narf42 @narf42

Associate Professor for Molecular Evolution @univgroningen ; passionate scientist and insomniac. News, views & random things mayerlab.nl/index.html Groningen, Nederland Joined June 2014

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narf42 @narf42

3 weeks ago

A huge congratulations to @Titi_a93 for this outstanding Review! 👏 She did an exceptional job navigating a rapidly growing field, compiling the literature, and providing a thoughtful, critical, and forward-looking perspective on where hybrid peptide discovery is heading.

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narf42 @narf42

3 weeks ago

We discuss: 🔹 cysteine- and lysine-targeting cyclization strategies 🔹 residue-selective and chemoenzymatic approaches 🔹 proximity-driven chemical transformations 🔹 exploiting the chemical robustness of bacteriophages (4/5)

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narf42 @narf42

3 weeks ago

🧵 New review out in Chemistry – A European Journal! Hybrid macrocyclic peptides: combining biological selection with synthetic chemistry to discover next-generation therapeutics. Why are hybrid macrocyclic peptides so exciting? 👇 (1/5) …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…

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narf42 @narf42

8 months ago

📢 📢 📢 !!!Come and join us!! 📢 📢 📢 We are looking for a Postdoctoral Researcher with in-depth experience in next- and third-generation sequencing to help us understand the fitness landscapes of complex biomolecules! Please spread the word :) werkenbij.rug.nl/vacature/postd…

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narf42 @narf42

a year ago

Overall, our study presents the first large-scale engineering campaign of FAcDs and introduces an operationally simple selection platform that paves the way toward adapting these enzymes for the sustainable degradation of contaminating organofluorides. (5/5)

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narf42 @narf42

a year ago

Forcing populations of bacteria expressing tens of thousands of distinct FAcD-variants to utilize various organofluorides as sole carbon source, we elicited a panel of FAcD variants with improved activities and drastically altered substrate profiles. (4/5)

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narf42 @narf42

a year ago

With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzanne__jansen, who has outdone herself in this project! (1/5) biorxiv.org/content/10.110…

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Maximilian Gantz @MaxGantz_

a year ago

So glad to see this out! By giving a strong fluorescence signal to read out NAD(P)H concentration, SAFRAN will greatly extend the range of reactivities comfortably assayable in droplets. This will make droplet microfluidics a much more versatile tool for biocatalyst engineering!

J. Am. Chem. Soc. @J_A_C_S

a year ago

Fluorogenic, Subsingle-Turnover Monitoring of Enzymatic Reactions Involving NAD(P)H: a Generalized Platform for Directed Ultrahigh-Throughput Evolution of Biocatalysts in Microdroplets | JACS @hollfelderlab @Cam_Biochem @Cambridge_Uni pubs.acs.org/doi/10.1021/ja…

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narf42 @narf42

a year ago

Two weeks ago, we had a great group outing, including a city tour through Utrecht, a Mario Kart Wii tournament, and some Rock Band Wii fun! I am truly privileged to work with such a group of talented, dedicated, and smart individuals.

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Francesca Grisoni @fra_grisoni

a year ago

🚨Open PhD positions @TUeindhoven & @univgroningen! Are you intrigued by the potential of ML+directed evolution in drug discovery (@fra_grisoni), peptide catalysis (@robpollice) or biocatalysis (@narf42)? Do you like interdisciplinary, cutting-edge research? Then apply!👇

narf42 @narf42

a year ago

📢📢📢The ML-GUIDE team (@fra_grisoni, @robpollice and myself) are looking for 3 PhD students, passionate about combining the directed evolution of diverse biomolecules with deep learning approaches to develop better (bio)catalysts and drugs! Pls retweet tinyurl.com/3jz97ter

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narf42 @narf42

a year ago

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Francesca Grisoni @fra_grisoni

2 years ago

Finally, officially open! Open #postdoc position in Organic/Medicinal Chemistry for generative #AI in Drug Discovery — join us @molecularML @TUeindhoven 💪🏻 Funded by @ERC_Research Deadline: Jan 15, 25 More info below👇 jobs.tue.nl/nl/vacature/po… Repost appreciated! 🔃

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Francesca Grisoni @fra_grisoni

2 years ago

Great news to conclude 2024! I couldn’t think of a better team than the ones and only @narf42 and @robpollice to work on this exciting project. 🚀 Cool times ahead for the collaboration between @TUeindhoven and @univgroningen!

narf42 @narf42

2 years ago

🥳🥳🥳 Early Christmas Present for @fra_grisoni @robpollice and me! @NWOFunding awarded us €2.7 million for our NWO-XL grant "ML-GUIDE – Machine Learning-GUIded Directed Evolution for drug discovery and (bio)catalyst engineering"! Best! Consortium! Ever! nwo.nl/en/news/64-mil…

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narf42 @narf42

2 years ago

Over the past 18 months, we spent A LOT of time planning, discussing, writing, fine-tuning, and WAITING. I had such a blast though and couldn't have wished for a more creative, critical (!), and dedicated team! Thrilled beyond belief that all our efforts paid off!