StainsFile @StainsFile
Let’s talk about visualizing cells! 👩🏽🔬🔬 We’re an online resource for open-access protocols, reagents, theory, and more. Brought to you by @STEMCELLTech. stainsfile.com Joined October 2019-
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Looking to deepen your understanding of staining chemistry and tissue visualization? Learn about the ins and outs of trapping agents to help you maintain control and precision when preparing a sample for the microscope. 🔬 bit.ly/43oyMco
🤩 New review alert! Primary carcinomas of the vagina are uncommon tumors, accounting for <1% of female cancers. In this review, researchers discuss primary vaginal #adenocarcinomas and provide practical points for the #pathologist in typing and reporting: bit.ly/3ReKpQC
🧬 Multiplex IHC is transforming how #histology labs visualize and analyze tissue samples. By using multiple primary antibodies on a single slide, labs can gain deeper insights while conserving tissue. Learn about the pros and cons of IHC techniques: bit.ly/42Np5Eo
Enter your best cell image by 11:59 a.m. PDT on June 29 for a chance to win prizes! The 20 top-voted images will receive a magnetic puzzle of their image. 🧩 bit.ly/4vwBmcH
How can AI accelerate discovery? In this episode of the Lab Coats & Life podcast, Dr. Cesar de la Fuente explores how AI is transforming research. 🎧 Listen to learn how AI could be your new lab assistant at the bench or microscope: bit.ly/4fzWPfO #SciencePodcast
Is serrated epithelial change (SEC) a form of dysplasia? 🤔 According to a new @UofCalifornia study, the absence of aberrant, strong p53 staining in most cases of SEC, regardless of association with dysplasia, may argue against it. Abstract: bit.ly/4fAKJDb #Pathology
New in #HumPathol: Histologic Spectrum of BRCA-Associated Pancreatic Ductal Adenocarcinoma: A Descriptive Morphologic Study. sciencedirect.com/science/articl… #pathology #PathTwitter #PathX #GIpath #pancpath
Using a powerful single-molecule imaging method they developed, a @broadinstitute research team has unveiled a dynamic view of how some cancer-related proteins interact in living cells. 📰 News: bit.ly/4f1OfpZ 🥼 Abstract in @CellPress: bit.ly/3RnSvq2
The #StemCellfie contest by @STEMCELLTech is back! This June, we’re celebrating the beauty of cells and imaging excellence. Start prepping your brightest, boldest, most eye-catching microscopy shots for a chance to shine. 🔬 Enter your image here: bit.ly/4vGiTdt
Congratulations to Christine Holt, Kelsey Martin, Erin Schuman, and Oswald Steward, winners of the 2026 Kavli Prize in Neuroscience. Their discoveries revealed how neurons make proteins locally to support brain development, learning, and plasticity. #KavliPrize
A new detailed analysis of the #histopathology of the tongue in the A17/+ mouse model opens new avenues for understanding the mechanisms of #dysphagia. Check out the work from the Raz lab at @UniLeidenNews in @AJPathology: bit.ly/4uZIoWR
🔬 Great embedding starts with the right tools and techniques. From molds and tampers to biopsy bags and tissue orientation, every detail matters when avoiding common #histology pitfalls. Get all the tips you'll need to ace your next embedding session: bit.ly/4f6g4O5
🧠 Working with delicate neural #organoids? Proper cryogenic tissue processing is critical for preserving structure and viability. Check out this protocol for the best way to fixate, cryoprotect, embed, snap freeze, and cryosection your samples: bit.ly/4nGVupJ
The Huber lab at @UofR is helping labs become more efficient. They looked at gomori methenamine silver stains and determined that the standard two levels of #staining are not necessary in the majority of positive cases. 📝 bit.ly/4nETdLv
New this month in JHC: "Two-step Gelatin Embedding Preserves Fibrocartilage Morphology, Enthesis, and Cartilage Stain of Bone Joints." Click to read: journals.sagepub.com/doi/abs/10.136… #cartilage #histology #immunostaining
A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution @michalj @ScienceMagazine 2024 science.org/doi/10.1126/sc… H01 - 3D serial section scanning electron microscope data (4 nm resolution) of 1.05 mm3 human brain (left anterior middle temporal gyrus, epileptic) h01-dot-neuroglancer-demo.appspot.com
CryoPRISM is a new tool from researchers at @MIT for observing cellular machinery in a natural environment. Dr. Joseph Davis, the study's lead, says that cryoPRISM is the sweet spot between preserving native structures and high resolution: bit.ly/3Peojx2 #Microscopy
Bread and butter post: Inflammatory cloacogenic polyp is a mucosal prolapse polyp at the junction of rectal glandular mucosa and anal squamous mucosa. Note that the the lamina propria is filled with smooth muscle rather than the usual complement of inflammatory cells.
Before tissues can be stained and studied, they need to be preserved and that’s where fixatives come in. Selecting the appropriate fixative is an essential step in the staining process to ensure the foundation of your microscopy session is solid. Check out this database of fixatives to make sure you always choose right: bit.ly/3PB0TBS #HistologyResource
Take a look at these fluorescent egg chambers from the ovary of a fruit fly. Isn't the geometric nature of biology incredible?! #FluorescenceFriday bit.ly/4v80ia8 Credit: Dr. Yujun Chen
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