJBritain

3 days ago

I would give absolutely everything for the UK to look like this once again.

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Matthew Halma @MatthewHalma

3 days ago

@GashnorOfficial It's insane to see that game studios are INCAPABLE of including nearly 20 year old functionality that worked PERFECTLY in it's first iteration. You shouldn't have to show a game studio with a budget in the hundreds of millions how to implement a basic feature.

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Matthew Halma @MatthewHalma

3 days ago

@xor_a_b I hope that you get better. There are notable metabolite alterations in Long COVID which may translate to PACVS. sciencedirect.com/science/articl…

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Matthew Halma @MatthewHalma

3 days ago

Absolutely @SenRonJohnson , and it is my priority to advance the understanding of #PACVS through our organization opensourcemed.info. We are currently the ONLY research focused organization with a focus on getting support and acknowledgement for PACVS. Other orgs focus on patient Advocacy, which is an important part of the challenge. Ultimately we believe that by publishing rigorous research on PACVS in the peer reviewed medical literature this will necessarily raise the profile of PACVS and allow for funding allocation for treatment and research. At your service, Matthew Halma opensourcemed.info

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Sebastian Caliri @SebastianCaliri

6 days ago

I just tested my hand in a mini version of this scanner. Images that are higher quality than MRI, whole body captured in <1 minute, virtually free to run. This is going to change medicine. Things get even crazier when you consider the possibility of using the same tank to focus ultrasound to ablate tissue, stimulate nerves, etc. The FDA is not in the slightest ready for this. People will also complain about incidental findings but they are wrong and don’t understand how quickly software can improve and how inexpensive a time series of scans will be to generate.