Mariano Labrador @TheLabradorlab
Associate Professor at The University of Tennessee, Knoxville. Molecular Biology. Genome function Joined August 2020-
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Mariano Labrador retweeted
So there is a 'gala' 👩❤️👨 between phosphorylated Histone H2Av and chromatin insulators. Our new paper biorxiv.org/content/10.110… addresses this synergy and demonstrates its possible role in Drosophila genome organization.
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and it aligns with other insulator proteins at TAD boundaries flanking developmentally regulated genes
Pospho-H2AV is found at TAD boundaries in the Drosophila genome
More on the link insulators and genome stability! Our lab just posted a BioRxiv pre-print showing the Phosphorylated Histone H2Av, the H2A variant equivalent to Phospho-H2AX in mammals, displays properties of insulator proteins in Drosophila biorxiv.org/content/10.110…
Check out our recent paper showing that mutations in Drosophila insulator proteins lead to genetic instability in vivo, both in germ line and developing brain, emphasizing the intriguing connections between architectural proteins and genome stability. link.springer.com/article/10.100…
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