Mitchell Ho, PhD @MitchellHo
Antibody Engineer | Biochemist | Dedicated to Improving Human Health | Senior Investigator, National Cancer Institute (NIH) | Views My Own scholar.google.com/citations?user… Bethesda, MD Joined August 2009-
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🎉 It’s ON – CAR T day 2025 starts today! 📍 See you from 09:00 AM at the Faculty of Medicine – Research Center - 1 place de Verdun, 59000 Lille, France 🗓️ Check today’s highlights on the visual below 👇 For the full program 👉 cartday.org/program-2 Let’s kick off two days of inspiring discussions, cutting-edge science, and valuable connections in the CAR T field! 💬🧬✨ #CARTday #CARTday2025 #CARcells #Lille2025 #InternationalEvent #eventprofs @CHU_Lille - @univ_lille - @sfiimmunologie - @i_yakoub_agha - @DrOlivierBoyer
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @amanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…
🥳 Our 2nd most downloaded article in 2024: Cancer therapy with antibodies by Paul, Gabelli, @MitchellHo, van Elsas & colleagues bit.ly/4hXKvnw @JohnHopkins @theNCI @NIH @NatResCancer #NRCtop10of2024
It has been a great day! Thank you for inviting me to meet with wonderful faculty members and students at OSU and give a lecture at the Annual Meeting of the Pelotonia Institute of ImmunoOncology. @OhioStatePIIO @theNCI @NIH @IRPatNIH
Excited to feature Dr. @MitchellHo @NIH at #PIIO_2024 with his seminar: "Engineering #Antibodies and #TCells to Target #Glypicans in #Cancer". 6th Annual #PIIO Symposium.🧪✨
Honored to give a lecture at the Annual Meeting of the Pelotonia Institute of ImmunoOncology at Ohio State University @OhioStatePIIO @OSUCCC_James @Zihai @IRPatNIH @theNCI
Great talk from @MitchellHo @NIH on engineering antibodies and T cells to target glypicans in cancer. @OhioStatePIIO @OSUCCC_James
Register today for the Sixth Annual Pelotonia Institute for Immuno-Oncology (#PIIO) Symposium! go.osu.edu/io2024 Dec 2-3, Vitria on the Square, 14 E. 15th Ave, 2nd Floor, Columbus, OH 43201 (across from Ohio Union)
Proud to listen to Dr Dan Li @danli_502 present our work on engineering T cells to target GPC3 in HCC at #ILCA24. @NCIResearchCtr @IRPatNIH @NCI_Training
Fantastic opening session “Bench To Bedside: Emerging Therapeutic Targets” #ILCA24 by @Valeriechew29 @TimGreten Dr Greten and I discussed basic and clinical research on liver cancer immunotherapy @NCIResearchCtr @IRPatNIH
Glad to share our new paper describing the discovery of a camel nanobody that mimics a TCR targeting the pMHC complex derived from an intracellular HPV tumor antigen and the generation of CAR-T cells against cervical cancer. @CSHinrichsMD @NCIResearchCtr @IRPatNIH
CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer through NFAT and NF-κB signaling dlvr.it/TFCDSb
Happy to share our new research paper. We report for the first time the discovery of molecular interaction between GPC3 and AFP, both of which are specific proteins associated with liver cancer. @NCIResearchCtr @theNCI @IRPatNIH onlinelibrary.wiley.com/doi/10.1002/pg…
Honored and humbled to receive the Asian American Engineer of the Year award. Will be giving a lecture on engineering antibodies and T cells to target glypicans in cancer. #AAEOY @NCIResearchCtr
Let’s take a closer look at recent #JITC article: “rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors” by @MitchellHo & @danli_502 from @NCIResearchCtr & @NeoImmuneTech. 1/8
CAR T cells based on our humanized rabbit monoclonal antibody, called hYP218, targeting mesothelin epitope close to cell membrane, are very effective against mesothelin-positive tumors. @NCIResearchCtr @NIHClinicalCntr
Anti-mesothelin hYP218 Chimeric Antigen Receptor T Cells—read this article featured in the AACR Journals Collection on Developmental Therapeutics. bit.ly/3XlryUB @MitchellHo #openaccess
🚨Latest paper just hit in @JournalofNucMed 🚨 It's got... ✅Single domain Antibodies. ✅PET imaging. ✅#LiverCancer Buckle up! Thread time. 🧵 1/x jnm.snmjournals.org/content/early/…
Our new study demonstrates that combination of an engineered IL-7 and CAR-T cells targeting GPC3, GPC2, and Mesothelin can greatly enhance anti-tumor activity in liver cancer, pediatric cancer and ovarian cancer. @NCIResearchCtr @NeoImmuneTech @danli_502
New #JITC article: rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors bit.ly/4cQBue7 @MitchellHo
So proud of Laura Hutchins, a postbaccalaureate fellow in our lab @NCIResearchCtr @NIH_OITE, who was selected to give a talk #PEGSummit @PEGSboston for her work on a new antibody-directed TCR targeting GPC2 for treating neuroblastoma.
I am happy to share the latest review on cancer therapy with antibodies @NatureRevCancer @NCIResearchCtr. It was a pleasure to be part of the team led by Suman Paul and Shibin Zhou @JohnsHopkins
NEW content online! Cancer therapy with antibodies dlvr.it/T6rryP
Traveled to Beijing this week to give a keynote lecture at the Advanced Therapies Beijing Summit 2024. Had a great discussion with companies about collaborating on developing new cell therapies for treating liver cancer and other solid tumors.@NCIResearchCtr
@NCIResearchCtr @NIHClinicalCntr @theNCI Very honored to give a CCR Grand Rounds Lecture @NCIResearchCtr. Thank you to many colleagues @theNCI for joining in person or online! Looking forward to continued collaborations to use antibody and protein engineering for developing more active CAR-T and other immunotherapies
Very proud of Dr Dan li @danli_502, who received “Outstanding Postdoctoral Fellow Award” from Dr. Douglas R. Lowy @theNCI. She presented our new development of camel nanobodies and CAR-T cells targeting B7-H3 for treating cancer at CCR FYI Colloquium @NCI_Training @NCIResearchCtr
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