ProNovus Bioscience @ProNovusBio
Membrane Protein Bioreagents, Gene-to-Protein CRO, Genetic Diagnostics pronovusbio.com Mountain View, CA Joined January 2013-
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And for more on applications of machine learning in drug discovery and development, here's a recent review go.nature.com/2GgbGuK
Just had coffee with a friend and biotech CEO. They’re moving operations out of the Bay Area and California entirely, decamping for sites back East, eg RTP. It’s gotten to the point where you have to be a Pharma or enjoy setting cash on fire to operate a lab in the Bay Area.
Deadly Superbugs Win as Wall Street Flees Makers of Antibiotics bloom.bg/304uzI8
Gene Hackers: The Young #Biotech #Entrepreneurs Looking To Make Billions By Editing Life Itself bit.ly/2Q3Vnok @ellie_kincaid @mtindera07 #geneediting #genomeediting #CRISPR #synbio @CaribouBio @eGenesisBio @mammothbiosci
#Biotech companies raised $16.8 billion in #venturecapital in 2018 compared to $12.1 billion in 2017. Additionally, the average amount per round of financing was 42 percent more than in 2017. fiercebiotech.com/special-report…
New computational tool enables powerful molecular analysis of biomedical tissue samples rna-seqblog.com/new-computatio…
The trickster microbes that are shaking up the tree of life, from @nature nature.com/articles/d4158…
Fascinating paper on changes in levels of mGlu5 in PTSD linked to suicidal thoughts. Potential biomarker and pathway for treatment. pnas.org/content/early/…
Fierce competition among biosimilar manufacturers in China, India and South Korea means they are outcompting Western biosimilar manufacturers in low-income markets go.nature.com/2PWYnmd
Antibiotic mechanisms are revealed by a white-box machine-learning approach that integrates biochemical screening and metabolic network modeling. #NBThighlight bit.ly/2HcX4eV
These 6 biotech stocks are promising takeover targets dlvr.it/R3xjly
.@NIH is seeking public comments on future plans for the #BRAINInitiative. Submit your input here: bit.ly/2Gl6fK5 #studyBRAIN
Great review on tractability of allosteric binding sites on GPCRs informed by x-ray structures ncbi.nlm.nih.gov/pubmed/30992500
“Everyone agrees that there is an absolute need for new antibiotics but there is no sustainable market,” @IFPMA’s Thomas Cueni warns on the growing threat of antimicrobial resistance. buff.ly/2LeTpmf
.@deevybee urges researchers to rein in the four horsemen of the reproducibility apocalypse: publication bias, low statistical power, P-value hacking and HARKing. go.nature.com/2L0zWpr
Two new studies report the first cryo-EM structures of a GABAA receptor in a physiological conformation and in complex with various drugs. These structures could provide the basis for future structure-based drug discovery. go.nature.com/2QD9wY7 @RaduAricescu and @MRC_LMB
Top product forecasts for 2019 @ByLisaU @evaluatepharma go.nature.com/2Hc7OO8
Researchers develop a method to investigate how bacteria respond to starvation and to identify which proteins bind to the “magic spot” — ppGpp. Explore in 3D at RCSB PDB: rcsb.org/structure/6CZF news.mit.edu/2018/mit-biolo…
Advanced biomaterials and drug delivery systems could improve the potency of cancer immunotherapies while reducing toxicities - find out more in this new review by Rachel Riley, Carl June, Robert Langer and Michael Mitchell go.nature.com/2TG3c4f
human TP bound to two antagonists, ramatroban and daltroban nature.com/articles/s4158… human EP3 bound to misoprostol-FA nature.com/articles/s4158… human EP3 bound to endogenous ligand PGE2 nature.com/articles/s4158… 今週のNCBはclass A GPCRの新規構造祭り。
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