فترة محدودة، الشراء مجاني داخل التطبيق
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OneGLP
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يساعدك التطبيق 📱 على متابعة علاجات GLP‑1 مثل Mounjaro وWegovy وOzempic. تقدر تسجل الجرعات 💉، الوزن ⚖️، الأعراض، الشهية، والتغذية مع صور تقدمك 📸
لفترة محدودة، الشراء مجاني داخل التطبيق
⏎ iPhone ⏎ iPad
يدعم العربية
OneGLP
يساعدك التطبيق 📱 على متابعة علاجات GLP‑1 مثل Mounjaro وWegovy وOzempic. تقدر تسجل الجرعات 💉، الوزن ⚖️، الأعراض، الشهية، والتغذية مع صور تقدمك 📸 وتقارير توضح تطورك مع الوقت وتذكيرات لمواعيد الجرعات. 🗓️
apps.apple.com/us/app/oneglp-…
TRIUMPH-1 knee osteoarthritis results: in 574 people, WOMAC pain fell 73% at 12 mg versus 38% with placebo over 80 weeks. The 9 mg group was also around 70%.
TRIUMPH-1 sleep apnoea results: in 243 people with moderate-to-severe OSA, AHI fell by 36.1 events/hour at 9 mg, a 60.6% reduction. Placebo fell by 11.1 events/hour.
In the 104-week TRIUMPH-1 extension, the 12 mg pathway reached 30.3% average weight loss, about 38.5 kg from a 121.7 kg starting weight. This was a selected 532-person extension group.
TRIUMPH-1: 2,339 people. At 80 weeks, average weight loss was 19.0% at 4 mg, 25.9% at 9 mg and 28.3% at 12 mg. The more conservative treatment-regimen result at 12 mg was still 25.0%.
So the next Reta milestones are pretty clear: direct vs tirzepatide this year, US submission targeted for Q1 2027, the court decision still pending, and long-term maintenance data to follow.
Then there is TRIUMPH-6: 643 people, 80 weeks of Reta followed by 36 weeks of randomised maintenance. It should tell us much more about what happens after the main weight-loss phase.
One complication: Lilly and the FDA are still fighting over whether retatrutide should legally be treated as a drug or a biologic. The Seventh Circuit heard the appeal on 24 September. No decision yet.
TRIUMPH-1 gave us 28.3% average weight loss at 12 mg. SURMOUNT-1 gave 20.9% with tirzepatide 15 mg. But those were separate trials. TRIUMPH-5 is the one that can finally compare them properly.
The big one now is TRIUMPH-5: 800 people, Reta vs tirzepatide, head to head. Primary completion is expected in November 2026, with the full study finishing in December.
@NEJM 104 weeks!
At 104 weeks, average weight loss from the original starting weight was:
27.9% for people originally assigned to the 4 mg pathway.
29.5% for the 9 mg pathway.
30.3% for the 12 mg pathway.
reddit.com/r/RETA/s/BKWL6…
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