Mehle Lab @MehleLab
Our contribution to understanding influenza virus. At UW Madison. @uwmadisonMMI mehlelab.com Joined June 2015-
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@CVRHutchinson @CVRinfo @RichardJOrton @CVR_Genomics @_chris_brooke And now we're live! Open access for the final version. academic.oup.com/nar/advance-ar… Thanks again @CVRHutchinson @_chris_brooke and Alistair Russell labs.
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@MollyOhainle Thanks. We talked about this how many years ago? Glad we could cite your work and show how TRPPC complements your PIKA approach.
We love genetic approaches to define virus:host interactions. Knockout screens are powerful, but...technical constraints limit what you can find. Could we devise a screen where viral fitness pinpoints the key regulators of replication? (spoiler - yes cell.com/cell-host-micr…) 1/10
Find more here 10/fin. x.com/cellhostmicrob…
Pathogen-driven CRISPR screening. @MehleLab develop transcriptional regulation by pathogen-programmed Cas9 (TRPPC) where viruses encoding sgRNAs alter host gene expression to affect their own fitness.TRPPC for influenza shows TREX1 tempers DNA self-sensing cell.com/cell-host-micr…
This was the result of tenacious work and deep thinking by Cason King, and offers a legacy that reflects who he was as a scientist. I thank other lab members and our collaborators in the labs of Judy Smith and @LangloisLab, and @BWFPATH for supporting risky science. 9/10.
Bittersweet final lab meeting with Jordan Ranum (white shirt). Jordan is off to med school at UW Madison. He joined as an undergrad and stayed as a scientist. Watch out for his amazing project on defective viral genomes that is about to drop.
@_colm_ @UWMadisonMDTP 🤷♂️ Gotta leave something bigger for the PhD defense.
It's been a busy work for the lab. Thomas (holding 🍾) passed his @UWMadisonMDTP qualifying exam with aplomb. Very excited to see him tackle his project as a dissertator. Congrats Thomas.
Excited to announce the successful thesis defense by newly minted Dr. @GraceSchaack (seen riding her thesis gift, a T-Rex). Great public presentation and closed-door defense. Super proud to have her as a lab alumna, and returning to the clinic to complete her MD. Congrats!
Mehle Lab retweeted
Congratulations to CMB Alums, Mitch Ledwith and Dan Tremmel, the 2022 Raymond L. Erikson Exceptional Thesis Award recipients! 🎉
@alimkell @BakerLabLBRI Fascinating topic. Great to see this @BakerLabLBRI. Congrats, and perfect launching pad for your group.
@virusninja @nyuniversity Thanks Ben. Fun day with an impressive group of microbiologist and thoughtful and engaged students. Learned a lot and really enjoyed the visit.
Mehle Lab retweeted
Studying how #influenza virus engages the cellular environment, @BakerLabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology plos.io/3VnlJS1
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