Alvaro Sanchez-Martinez @alsanchezmar
Senior Research Associate at @Cambridge_Uni @MRC_MBU with interest in the mechanisms underlying mitochondrial homeostasis in neurological diseases. Cambridge, England Joined May 2015-
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🚨 Calling all researchers in neurodegenerative diseases! 🚨 Submit your manuscript & join EMP in shaping the future of biomedical research. sciencedirect.com/journal/experi… @ELSpharma #NeurodegenerativeDiseases #CallForPapers #BiomedicalResearch #Pharmacology #pathtwitter #Elsevier
Invitation to researchers specializing in Metabolism!📰 Submit your manuscript now and be part of EMP’s mission to advance biomedical research🤓 sciencedirect.com/journal/experi…… @ELSpharma #Metabolism #CallForPapers #BiomedicalResearch #Pharmacology #pathtwitter #Elsevier
🚨Attention Molecular Biology Researchers🚨 Submit your manuscript to EMP & contribute to advancing cutting-edge biomedical research! Learn more about our expanded scope here: sciencedirect.com/journal/experi… @ELSpharma #MolecularBiology #CallForPapers #BiomedicalResearch #Elsevier
Paper alert. Insights on papers published in our special research topic on #mitochondria and #neurodegenerative_diseases, volume II @FrontNeurosci. Great collaborating with you @alsanchezmar @Federica_DeLazz @gloriabreacalvo Thanks to the reviewers too! frontiersin.org/journals/neuro…
We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo nature.com/articles/s4146…
New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @kei_sakamoto @CarolMacKintos1. See it here: tinyurl.com/AMPK-ULK
Does a transmembrane sodium gradient control membrane potential in mam... sciencedirect.com/science/articl…
New study from us: science.org/doi/10.1126/sc… High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.
Inspiring science at the Postdoc Networking Day yesterday at @AstraZeneca. Happy to have contributed to this wonderful event with the Cambridge Biomedical Campus and @AstraZeneca. Huge thanks to Jonathan Lawson for organising this gathering. The MBU Postdoc Society
Please have a look at our recent review on mito-dynamics!
Thrilled to share the last review of the lab led by @Tabara_LC and @MayukoSegawa on the mechanisms regulating mitochondrial morphology!!! @MRC_MBU Just out in @NatRevMCB. Thanks @lisa_heinke for the smooth editorial process!
A small gift to celebrate the Postdoc Appreciation Week!! 😊 Thank you all for your great work and commitment to science! 🔬 The MBU Postdoc Society @MBU_postdocs @MRC_MBU (thank you @MariangelaDiony for your help 😉)
📣New @biorxivpreprint from @mito911_! @Basak94Bishal & @ErikaHolzbaur present a new stress response pathway regulating #mitophagy in #neurons through degradation of the autophagy negative regulators MTMR5/2 and Rubicon @ASAP_Research @MichaelJFoxOrg biorxiv.org/content/10.110…
Thrilled to announce that our project has been published in @CellCellPress. In this work, we link mitochondrial dynamics to mitochondrial quality control and mtDNA maintenance by characterizing the molecular function of MTFP1. Please DM; happy to discuss! cell.com/cell/fulltext/…
We’re hiring! The Whitworth lab (Mitochondrial Neurodegeneration) is recruiting a postdoc to work on mechanisms of #calcium and #iron handling on #mitophagy in mouse or iNeuron models of neurodegeneration. jobs.cam.ac.uk/job/46870/ mrc-mbu.cam.ac.uk/research-group…
Delighted to share the last study of the lab led by the fantastic postdoc @Tabara_LC out in @CellCellPress !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. @MRC_MBU @Cambridge_Uni authors.elsevier.com/sd/article/S00…
Congrats to our PhD student @lucialugut on the selection of her abstract for presentation at #DMMgenetics in Edinburgh! 🎓 #PhD @MRC_MBU @MRCMitoCluster @MRCMouseNetwork
Thrilled to present some of my PhD results at the #DMMgenetics meeting today in the beautiful Edinburgh 🏰🧬
Read our new study: nature.com/articles/s4225… Treatment of obese mice with small molecule inhibitors of mtDNA transcription (IMTs) leads to marked beneficial metabolic effects. The weight is normalized, the fat deposition in liver disappears and glucose homeostasis is normalized.
Our study is finally out! nature.com/articles/s4153… We here show that PARKIN is dispensable for OXPHOS function in adult mouse tissues and in skeletal muscle from a PD-patient. Thanks to @mitopinionated , @LabMotori, @perlmannlab and Per Svenningsson for the great collaboration!
Our new review exploring how CRISPRi can and will be used in iPSC models to understand neurodegeneration is available now in Biochemical Society Transactions doi.org/10.1042/BST202…
Thrilled to share our last work online today Here we highlight the central role of the retromer extracting mtDNA. biorxiv.org/content/10.110…
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