Gad @gadmark
PhD candidate studying transport mechanisms at Rockefeller University NYC Joined May 2011-
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Gad retweeted
Excited to share our new work! We identified SLC33A1 as the major ER GSSG exporter that maintains redox balance in the ER lumen.
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…
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@nicoledelgaudio @shanshanliu1218 @KivancBirsoy @HiteLabMSKCC Thanks Nicole!
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s4155… 🧵 1/9
Gad retweeted
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…
Gad retweeted
In @NatureCellBio: @KivancBirsoy's lab has discovered that the antioxidant glutathione plays a vital role in maintaining smooth operations of a protein-producing hub in the cell called the endoplasmic reticulum by acting as a protein “proofreader.” 🔗: bit.ly/3Ow8lxM
Gad retweeted
Check out this amazing work by @shanshanliu1218 and @gadmark !
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s4155… 🧵 1/9
Gad retweeted
Check out this impressive work and #tweetorial from @gadmark and @shanshanliu1218! If you’re interested in organellar metabolism and metabolite transport, this is a landmark paper on ER redox metabolism and transport👇
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s4155… 🧵 1/9
@AlonMillet @shanshanliu1218 Thank you Alon! Your proteomics and RNA-seq analysis were a key part of this story. Really appreciate everything you brought to this
Gad retweeted
Was an honor to contribute to this tremendous study co-led by the brilliant duo of @gadmark and @shanshanliu1218. Check out the thread below to learn more about how SLC33A1 works to maintain ER redox balance!
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s4155… 🧵 1/9
@ToshiNakamura51 @shanshanliu1218 @KivancBirsoy @HiteLabMSKCC Thanks Toshi!
Grateful to everyone who made this possible. Thank you to @shanshanliu1218, @KivancBirsoy, @HiteLabMSKCC, and all co-authors. Proud of what we discovered together across @RockefellerUniv and @MSKCancerCenter. 9/9
Loss of SLC33A1 shifts PDIs toward oxidized states, triggers ER stress, and creates dependency on ERAD. Disease variants linked to Huppke-Brendel syndrome impair GSSG export. This work connects ER redox biology to neurodegeneration and cancer. 8/9
Read my latest newsletter on big pharma’s commercials during tonight’s #SuperBowl . And don’t forget to subscribe markgad.beehiiv.com/p/pharma-super…
Gad retweeted
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