Countagen @countagen

Beautiful work from our HorizonEU consortium led by @dlwagner13 and his world-class Berlin team. 90% CAR knock-in with ssDNA templates 😳 Almost couldn’t believe it until we independently produced a batch of ssDNA donor template and replicated it in our own lab. Preprint link 👇

Dimitrios L. Wagner @dlwagner13

2 years ago

Preprint alert 🚨 Up to 90% CAR knock-in rates in primary human T cells - without drug enhancers? 🧐 Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells biorxiv.org/content/10.110… 🧵👇

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CMN Live: CRISPR next frontier: in vivo editing of the microbiome x.com/i/broadcasts/1…

𝐕𝐨𝐫 𝐁𝐢𝐨 𝐀𝐧𝐧𝐨𝐮𝐧𝐜𝐞𝐬 𝐏𝐨𝐬𝐢𝐭𝐢𝐯𝐞 𝐂𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐃𝐚𝐭𝐚 𝐅𝐫𝐨𝐦 𝐓𝐫𝐢𝐚𝐥 𝐨𝐟 𝐓𝐫𝐞𝐦-𝐜𝐞𝐥 𝐅𝐨𝐥𝐥𝐨𝐰𝐞𝐝 𝐛𝐲 𝐌𝐲𝐥𝐨𝐭𝐚𝐫𝐠 𝐢𝐧 𝐀𝐜𝐮𝐭𝐞 𝐌𝐲𝐞𝐥𝐨𝐢𝐝 𝐋𝐞𝐮𝐤𝐚𝐞𝐦𝐢𝐚 Last week, Vor Bio announced new, encouraging clinical data from the ongoing Phase 1/2 VBP101 trial of trem-cel followed by the anti-CD33 antibody-drug conjugate Mylotarg in patients with relapsed or refractory acute myeloid leukaemia. The data demonstrated early evidence of patient benefit, an increased therapeutic window for Mylotarg, and effective shielding against Mylotarg on-target toxicity. Read our summary of the update here 👇🏻 crisprmedicinenews.com/news/vor-bio-a… #crisprmedicinenews #crisprmedicine #crispr #antibodydrugconjugate #cancertherapy #crisprtrial #clinicalnews #geneediting

𝐖𝐚𝐧𝐭 𝐭𝐨 𝐥𝐞𝐚𝐫𝐧 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐩𝐫𝐢𝐦𝐞 𝐞𝐝𝐢𝐭𝐢𝐧𝐠? Then look no further! In this CRISPR Medicine News explainer, we tackle the folllowing: 📍What is prime editing and what is it used for? 📍What are the components of a prime editor? 📍How does prime editing work? 📍How has prime editing been used so far? 📍What are the limitations of prime editing? This explainer was written by Manel Llado Santaeularia, PhD. of WeDoCrispr with expert input from Dr. Jakob Hansen Haldrup, Radcliffe Department of Medicine, University of Oxford. crisprmedicinenews.com/news/explainer… #crisprmedicinenews #crisprmedicine #crispr #geneediting #primeediting #genomeediting #explainer

What a fantastic day of jam-packed sessions to kick off the ISCT Europe 2024 Regional Meeting. Today was filled with insightful sessions covering critical topics, from investment trends in Europe to advancements in iPSCs, innovations in TIL therapy, and CGT manufacturing.

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#ISCTEU2024

We are sharing exciting updates about GeneAbacus at the @ISCTglobal , International Society for Cell & Gene Therapy Europe 2024 Regional Meeting in Gothenburg, Sweden!🧬🧮 Join us TODAY at 6.30 pm, Poster No. 35. Don’t miss this opportunity to learn more! 🔥 #GeneTherapy

@countagen is thrilled to attend the 10th Genome Engineering: CRISPR Frontiers meeting at Cold Spring Harbor Laboratory @CSHL ! Meet you at Poster No. 145! @CSHLmeetings #cshlcrispr24 #countagen #geneabacus #CRISPR

🎉 Exciting news! Our latest work is now published in @Dev_journal! The open-source solution for RNA-targeted in situ sequencing provides an accessible and efficient method for spatially resolved gene expression analysis and spatial multi-omics. 🔗 doi.org/10.1242/dev.20…

⌛ Don´t miss the deadline!! 📢 @GeneHumdi ( COST Action CA21113) is willing to support ITC/NCC presenters in the upcoming international conferences and meetings. 🚀 Visit our latest call genehumdi.eu/genehumdi-2024… 👁 and check if you qualify!!

📢 @GeneHumdi ( COST Action CA21113) is willing to support ITC/NCC presenters in the upcoming international conferences and meetings. 🚀 Visit our latest call genehumdi.eu/genehumdi-2024… and check if you qualify. 👁 Keep and eye on the deadlines and apply soon!

TELL YOUR FRIENDS ‼️ 🧬@Genehumdi 2nd #STMS call aiming to help young researchers and early career professionals visit and collaborate with leading scientists across Europe will be receiving applications until August 24th. Learn more here: genehumdi.eu/2nd-2024-geneh…

#GeneAbacus was put to the test. ✅ Our customer discriminated single base edits with confidence, all within 5 hours, saving cost and time by skipping the need for assay optimization. Interested in using GeneAbacus? Reach out at [email protected]. #GeneAbacus #HighSpecificity

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𝐆𝐞𝐧𝐞 𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐢𝐧 180 𝐒𝐞𝐜𝐨𝐧𝐝𝐬 ⏳ 📹 Check out the new video content at WeDoCRISPR! Two of our favourite gene-editing gurus Manel Llado Santaeularia and Antonio Carusillo have launched "Gene Editing in 180 Seconds" - a new series where selected publications will be summarised in just 3 minutes! In the first instalment, you will learn about eePASSIGE, the novel gene-editing technology developed by the lab of David R. Liu at the Broad Institute of MIT and Harvard. Check it out 👇🏻 #wedocrispr #CRISPR #geneediting #eePASSIGE #bioengineering #DNA #primeediting #recombinase #proteinevolution #science #sciencedigest

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

⚠️Last seat available for our @genehumdi webinar June 25th at 3 pm CET. Expert, Paula Rio @PauFerrol , will discuss "CRISPR Clinical Trials: current progress and future perspectives in in vivo approaches.” register last minute at @CrisprMedicine crisprmedicinenews.com/cmn-webinars/g…

⚠️ The webinar is almost here!! 🧐Smart up an claim NOW your last minute seat!! 🚀 The @GeneHumdi YR Webinar Series is hosting #AnnaritaMiccio @Inserm 🚨Sign now with @CrisprMedicine to participate for Free in this COST initiative. ✏ crisprmedicinenews.com/cmn-webinars/g…

In chapter three of our series, we learn Shanna’s twins inherited not only hereditary angioedema (#HAE) and its associated challenges, but also their parents’ incredible resiliency. The family faces HAE together — through good days and bad. #GenomeJourney

⚠ ONLY ONE WEEK FOR MARC GÜELL WEBINAR!! ⚠ It will be the opening of the GeneHumdi Young Researcher Webinar Series 🎉 😍 Are you not excited?? and more important: ⁉ Did you already sign up??!! if you didn´t: DO IT NOW❗ It is free , do it here: crisprmedicinenews.com/cmn-webinars/g…