Sho Goh Lab @ShoGohLab
We find out where RNA modifications are, what they do, how they do it and why that matters gohlab.org Joined May 2019-
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Sho Goh Lab retweeted
OMG, whoever runs this place is a genius troll
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Sho Goh Lab retweeted
I enjoy using IGV, but I need a more efficient tool for analyzing diploid genomes. So, I developed one for myself. It provides exceptional GPU acceleration, allowing me to uncover all essential information spanning six orders of magnitude. #bioinformatics #genomics #visualization
Quite an innovative question
1/n What fraction of the human genome is essential for cellular viability? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay @JShendure biorxiv.org/content/10.648…
This is why we need biomedical research
Presented at #ASCO26: Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results:
Sho Goh Lab retweeted
Presented at #ASCO26: Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM @ASCO
I... this is... wait what?
Okay, I made an Atlas of Cell Atlases. Will post code later.
Sho Goh Lab retweeted
Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. nature.com/articles/s4158…
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our @MicahGoldrich and Louis Delhaye from @pieter_mestdagh. TL;DR we show that many of lncRNA chromatin occupancy maps are flawed🧵biorxiv.org/content/10.110…
Sho Goh Lab retweeted
Probably Craig Venters last interview. The people who drone on about the necessity of NIH “basic science” are the duds and dropouts of the class. It’s food stamps for the underachievers.
Sho Goh Lab retweeted
Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics go.nature.com/4tjA7MI
Achievement unlocked: 1st PhD graduated from the Goh lab, Dr. @huihuian521
Sho Goh Lab retweeted
omg this title, this paper
Sho Goh Lab retweeted
@fchollet You are my AI hero. However, I disagree about biology. At this moment, we need more high-quality data, the proper measures, and relevant questions. I actually wrote about this earlier today x.com/msikic/status/…
Saturday mornings are ideal for contemplating AI in biology. It’s one of the most important frontiers for AI—but we can’t just copy what works for text or images. Biology speaks a different language. Right now, two major directions are emerging... 1/6
Sho Goh Lab retweeted
Our new discovery that bacteria utilize extracellular vesicles to deliver RNAs into fungi substantially broadens the paradigm of Cross-Kingdom RNA communication! Big congrats to @J_NinoSanchez, @HuaitongW and all! Thanks for your hard work! cell.com/molecular-plan…
@hailingj1 @J_NinoSanchez @HuaitongW Congratulations Hailing!
Just finished giving the last talk at this amazing Asian RNA Club Symposium that was full of other talks and posters with new unpublished stories. Looking forward to the next Symposium in 2 years at Nara, Japan!
アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！
Sho Goh Lab retweeted
アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！
I was amazed by this tour de force to profile 16 different RNA modifications simultaneously when i first heard @SchragaSchwartz talk about it. I'm still amazed now. cell.com/cell/abstract/…
Cool teacher's day gift from my amazing PhD students!
Always great to have old friends visit us in SZ. Today, fellow HannonLab alumnus @Elvin_Wag from @IcahnMountSinai visited us at @ShenzhenBayLab to share his experience researching cancer stem cells, give career advice to our young scientists and enjoy our famous roast pigeon
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