Dr. Anda Garay @estumed
Internista apasionado por la medicina, ciencia, historia y literatura. Clínico, hospitalista y filósofo de la vida. Distrito Federal, México Joined August 2009-
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✨ #EASD2025 – SURPASS-CVOT En >13,000 pacientes con DM2 + ECV: ✅ MACE-3 HR 0.92 (no inferior a dulaglutida) ✅ HbA1c −1.7% ✅ Peso −12.1% ✅ Mortalidad total ↓16% ✅ Protección renal ⚠️ Más EA GI 👉 Tirzepatida: seguridad CV + beneficio integral. #Diabetes #Cardiovascular
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TIRTLE1 (fase 2, n=24, DM1 + obesidad, 12 sem) 🎯 Tirzepatida 5 mg semanal vs placebo ✅ –10.3kg peso ✅ –0.5%HbA1c ✅ –25%insulina basal ✅ –49%insulina bolo ✅ ↓ var glucosa (MAGE –12.8) ⚠️ Sin EA graves 👉 Potencial adyuvante en DM1 con obesidad. Fase 3 en marcha. #EASD2025
REDEFINE 2 (n=1206, IMC ≥27, DM2 ≥6 meses, HbA1c7–10%) Objetivo: evaluar eficacia/seguridad de CagriSema (semaglutida 2.4 + cagrilintida 2.4 mg) vs placebo en 68 sem. ✅ –15.7% peso ✅ –2.0% HbA1c ✅ ↓ PA, TG, PCR-us; ↑ HDL ⚠️ EA como los más #EASD2025 #InternistasConCiencia
Dr. Anda Garay retweeted
Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS‐CVOT design and baseline characteristics In SURPASS-CVOT, Mounjaro achieved the primary objective by demonstrating a non-inferior rate of major adverse cardiovascular events (MACE-3), including cardiovascular death, heart attack or stroke vs. Trulicity sciencedirect.com/science/articl…
💊 Orfoglipron, 1er GLP-1 oral no peptídico, mostró en #ACHIEVE1 (fase 3): 📉 HbA1c ↓ hasta -1.6% ⚖️ Peso ↓ hasta 7.3 kg 🧪 Perfil de seguridad favorable 📰 Presentado en #ADA2025 y publicado en NEJM #Diabetes #GLP1 #Innovación #internistasconciencia
📊 #ADA2025 | Meta-análisis de 6 RCT:estatinas no aumentan de forma significativa el riesgo de DT2 (RR 1.04, IC 95% 0.92–1.19). 📌 El riesgo solo fue mayor en JUPITER y eran pacs con múltiples factores de riesgo cardio metabólico 🔑 Individualizar en c Pac #InternistasConCiencia
🧠 ¿GLP-1 y salud mental? Metaanálisis presentado en #ADA2025: 🔸 80 estudios 🔹 Sin aumento en eventos psiquiátricos 🔹 Sin cambios en síntomas depresivos 🔹 🆙 Mejoría leve en calidad. #GLP1 #JAMAPsychiatry #InternistasConCiencia #MedicinaInterna #Diabetes #ADA2025
6/ Conclusión El CAC no es solo una imagen. Es una herramienta de medicina personalizada. 👉 Nos obliga a redefinir la prevención primaria. #InternistasConCiencia #PrevenciónCV #ADA2025
5/ Medir CAC cambia conductas 🔻 ↓ LDL-C 🔻 ↓ TA ✅ ↑ uso de estatinas, ASA, adherencia y ejercicio 🧠 La imagen mueve a la acción
🫀 ¿Cuándo el calcio coronario (CAC) cambia todo? En #ADA2025 se recordó por qué el CAC es una herramienta clínica poderosa que reclasifica riesgo y transforma decisiones médicas. 👇🧵
🔴🫀 #ACC2025 nos deja claro: el futuro de la cardiología es 🔬 personalizado, 🤝 multidisciplinario y 📈 guiado por evidencia e innovación. ¡La ciencia avanza al ritmo del paciente! 💡🌍
Lepodisirab RNAi, estudio clínico fase 2, demuestra eficacia y seguridad en disminuir niveles de Lp(a).
ICYMI: The ALPACA trial showed that among patients w/ elevated Lp(a), lepodisiran reduces mean serum concentrations of Lp(a) from 60 to 180 days after administration. Read more ➡️ bit.ly/4j5vpNq #ACC25
Dr. Anda Garay retweeted
ICYMI: The ALPACA trial showed that among patients w/ elevated Lp(a), lepodisiran reduces mean serum concentrations of Lp(a) from 60 to 180 days after administration. Read more ➡️ bit.ly/4j5vpNq #ACC25
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