Debesh Mandal @debesh
Co-founder and CEO @nanograb (YC S23) London Joined January 2012-
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Debesh Mandal retweeted
The Gene Editing revolution has only just begun. Here is JD Vance describing to Joe Rogan how the first ever approved CRISPR Gene Editing therapy - $VRTX & $CRSP CASGEVY has successfully cured Sickle Cell disease. Today’s FDA approval is another milestone in this revolution! $XBI
1/@VertexPharma have announced today that the FDA has approved expanded use of CASGEVY 🧵👇- $VRTX & $CRSP first-ever approved CRISPR Gene Editing therapy for treating Sickle Cell disease and transfusion-dependent beta thalassemia, for the treatment of people ages 2 years and
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I spent hours doing this in my first job as a barback in a cocktail bar
When a robot hand can pick mint then I will be impressed
Strong believer that interstellar travel will be driven by biological compute combined with biological von Neumann probes
Mycelium Chips? No, not the kind you eat. the kind funded by DARPA that do inference based on the grown structure of mycelium. its a cyborg onramp
Oh yeah lilly is gonna absolutely cook everyone. Didn't novo have a good GLP-1, I forget
love LLY's development of brenipatide: GLP-1 for depression, alcoholism, opioid addiction, bipolar/schiz, smoking and asthma 😂
Pretty sure there is a UK computing grad that exists somewhere who makes £128k in a day
@Grimezsz we can put something together to slow down ovarian fibrosis
em dash here is the best evidence of AGI
@catboosted They are making billions and funding the most important technology arguably of human history — while you are here posting about how you are “puzzled”, hiding behind an anonymous account, replying to other anonymous nobodies (i.e. ME). And yet they are “retarded”?
@ryanstellar pretty sure YC's advice for almost 20 years has been to go and meet your customers in person, especially early on cc Brian Chesky using Airbnb for the first time, Collison Install + many others I'm sure
Increasingly clear that we are about to have a smallpox-vaccination-like moment in healthcare over the next 20 years where one area is completely revolutionised. Seeing comments about consumer, longevity, cancer, emergency, rare disease Could be all of them!
I really hope the moab in moab tx stands for mother of all binders
@paulg AI text has replaced marketing jargon but we'll become immune eventually Yvon Chouinard nuked himself with giardia infested water to then be able to tolerate it on long climbs
Insane amount of alpha if point 2 turns out not to be true
I'd also say most biotechs are not as well run (from what I can tell). And they could learn a lot from the software industry. i.e. techbio > biotech And the 1-2 orders of magnitude complexity will get tackled with AI, not human brains. i.e. bio-naive > bio-insight driven
@owl_posting TradBrits love talking about problems but there is a new generation who want to solve them
Debesh Mandal retweeted
A technical dive inside our new "Midjourney Scanner"
likely only possible with synthetic biology systems heavily involved
Should SpaceX build a von Neumann probe (self replicating spacecraft)? Potentially fastest path to explore the galaxy but without humans. It extends the light of consciousness, just not human consciousness.
peptide origami
Can small peptides have tertiary structures and behave like big proteins? Our preprint showing that peptide frameworks supports tertiary structure in < 20 amino acids. The pores have many mutable residues that cooperatively engage with complex molecules. Link in the comments.:
@EMostaque @SpaceX @cursor_ai Seems weirdly reasonable
Cursor to pivot/expand into biotech and win because Elon knows how to build hardware (and has done it in healthcare with neuralink)
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Amelie Heuer-Jungeman... @Amelie_HJ
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