Derek Abbott @inflammgenetics
Cecil and Ida Green Chair of Immunology and Genomic Medicine. National Jewish Health. Physician Scientist target hunting in inflammation. Views are my own. Denver CO Joined May 2013-
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@BostonStrong_34 Rockies are not the same level of bad. They are young and the effort is there. The other two are fatally flawed
@BostonStrong_34 I was at the game and the choke job Monday night. This team is worse in person. Boring to watch and playing dumb baseball. On their way to their worst season since 1931.
Pretty interesting story in @ScienceMagazine this week on what looks like a serious problem in the senescence field. More than 400 papers apparently used the wrong antibody for p16-INK4a — an antibody that actually recognizes a completely different, unrelated protein (a component of the actin cytoskeleton). This affects work on senescent cell accumulation in aging and disease, and most critically, some of the evidence base for senolytic drug research. What concerns me most is that many of these papers somehow got the "right" answer using the wrong antibody. That's not just an innocent reagent mix-up — it raises real questions about data fabrication or selective reporting in at least some of these labs. I've commented before about how ignoring data that doesn't fit the narrative is a major problem in certain areas of the longevity literature (e.g. sirtuins and NAD), and here a potentially widespread example in senescence. Hopefully journals will investigate and retract as necessary, but based on my experience that seems optimistic. One concrete fix is that journals should flag problematic antibody product codes at submission so reviewers can catch this before publication. Reviewers should absolutely be on the lookout for this going forward. However, these fixes won't address the larger problem. We need to understand how these scientists got the results they wanted and published them over 400 times (!!!): whether through intentional deception, incompetence, accident, or some legitimate explanation. Credit for discovering this goes to @addictedtoigno1 who wrote about it first on his blog: For Better Science science.org/content/articl…?
@BallParkBuzz Shane Drohan started today in Denver against the Rockies. Gave up 2 runs in the first due to Brewers atrocious defense - 2nd baseman lost a ball in the sun and CF overran a ball. Should have been 1 earned over 6 1/3 at altitude. He was effficient and looked good.
@LangmanVince Northeast Ohio has very high taxes. He'll pay 2.5% to Cleveland, 1.5% to Westlake (Rita tax, where he lives), 2.75% to Ohio and then $25K in property taxes. California costs more, but there's a big difference in Ohio taxes in the Cleveland area versus, say, Dayton. He's paying.
In case you still think there is any normalcy in how scientists are being treated at NIH. Photo credit: 27UNIHTED
Asked mid-season about the Yankees, former Red Sox General Manager Theo Epstein once said that he had looked at their roster at the start of the season, realized that they'd win 100 games, and now ignored their weekly standings in order to focus on his own roster's ability to compete. I raised this anecdote at a recent roundtable of experts discussing China's rise in biotechnology. China is uplifting scientists, investing hundreds of billions in R&D, and accelerating clinical trials. It's going to win 100 games. The center of biomedical gravity is moving to China from America, just like it moved from Europe to America at the close of last century. Unless America decides to win 110 games. statnews.com/2026/05/18/bio…
Drug targeting human MLKL might focus on preventing the release of the 4-Helix bundle rather than preventing MLKL phosphorylation. 4/4
MLKL prevents further kinase activity of RIPK3 beyond the initial auto-phosphorylation at sites 224 and 227. In humans, Michelle's work shows that the key initiating event in MLKL activation is not phosphorylation but rather a flipping of the 4-helix bundle of MLKL. 3/4
CWRU MSTPstudent Michelle Pan's dissertation is now available online. In this work, Michelle challenged the idea that, in human necroptosis, RIPK3 phosphorylation of MLKL is the main pore-initiating event. 1/3 cell.com/cell-reports/f…
@MikeReiss Great stuff as usual, Mike! Any word on Jedrick Wills? His knee injury might have been mismanaged by the Browns. They tried to convert him from right tackle to left tackle, where he was serviceable, if not more than average. Thoughts on him being a Morgan Moses backup?
Excited for @cwrumstp and new Abbott lab alum, Michelle Pan, to defend her dissertation today! Congratulations to Dr Pan. Look out for her paper coming out in a couple of weeks!
This weekend, my wife and I were very excited to attend our first Beaux Arts Ball at National Jewish Health. Its very inspiring to work at an institution dedicated to finding treatments and cures for immunologic diseases and to work with such a dedicated team. @KathrynTeng
@MaroonBlackPuck Kathryn and I are following from Denver. LETS ROLL US!!!!
@SavageSports_ He used to be very good, but the Browns benched him late in the season. Given the state of their OLine, he might be done.
Pleased to share a new review article focusing on Gasdermin D's role in Pathology spearheaded by Bowen Zhou, a former @cwrumstp student and current Pathology fellow @UHhospitals annualreviews.org/content/journa…
@BishopBarron We pay >$95K a year for my son to attend Dartmouth. Let's see her start with Point #1 first.
@JohnStreicher1 @drugmonkeyblog I think I may put PMCIDs in the body of the text describing contributions to science? Without any references, you could just say anything (ie after I completed my career as a top gun fighter pilot and piloted the space shuttle into orbit, I turned my attention to science).
Is the consensus on the new online NIH Biosketch that we cannot list manuscripts in the "Contributions to Science" section? @drugmonkeyblog
Justin Lathia, PhD �... @JustinLathia
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Case Comp Cancer Ctr @caseccc
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James Morrow @jamesjmorrow1
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PhilipAhern @PhilipAhern
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Jake Scott @CancerConnector
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UH Research & Educati... @UH_RE_Institute
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MSTP at Case Western ... @cwrumstp
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Michael F. Cannon �... @mfcannon
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NK Escareño @NKcellMX
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Laurence Kohler @LaurenceKo13881
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Upasana DasAdhikari @UpasanaDA
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Kautilya Kumar Jena @kjena21
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73 Followers 202 Following Graduated from Mahidol https://t.co/i2jeICdyJo the world 💃 Embrace new cultures. ✨✨ Make every moment count. 🌸🌸
Jeehyun Karen You @JKarenYou
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189 Followers 743 Following 🌸 Living life on my terms. 💖 Confidence is my superpower. ...
Rebecca @rebecca_36a
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34 Followers 313 Following Copywriter| Email Marketer| Business Strategist. Helping Entrepreneurs like you in different countries build a 6-figure internet business.
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417 Followers 1K Following If we don’t understand people, we don’t understand business.🤗
Puja Kumari @dolly_puja
110 Followers 216 Following Assistant Professor| Binghamton University | State University of New York (SUNY) | Immunology | Former Postdoc in Vijay Rathinam Lab, UConn Health
Francis Chan @FrancisKChan93
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Cleveland IDEAS @CLE_IDEAS
34 Followers 50 Following Cleveland IDEAS (International Digestive Education and Science)
Qihua "Kimmy" Ye @QihuaKimmyYe
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Kole DeGolier @KoleDeGolier
120 Followers 388 Following Immunology PhD Candidate • University of Colorado • Lab of Terry Fry, MD • Working to improve engineered cellular therapies for pediatric cancers.
Kai Li @Kai_Li_IDImmune
135 Followers 474 Following Assistant professor of immunology, UConn Health School of Medicine.
Rune Busk Damgaard @rbdamgaard
2K Followers 1K Following Associate Professor, Section for Medical Biotechnology, Technical University of Denmark. Studies ubiquitin signalling in inflammation, metabolism, and disease.
Caroline Armstrong @Corneli67918875
862 Followers 140 Following Like traveling | cycling | fitness | investors |share interesting topics| robotsand scammers please stay away from
Erin Getty @eringetty98
762 Followers 2K Following @aratac_hockey sponsored/Microbiology Graduate/MSc Experimental Medicine/PhD from @WWIEM_QUB w/ @UltanPower & @Rebecca_Coll/Postdoc @tcddublin #ATID
Janhavee Shinde @SJanhavee
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Adeel Mirza @2001_adeel
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Justin Lathia, PhD �... @JustinLathia
8K Followers 2K Following Lab studying cancer from a stem cell and cell-cell interaction perspective, #cancerstemcells, #glioblastoma, #GBM. Tweets are my own. @DrexelUniv @NIHOxCam alum
Paul Tesar @TesarLab
2K Followers 1K Following GirlDad | Professor @CWRUSOM developing glial therapies for neuro diseases | DPhil @UniofOxford @NIHOxCam | Co-founder @convelotx | Director @riseupneo | Foodie
Prof. Hao Wu @WuLabHarvard
6K Followers 164 Following Asa and Patricia Springer Professor of Structural Biology @ Harvard Medical School and Boston Children’s Hospital. #immunology #structure_biology
Kevin Allan @kevbot1992
439 Followers 562 Following MD/PhD, Ophthalmology resident @ClevelandClinic. Studies stem cells for disease modeling and drug discovery. @tesarlab @cwru he/him/his | 🏳️🌈🔬
David Sweet, MD PhD @davidr_sweet
301 Followers 506 Following Clinical Pharmacology Physician with @KrystalBiotech; Training through @PittGIM @cwrumstp @ohiostate ; He/Him
Bryan Carmody @jbcarmody
55K Followers 891 Following The Sheriff of Sodium | Pediatric nephrologist | Associate professor | APD | Husband | Dad | Virginian | Advocate for medical students and common sense
Ruth Keri @RuthKeri2
959 Followers 504 Following Dept. Cancer Biology @CCLRI @ClevelandClinic Professor Mol Med. @CWRUSOM. Associate Director for Basic Research @caseccc; #breastcancer researcher; #FGLI #bcsm
Jonathan Kagan @jkagan1
8K Followers 83 Following Scientist at Boston Children's Hospital, Professor of Pediatrics at Harvard Medical School, Husband, Father.
James Morrow @jamesjmorrow1
467 Followers 561 Following MD/PhD Pediatric Hematology/Oncology Physician-Scientist Dana-Farber. Post-Doc Bernstein Lab DFCI/Broad.
Harmit S. Malik @HarmitMalik
43K Followers 7K Following Study genetic conflicts professionally. Try to avoid conflicts in personal life (with mixed results). @HutchBasicSci @fredhutch @HHMINEWS He/him
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73K Followers 13K Following I science & try to make science open. Tweets do not represent my employer's views, but are always correct. My conflicts of interest https://t.co/77P0LDe6VR.
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MSTP at Case Western ... @cwrumstp
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Charlie Evavold, find... @Synth_Immune
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Mark Daniels @ByMarkDaniels
64K Followers 787 Following Patriots coverage for MassLive. Past: Providence Journal & Boston Herald. UNH alum. Proud husband and father. Come for the binocular pics, stay for the stories.
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The Jefferson Council @TheJeffersonC
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147K Followers 306 Following CEO of Reventure App. Check our mobile app for price forecasts in your ZIP code.
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790 Followers 525 Following Evolutionary immunology, Host-pathogen interactions , PI at @WeizmannScience
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2K Followers 1K Following Associate Professor, Section for Medical Biotechnology, Technical University of Denmark. Studies ubiquitin signalling in inflammation, metabolism, and disease.
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4K Followers 1K Following The leading respiratory hospital in the nation. A nonprofit tweeting about the latest treatment & research for respiratory, cardiac, immune & related conditions
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9K Followers 25 Following Healer, science nerd, the real has risen. But just you wait. Just you wait. Views reflect accumulated biases...they really do.
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Marissa Locke Rotting... @locke_marissa
589 Followers 1K Following Editorial Content Manager @ASBMB; @WUSTL @WUSTLImmuno @depaulU alumna; https://t.co/svZ0zRoVjN
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1.5M Followers 525 Following Senior writer, @TheAthletic; @MLBonFOX field reporter; Insider, @FoulTerritoryTV. Height: 5-4 1/2
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