We pioneer cutting-edge solutions to streamline gene editing validation and accelerate the journey from discovery to practical use for Cell & Gene Therapies.countagen.com stockholm, swedenJoined September 2023
Beautiful work from our HorizonEU consortium led by @dlwagner13 and his world-class Berlin team. 90% CAR knock-in with ssDNA templates ๐ณ
Almost couldnโt believe it until we independently produced a batch of ssDNA donor template and replicated it in our own lab. Preprint link ๐
Preprint alert ๐จ
Up to 90% CAR knock-in rates in primary human T cells - without drug enhancers? ๐ง
Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells
biorxiv.org/content/10.110โฆ
๐งต๐
๐๐จ๐ซ ๐๐ข๐จ ๐๐ง๐ง๐จ๐ฎ๐ง๐๐๐ฌ ๐๐จ๐ฌ๐ข๐ญ๐ข๐ฏ๐ ๐๐ฅ๐ข๐ง๐ข๐๐๐ฅ ๐๐๐ญ๐ ๐ ๐ซ๐จ๐ฆ ๐๐ซ๐ข๐๐ฅ ๐จ๐ ๐๐ซ๐๐ฆ-๐๐๐ฅ ๐ ๐จ๐ฅ๐ฅ๐จ๐ฐ๐๐ ๐๐ฒ ๐๐ฒ๐ฅ๐จ๐ญ๐๐ซ๐ ๐ข๐ง ๐๐๐ฎ๐ญ๐ ๐๐ฒ๐๐ฅ๐จ๐ข๐ ๐๐๐ฎ๐ค๐๐๐ฆ๐ข๐
Last week, Vor Bio announced new, encouraging clinical data from the ongoing Phase 1/2 VBP101 trial of trem-cel followed by the anti-CD33 antibody-drug conjugate Mylotarg in patients with relapsed or refractory acute myeloid leukaemia.
The data demonstrated early evidence of patient benefit, an increased therapeutic window for Mylotarg, and effective shielding against Mylotarg on-target toxicity.
Read our summary of the update here ๐๐ป
crisprmedicinenews.com/news/vor-bio-aโฆ#crisprmedicinenews #crisprmedicine #crispr#antibodydrugconjugate#cancertherapy#crisprtrial #clinicalnews#geneediting
๐๐๐ง๐ญ ๐ญ๐จ ๐ฅ๐๐๐ซ๐ง ๐ฆ๐จ๐ซ๐ ๐๐๐จ๐ฎ๐ญ ๐ฉ๐ซ๐ข๐ฆ๐ ๐๐๐ข๐ญ๐ข๐ง๐ ?
Then look no further! In this CRISPR Medicine News explainer, we tackle the folllowing:
๐What is prime editing and what is it used for?
๐What are the components of a prime editor?
๐How does prime editing work?
๐How has prime editing been used so far?
๐What are the limitations of prime editing?
This explainer was written by Manel Llado Santaeularia, PhD. of WeDoCrispr with expert input from Dr. Jakob Hansen Haldrup, Radcliffe Department of Medicine, University of Oxford.
crisprmedicinenews.com/news/explainerโฆ#crisprmedicinenews #crisprmedicine #crispr#geneediting#primeediting#genomeediting#explainer
What a fantastic day of jam-packed sessions to kick off the ISCT Europe 2024 Regional Meeting. Today was filled with insightful sessions covering critical topics, from investment trends in Europe to advancements in iPSCs, innovations in TIL therapy, and CGT manufacturing.
We are sharing exciting updates about GeneAbacus at the @ISCTglobal , International Society for Cell & Gene Therapy Europe 2024 Regional Meeting in Gothenburg, Sweden!๐งฌ๐งฎ
Join us TODAY at 6.30 pm, Poster No. 35. Donโt miss this opportunity to learn more! ๐ฅ
#GeneTherapy
๐ Exciting news! Our latest work is now published in @Dev_journal!
The open-source solution for RNA-targeted in situ sequencing provides an accessible and efficient method for spatially resolved gene expression analysis and spatial multi-omics.
๐ doi.org/10.1242/dev.20โฆ
โ Donยดt miss the deadline!!
๐ข @GeneHumdi ( COST Action CA21113) is willing to support ITC/NCC presenters in the upcoming international conferences and meetings.
๐ Visit our latest call genehumdi.eu/genehumdi-2024โฆ
๐ and check if you qualify!!
๐ข @GeneHumdi ( COST Action CA21113) is willing to support ITC/NCC presenters in the upcoming international conferences and meetings.
๐ Visit our latest call genehumdi.eu/genehumdi-2024โฆ and check if you qualify.
๐ Keep and eye on the deadlines and apply soon!
TELL
YOUR
FRIENDS
โผ๏ธ
๐งฌ@Genehumdi 2nd #STMS call aiming to help young researchers and early career professionals visit and collaborate with leading scientists across Europe will be receiving applications until August 24th. Learn more here: genehumdi.eu/2nd-2024-genehโฆ
#GeneAbacus was put to the test.
โ Our customer discriminated single base edits with confidence, all within 5 hours, saving cost and time by skipping the need for assay optimization.
Interested in using GeneAbacus? Reach out at [email protected].
#GeneAbacus#HighSpecificity
๐๐๐ง๐ ๐๐๐ข๐ญ๐ข๐ง๐ ๐ข๐ง 180 ๐๐๐๐จ๐ง๐๐ฌ โณ
๐น Check out the new video content at WeDoCRISPR!
Two of our favourite gene-editing gurus Manel Llado Santaeularia and Antonio Carusillo have launched "Gene Editing in 180 Seconds" - a new series where selected publications will be summarised in just 3 minutes!
In the first instalment, you will learn about eePASSIGE, the novel gene-editing technology developed by the lab of David R. Liu at the Broad Institute of MIT and Harvard.
Check it out ๐๐ป
#wedocrispr#CRISPR#geneediting#eePASSIGE#bioengineering#DNA#primeediting#recombinase#proteinevolution#science#sciencedigest
What if we could universally recombine, insert, delete, or invert any two pieces of DNA?
In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
In chapter three of our series, we learn Shannaโs twins inherited not only hereditary angioedema (#HAE) and its associated challenges, but also their parentsโ incredible resiliency. The family faces HAE together โ through good days and bad. #GenomeJourney
โ ONLY ONE WEEK FOR MARC GรELL WEBINAR!! โ
It will be the opening of the GeneHumdi Young Researcher Webinar Series ๐
๐ Are you not excited??
and more important:
โ Did you already sign up??!!
if you didnยดt: DO IT NOWโ
It is free , do it here:
crisprmedicinenews.com/cmn-webinars/gโฆ
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Synthesizers - Consumables - Service
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6K Followers 479 FollowingGenome editing, functional genomics, and cells figuring out how to eat themselves without dying. Professor of Genome Biology at ETH Zรผrich.
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158 Followers 866 FollowingBiolyticยฎ Lab Performance, Inc. designs, manufactures and sells the most advanced DNA RNA oligo synthesizers in the world.
Synthesizers - Consumables - Service
556 Followers 585 FollowingMitochondria researcher. Nils-Gรถran Larssonโs group at Karolinska Institutet. #LINO23 ako vam je dobro onda nista. [email protected]
536 Followers 103 FollowingOur mission is to treat patients suffering from primary immunodeficiency diseases with hematopoietic stem cell gene therapy.๐ฉธ๐ฆ โ๏ธ๐งฌโ: tweets from lab members.
3K Followers 746 FollowingSensory neurobiologist & Bioengineer | Racing CX, XC, & Gravel for funsies | Raising money for cancer research through PMC donate before Oct 1 at link below
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$ALA $ALA.ax
1K Followers 478 FollowingDirector, Stem Cell and Gene Therapy @fredhutch. Interested in stem cell biology/transplantation and gene therapy/editing. Immediate Past President @asgctherapy
4K Followers 540 FollowingLead Translator @arenabioworks, formerly Professor of Pathology (on leave, 2023-2025) @HarvardMed, #geneediting, #CRISPR; views expressed are my own
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