Simon J. Clark @ProfClark
Helmut Ecker Endowed Professor of AMD & Co-Founder - Complement Therapeutics. A British Biochemist in Europe 🇬🇧 🇪🇺 @prof-clark.bsky.social eye-tuebingen.de/clark/ Tübingen, Germany Joined June 2021-
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Could pharma mega-mergers ultimately boost biotech M&A? Integration risk may push Big Pharma toward targeted acquisitions of differentiated, clinical-stage assets. #Biotech #M&A #Pharma buff.ly/vZnxuZj
It's pretty cool to finally see a method capable of generating practical amounts of functional, full-length complement factor H. buff.ly/xwEz6YD #ComplementTherapeutics #ComplementSystem #Immunology #DrugDevelopment #BiotechInnovation #TranslationalMedicine
Jasper-Kira merger highlights the next wave of complement therapeutics: dual-pathway inhibition and next-gen immune modulation could reshape treatment of complement-driven diseases. buff.ly/vjXHLY3 #Complement #Biotech #Immunology
New roadmap says the FDA aims within three to five years to make animal studies the exception, rather than the norm, in preclinical safety and toxicity testing. #DrugDevelopment #Biotech #RegulatoryScience #ClinicalTrials #FDA #NewApproachMethodologies buff.ly/7qPDRQP
Restoring lysosomal function prevents drusen-like deposits and RPE degeneration in inherited macular disease, revealing a promising therapeutic pathway with major implications for #AMD. #Retina #VisionResearch #Ophthalmology #CellBiology buff.ly/7Vqe4fF
J&J axes CD59 gene therapy for AMD after key phase 2b readout. buff.ly/tvD4LAE I'm not confident there was enough discussion with experts from the complement field when this strategy was devised. #AskTheExperts #AMD #complement #CD59 #therapy #phase2b #clinicaltrials
FHR proteins continue to show their importance in the pathology of disease, now including ANCA-Associated Vasculitis buff.ly/rRmSQRW and colorectal cancer buff.ly/LdZBQtM as well as AMD buff.ly/yGIMdEv #AMD #ANCA-AV #cancer #complement #therapy #FHR #FH
Functional mitochondria slow retinal degeneration in a dry #AMD model, reducing oxidative stress, inflammation & complement activation—pointing to a new cell-free therapy. #Retina #VisionResearch buff.ly/sUnDNlm
A novel ApoE⁻/⁻/Cfh⁻/⁻ mouse model captures key early AMD features, advancing research into disease mechanisms and preventive therapies. #AMD #Retina #VisionResearch #Immunology buff.ly/QBVqGSF
New data show OCT-based ellipsoid zone biomarkers predict geographic atrophy progression and that avacincaptad pegol slows photoreceptor degradation. #Ophthalmology #Retina #AMD #OCT #MedTech #Research buff.ly/bIkoziQ
Great to see people addressing the Bruch's membrane barrier issue when delivering complement inhibitors for GA and AMD! New Ab fragment against C3 developed by Boehringer Ingelheim. #AMD #GA #complement #C3 #drugdevelopment #antibody #therapy buff.ly/SYX0HiR
Choriocapillaris flow disruption emerges as a key driver of AMD, linking microvascular dysfunction to retinal degeneration and disease progression. #AMD #Retina #Ophthalmology #Choriocapillaris #OCT #VisionScience #AI #MedTech #PrecisionMedicine buff.ly/zPX12ap
AI-driven OCT phenotyping in AMD reveals new retinal biomarkers for risk stratification, advancing precision ophthalmology and future clinical endpoints. #AMD #Ophthalmology #AI #Retina #MedTech #DigitalHealth #VisionScience buff.ly/OMiC2G1
New insights into #GeographicAtrophy care: a study reveals how US retina specialists balance efficacy, safety & treatment burden in evolving #AMD management. #Retina #Ophthalmology #MedResearch buff.ly/8HCwo1G
Novel insight in #AMD research: a new spatially weighted model captures the true impact of #GeographicAtrophy beyond lesion size. A step toward smarter #Retina imaging. #Ophthalmology #MedTech #VisionScience buff.ly/pes2x9B
Very pleased to see our latest publication on 'Decoding the Factor H‐Related Proteins: Gatekeepers of Complement Dysregulation in AMD' is now published. Well done to Jiaqi Tang and Nathalie Zgoda! buff.ly/VtPSle2 #complement #AMD #immunology #ophthalmology #drugtargets
Could Ginkgo biloba help target complement dysregulation in dry AMD? New computational evidence identifies potential disease-relevant interactions. #AMD #DryAMD #VisionScience #DrugDiscovery buff.ly/4MPNPCw
New study identifies tissue-resident choroidal macrophages as key guardians against AMD, linking their loss to complement-driven retinal degeneration. #AMD #Immunology #Complement #Macrophages #Retina #Ophthalmology #VisionResearch #Aging buff.ly/JThGbjk
A distinct genetic AMD subtype emerges: rare CFH/CFI variants are linked to earlier geographic atrophy and severe drusen burden. #AMD #GeographicAtrophy #Genetics #PrecisionMedicine buff.ly/9Zjotxq
I'll be chairing a session at this years ISER meeting in Valencia on 'The role of opsonisation and phagocytosis in ocular immune homeostasis' 23rd to 27th August in Valencia Spain! buff.ly/hGELKaF #Ophthalmology #ISER #retina #AMD #phagocytosis #microglia #macrophage
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