Derek Abbott @inflammgenetics

Cecil and Ida Green Chair of Immunology and Genomic Medicine. National Jewish Health. Physician Scientist target hunting in inflammation. Views are my own. Denver CO Joined May 2013

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Derek Abbott @inflammgenetics

6 days ago

@BostonStrong_34 Rockies are not the same level of bad. They are young and the effort is there. The other two are fatally flawed

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Derek Abbott @inflammgenetics

6 days ago

@BostonStrong_34 I was at the game and the choke job Monday night. This team is worse in person. Boring to watch and playing dumb baseball. On their way to their worst season since 1931.

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Pretty interesting story in @ScienceMagazine this week on what looks like a serious problem in the senescence field. More than 400 papers apparently used the wrong antibody for p16-INK4a — an antibody that actually recognizes a completely different, unrelated protein (a component of the actin cytoskeleton). This affects work on senescent cell accumulation in aging and disease, and most critically, some of the evidence base for senolytic drug research. What concerns me most is that many of these papers somehow got the "right" answer using the wrong antibody. That's not just an innocent reagent mix-up — it raises real questions about data fabrication or selective reporting in at least some of these labs. I've commented before about how ignoring data that doesn't fit the narrative is a major problem in certain areas of the longevity literature (e.g. sirtuins and NAD), and here a potentially widespread example in senescence. Hopefully journals will investigate and retract as necessary, but based on my experience that seems optimistic. One concrete fix is that journals should flag problematic antibody product codes at submission so reviewers can catch this before publication. Reviewers should absolutely be on the lookout for this going forward. However, these fixes won't address the larger problem. We need to understand how these scientists got the results they wanted and published them over 400 times (!!!): whether through intentional deception, incompetence, accident, or some legitimate explanation. Credit for discovering this goes to @addictedtoigno1 who wrote about it first on his blog: For Better Science science.org/content/articl…?

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Derek Abbott @inflammgenetics

3 weeks ago

@BallParkBuzz Shane Drohan started today in Denver against the Rockies. Gave up 2 runs in the first due to Brewers atrocious defense - 2nd baseman lost a ball in the sun and CF overran a ball. Should have been 1 earned over 6 1/3 at altitude. He was effficient and looked good.

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Derek Abbott @inflammgenetics

4 weeks ago

@LangmanVince Northeast Ohio has very high taxes. He'll pay 2.5% to Cleveland, 1.5% to Westlake (Rita tax, where he lives), 2.75% to Ohio and then $25K in property taxes. California costs more, but there's a big difference in Ohio taxes in the Cleveland area versus, say, Dayton. He's paying.

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Dr. Catharine Young @DrCatharineY

a month ago

In case you still think there is any normalcy in how scientists are being treated at NIH. Photo credit: 27UNIHTED

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Rep. Jake Auchincloss 🟧 @RepAuchincloss

a month ago

Asked mid-season about the Yankees, former Red Sox General Manager Theo Epstein once said that he had looked at their roster at the start of the season, realized that they'd win 100 games, and now ignored their weekly standings in order to focus on his own roster's ability to compete. I raised this anecdote at a recent roundtable of experts discussing China's rise in biotechnology. China is uplifting scientists, investing hundreds of billions in R&D, and accelerating clinical trials. It's going to win 100 games. The center of biomedical gravity is moving to China from America, just like it moved from Europe to America at the close of last century. Unless America decides to win 110 games. statnews.com/2026/05/18/bio…

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Derek Abbott @inflammgenetics

3 months ago

Drug targeting human MLKL might focus on preventing the release of the 4-Helix bundle rather than preventing MLKL phosphorylation. 4/4

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Derek Abbott @inflammgenetics

3 months ago

MLKL prevents further kinase activity of RIPK3 beyond the initial auto-phosphorylation at sites 224 and 227. In humans, Michelle's work shows that the key initiating event in MLKL activation is not phosphorylation but rather a flipping of the 4-helix bundle of MLKL. 3/4

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Derek Abbott @inflammgenetics

3 months ago

CWRU MSTPstudent Michelle Pan's dissertation is now available online. In this work, Michelle challenged the idea that, in human necroptosis, RIPK3 phosphorylation of MLKL is the main pore-initiating event. 1/3 cell.com/cell-reports/f…

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Derek Abbott @inflammgenetics

4 months ago

@MikeReiss Great stuff as usual, Mike! Any word on Jedrick Wills? His knee injury might have been mismanaged by the Browns. They tried to convert him from right tackle to left tackle, where he was serviceable, if not more than average. Thoughts on him being a Morgan Moses backup?

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Derek Abbott @inflammgenetics

4 months ago

Excited for ⁦@cwrumstp⁩ and new Abbott lab alum, Michelle Pan, to defend her dissertation today! Congratulations to Dr Pan. Look out for her paper coming out in a couple of weeks!

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Derek Abbott @inflammgenetics

4 months ago

This weekend, my wife and I were very excited to attend our first Beaux Arts Ball at National Jewish Health. Its very inspiring to work at an institution dedicated to finding treatments and cures for immunologic diseases and to work with such a dedicated team. @KathrynTeng

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Derek Abbott @inflammgenetics

4 months ago

@MaroonBlackPuck Kathryn and I are following from Denver. LETS ROLL US!!!!

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Derek Abbott @inflammgenetics

4 months ago

@SavageSports_ He used to be very good, but the Browns benched him late in the season. Given the state of their OLine, he might be done.

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Derek Abbott @inflammgenetics

5 months ago

Pleased to share a new review article focusing on Gasdermin D's role in Pathology spearheaded by Bowen Zhou, a former @cwrumstp student and current Pathology fellow @UHhospitals annualreviews.org/content/journa…

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Derek Abbott @inflammgenetics

5 months ago

@BishopBarron We pay >$95K a year for my son to attend Dartmouth. Let's see her start with Point #1 first.

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Derek Abbott @inflammgenetics

5 months ago

@JohnStreicher1 @drugmonkeyblog I think I may put PMCIDs in the body of the text describing contributions to science? Without any references, you could just say anything (ie after I completed my career as a top gun fighter pilot and piloted the space shuttle into orbit, I turned my attention to science).