The West Lab @SCWestLab
The West Lab @TheCrick studies mechanisms of DNA Recombination and Repair. Tweets by lab members, unless signed SCW. Views are own crick.ac.uk/research/labs/… London Joined December 2022-
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The West Lab retweeted
Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m
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The West Lab retweeted
We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home/
The West Lab retweeted
📣#RECOMBINATION25 PROGRAMME NOW LIVE! Exciting news! The first draft of the programme for the 2nd Recombination Mechanisms conference is now available. 🌟 🗓Important Deadlines: Early Bird & Talk Submission – 28 Nov 2024 Poster Submission & Registration Deadline – 13 Mar 2025 Don’t miss out—check out the programme and get all the details here: bit.ly/4ekGnMz
@Jiangchuan_Shen While we observed interaction between the N-terminus of RPA (DBD-F, DBD-A and DBD-B) with RAD52, it is dispensable for the stimulation we observed in the single-stranded DNA annealing assay (Extended Data 11g).
We are very excited today to share our work in @Nature defining the mechanism of human RAD52 mediated single-stranded DNA annealing in cooperation with replication protein A (RPA) nature.com/articles/s4158…. Thread ⬇️⬇️⬇️ (1/8)
The West Lab retweeted
Delighted to share that my manuscript of "Mechanism of single-stranded DNA annealing by RAD52-RPA complex" is now in Nature!
We are very excited today to share our work in @Nature defining the mechanism of human RAD52 mediated single-stranded DNA annealing in cooperation with replication protein A (RPA) nature.com/articles/s4158…. Thread ⬇️⬇️⬇️ (1/8)
This work was an incredibly collaborative effort between our group (@LukeGreenhough, @ilirjanabajrami @Tuppi1987), the fantastic facilities at the @TheCrick, and funded by @BBSRC and @ERC_Research
Our structural, biochemical and biophysical analyses provide a model by which human RAD52 open-ring cooperates with RPA to facilitate single-stranded DNA annealing repair. Our findings may provide new ways of targeting RAD52 in BRCA2 deficient tumours (7/8)
Looking forward to it!
@SCWestLab we're looking forward to your presentation at #DNARepair24 in Malta this October! 🇲🇹 Please RT to let your followers know you'll be speaking & that Early Bird & Talk Submission close on 02 May 2024. Find out more ➡️bit.ly/talksub_DNARep…
📣@TheCrick has launched The Translation Scholar 🎓 initiative, a new role that combines #AcademicResearch with #Entrepreneurship to bring technologies to market. Congrats to @lola_anaid for being the inaugural holder.🔬💼 We're also hiring! lnkd.in/dV-T2rxm
The West Lab retweeted
Congratulations to Caroline Hill and Xiaodong Zhang on being awarded almost £6 million in @wellcometrust Wellcome Discovery Awards to study DNA repair and organ development in zebrafish and humans 🥳 crick.ac.uk/news-and-repor…
Our latest paper uses structural biology, biochemistry & biophysics to reveal the two-step catalytic mechanism of the human nucleotide pool sanitiser DNPH1. This will aid the development of novel inhibitors, which may be of use in breast cancer treatment. nature.com/articles/s4146…
The West Lab retweeted
We awarded our annual Translation Prize last night, recognising researchers at the Crick who are applying their research in a real-world setting. Congratulations to our winner Anaid Benitez, runner-up Andreia Bernardo and all the nominees! 🏆🎉crick.ac.uk/news/2023-10-1…
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