PoxReference @PoxReference
https://t.co/hU0hdBeiC1: Epidemiology, Transmission, Clinical Presentation, Diagnosis, Complications, Sequelae, Treatment, Vaccination, References Joined May 2014-
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Basic pharmacology, animal models and experience in human patients of three antiviral agents with activity against monkeypox: cidofovir, brincidofovir, and tecovirimat. doi.org/10.1093/cid/ci…
197 MPX cases in central London. doi.org/10.1136/bmj-20… All patients presented with mucocutaneous lesions (genitals: 56.3%; perianal area :41.6%). 86.3% reported systemic illness (fever, lymphadenopathy, myalgia). Fig 1: Progression of penile lesions and penile oedema.
Monkeypox Virus Infection in Humans across 16 Countries N Engl J Med. 2022 Jul 21. doi.org/10.1056/NEJMoa… By Thornhill JP, Barkati S, Walmsley S, et al.
Ophthalmic manifestations of monkeypox virus. By Abdelaal et al. Eye (Lond). 2022 July 27. nature.com/articles/s4143… A brief discussion of ophthalmic manifestations of monkeypox infection before the current epidemic.
@DrSebastianNoe @profchloeorkin @NEJM 👍👍👍
Stages of skin presentation and progression of monkeypox rash - darker and lighter skin pigmentation. From Titanji BK et a. Monkeypox: A Contemporary Review for Healthcare Professionals. Open Forum Infect Dis. academic.oup.com/ofid/article/9…
Distribution of tropical rainforest and 47 human monkeypox cases, 1970-79 (Breman 1980). Breman JG, Kalisa-Ruti, Stenovski MV, et al. Human monkeypox, 1970-79. Bull World Health Organ 1980;58:165-82. ncbi.nlm.nih.gov/pmc/articles/P…
doi.org/10.1016/j.tmai… All MPXV genomes grouped into three monophyletic clades, where the newly classified lineage B.1 includes all MPXV genomes from the 2022 outbreak. The authors estimate that the B.1 lineage emerged in Europe on 03/02/2022 [95%CI = 11/13/2021 to 05/10/2022].
Full text: doi.org/10.2807/1560-7… 12 patients, 147 clinical samples, real-time PCR. MPXV DNA was detected in saliva from all cases, sometimes with high viral loads. Other samples were frequently positive: rectal swab (11/12 cases), nasopharyngeal swab (10/12 cases), semen...
Spain outbreak. 30 of the 530 case-patients were hospitalized (median admission 2 days); 33 reported complications, mainly secondary bacterial infections (n = 15) oral ulcers (n = 11), proctitis (n = 2), and pharyngotonsillitis (n = 2). No deaths.wwwnc.cdc.gov/eid/article/28…
Noe S et al. Clinical and virological features of first human monkeypox cases in Germany. Infection 2022. doi.org/10.1007/s15010… The authors present clinical and virological findings of the first two cases of MPX infection in humans, including the detection of monkeypox virus...
Girometti N et al. Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London. Lancet Infect Dis. doi.org/10.1016/S1473-… The author’s describe the clinical characteristics of 54 individuals.
Nörz D et al. Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox. Euro Surveill doi.org/10.2807/1560-7… The authors successfully isolated monkeypox virus from three different samples, each with a total of at least 10^6 virus copies.
Selb R et al. A shift from travel-associated cases to autochthonous transmission with Berlin as epicentre of the monkeypox outbreak in Germany, May to June 2022. Euro Surveill. doi.org/10.2807/1560-7… In early July 2022, Germany has one of the highest overall number of MPX...
Iñigo Martínez et al: "Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022." Euro Surveill doi.org/10.2807/1560-7… The authors report 508 confirmed cases of monkeypox in the Madrid region of Spain, 99% of whom were men.
Kamps BS, Hoffmann C, et al. COVID Reference 2021.6. Steinhäuser Verlag 2021, 6th edition, 453 pages, published 13 January. Download: covidreference.com/download
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