sk @compchemm
Computational Structural Biologist | Joined April 2017-
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This event is a global talent-screening or intelligence-gathering exercise in "protein design".
To show what these optimizations make possible, we’re partnering with Adaptyv Bio on a protein design competition. Together, we’ll be experimentally validating over 5,000 designs. We're providing up to $1 million in Claude credits plus funding alongside Adaptyv for experimental
@sokrypton is it possible to have more ions also. Can we contribute in the code.
sk retweeted
ColabFold2 Sneak Peak - integrates: alphafold3, openfold3, intellifold2, protenix2, boltz2, opendde, rosettafold3, chai1, esmfold2, openbind0 (thx Julia Buhmann), fully in Jax! 🗒️ Colab Notebook colab.research.google.com/github/sokrypt… 🐍 pip install gist.github.com/sokrypton/7565… (2/3)
@DavidRBellamy The real risk is from well-resourced state.
sk retweeted
I must be among an extremely small group of people (n=1?) that have both 1) trained a frontier LLM and 2) designed and synthesized custom viruses in a lab with my own two hands. And I think that the takes on AI killing us all by creating dangerous viruses is total bogus.
@DdelAlamo Another nice example is here doi.org/10.1038/s41586…
Cute Bicyclic peptides😂 doi.org/10.26434/chemr… doi.org/10.1002/pep2.2…
@AjasjaLjubetic Anthropic have endless cash & compute. It feels like just a matter of time before they eat up small-med biotech. They're actually pushing them to integrate & adapt LLMs and when times come they'll pull the trigger. Isomorphic already saw it coming & jumped in early.
All those protein design startups and co-founded companies at UW are gone 😅
Many drugs work by binding to a specific target in the body and blocking or changing what it does. An important first step in the drug development process is designing a molecule that can bind tightly to its target. Traditionally, that's meant weeks or months of expert work per
sk retweeted
Not to throw shade but I’m not sure I buy the argument that this is an example of agents “reducing the burden of human expertise” when the prompt used to kick things off is like ten pages long and looks like this. How many humans on earth know all these methods? Maybe 5,000 tops?
sk retweeted
To me it seems silly everyone is trying to automate their tasks with LLMs. Wouldn't it make more sense to use LLMs to develop better workflows for their tasks that do not require calls to LLMs? 🤔
So human-written protocol prompts handed to Claude and the skew towards the 7 starred mandatory(design tools) was baked in upstream.
@ZhengyangG51844 We got 6/10 designs in nM to a highly polar hotspot using bindcraft. Only 1 showed effect invivo & invitro, others are still in the queue.
@ZhengyangG51844 Quoting you “success” doesn’t just mean binding — it means having an actual inhibitory effect inside cells" - thats success not success rate😅
His entire work is behind paywall - rip academia
@BrinedewBio I think you would like the white one, but the blue is a bit more thick and modern.
Found our forever style for protein structures. Color palette looks great, β-sheets are crisp, and it’s officially locked in for our preprint. limewire.com/d/UV5o2#eGb8vT…
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