ShenoyLab @ShenoyLab

We develop theoretical concepts and computational models - mechanobiology, matrix mechanics, nano- and energy- materials. Tweets by group members. @CEMB_STC shenoy.seas.upenn.edu University of Pennsylvania Joined June 2020

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ShenoyLab @ShenoyLab

a year ago

#EpigeneticRegulation #ChromatinDynamics #GenomicsResearch#EpigeneticMemory #CellFateDecisions #ChromatinRemodeling#CellBiology #SystemsBiology#GenomeBiology #ChromatinOrganization

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ShenoyLab @ShenoyLab

a year ago

6/6 🤝 Huge thanks to @ShenoyLab, @Melike_Lak, and @rp_mccord for the collaboration, and @CEMB_STC, the NCI MetNet - @NCIDCB! This work highlights the power of interdisciplinary science.

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ShenoyLab @ShenoyLab

a year ago

1/6 We built a sequencing-informed polymer model that integrates STORM, Hi-C, and RNA-seq to reveal how HC domains — especially their boundaries —regulate gene expression during drug treatment, microenvironmental changes, and cell fate transitions. doi.org/10.1038/s41467…

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Invadosome Consortium @invadosome

3 years ago

#FridayJClub

ShenoyLab @ShenoyLab

3 years ago

A new joint theory/experiment paper led by @ZeGongGreg just appeared in Nature Communications! We show how wave-like dynamics of immune cell podosomes arise from the coupling between chemo-mechanical signaling and actin diffusion. @CEMB_STC @PennEngineers nature.com/articles/s4146…

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The Linder Lab @LinderLab

2 years ago

Great news: the next meeting of the Invadosome Consortium (9th in this series) will take place in Vancouver, Canada, Oct. 01-04, 2024 Organizers: Karla Williams and Michael Olson Excellent science and beautiful nature, what´s not to like? ⚗️🌲 invadosome.com

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Chris Rodell @ChrisRodell2

2 years ago

Incredible speaker lineup uncludes @KoleRoybal, @NF_Steinmetz, @KWhiteheadLab, @NatalieArtzi, @LindaGGriffith1, @ManishButte, @Tang_Lab_UCSF, @ValerieJHorsley , @BellasFATLab, @taabaman, @ShenoyLab, @DoloffLab, @SantiCorreaPhD, @JennyNJiang, @gail_l_rosen, @veiseho and many more!

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Chris Rodell @ChrisRodell2

2 years ago

Come one, come all, I want to see you here this Fall! Register for #IMES2024! Trainees & early career investigators - submit your abstracts for a chance to win cash prizes and oral presentations! Travel Scholarships are available!🤑 Due: Oct. 1 Link: tinyurl.com/4swvjttr

Drexel School of Biomedical Engineering @drexelbiomed

2 years ago

🚨 Last Call: Abstract Submission Deadline Approaching! 🚨 #IMES2024 is the only conference dedicated to convergent research in translational immunology and engineering. 📅 Deadline: Oct. 1, 2024 Submit here: tinyurl.com/35uwzcj7 Learn more: tinyurl.com/IMES2024

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Materials Science and Engineering at Penn @MSEatPenn

2 years ago

This is what it's all about. @Penn @PennEngineers @MSEatPenn welcomes everyone.

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CEMB @CEMB_STC

2 years ago

What balances the size of heterochromatic domains in our cells? @ShenoyLab et al explore the interplay of methylated histones, acetylation, and RNA polymerase II-driven supercoiling. Check out the sophisticated model led by Aayush Kant on @NatureComms nature.com/articles/s4146…

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Ulrich Schwarz (also @ulrichschwarz.bsky.social) @SchwarzUlrich

2 years ago

Last day of the wonderful GRC on Signal Transduction by Engineered Extracellular Matrices #GRCSTEEM organized by Shelly Peyton and @kumarlabucb started with a session on multiscale modelling, with discussion leader Vivek Shenoy and first speaker @davidodde

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ShenoyLab @ShenoyLab

2 years ago

@Ella_Maru Thank you! Yes, that is what we show here. Substrate stiffness changes HDAC3 levels, which in turn alters the chromatin-lamina interaction strengths. Note HDAC3 is involved in "tethering" chromatin to the lamina.

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ShenoyLab @ShenoyLab

2 years ago

New preprint on integrating biophysical computational modeling with high-resolution imaging to predict how epigenetics and chromatin-lamina interaction energetics regulate the size and shape of lamina-associated domains (LADs)! biorxiv.org/content/10.110…

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ShenoyLab @ShenoyLab

2 years ago

Great @CEMB_STC collaborative effort with @Melike_Lak @HeoLab and @MauckLab led by Monika Dhankhar, Zixian Guo and Aayush Kant.

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ShenoyLab @ShenoyLab

2 years ago

Our findings reveal how chemo-mechanical environment cues such as changes in cell extracellular matrix stiffness affect not only the availability of epigenetic regulators but also the mechanosensitive binding of heterochromatin to the nuclear lamina.

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ShenoyLab @ShenoyLab

2 years ago

By observing the size and shape of LADs via high-resolution STORM imaging by our amazing collaborators @Melike_Lak @HeoLab and @MauckLab, we can quantitatively extract the biophysical parameters - epigenetic reaction rate and chromatin-lamina affinity.

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ShenoyLab @ShenoyLab

2 years ago

We theoretically show that the size scale of LADs is dictated by epigenetic reaction rates. On the other hand, LADs could be either discrete bead-like shaped or elongated and spread-out along the nuclear lamina depending on the strength of chromatin-lamina interactions.