Francis Wong @packeted
Physician, Berkeley MBA/MPH, Stanford Biodesign Fellow, co-founder & CEO @auricleneuro (YC W21) working on a next generation cochlear implant franciswong.com Oakland, California Joined June 2009-
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@claudeai's new Claude Science app just answered a question I'd asked several bioinformaticians for help with, with no luck. Our son carries a rare de novo point mutation, and I wanted to know if it came from mom or dad. Claude Science ran a read-backed phasing analysis on our trio WGS data: it found a SNP 301bp away with good coverage, homozygous in mom and heterozygous in dad. The same reads carrying his de novo variant also carried the heterozygous allele at that SNP - question answered. This is going to speed up workflows tremendously for people doing real science and it's just getting started!
@daiviksiddhi Awesome work @daiviksiddhi - this is going to be a incredibly useful tool for so many people!
@deenamousa I don't doubt it will eventually happen but outside of specifically trained models which can be incredibly useful, we still have a long way to go as GPT-5 showed me today
@elonmusk @neuralink This is what we're trying to do at @auricleneuro with a little help from @jesslivingston @paulg and @ycombinator. We've got a fundamentally different approach to Neuralink but would love to help in your mission!
@t_blom I've been waiting for this since they launched chatgpt voice... If you make it happen and I promise to eat your dog food on my commute to MTV! :)
Implantable BCI company? Not for the faint hearted. It’s ~ 15+ years. Control your burn if early. You can’t spend to accelerate safety. (Below, “clinical” means fully implantable technology stack and company sponsored trial) Assumptions based on class 3 PMA stories and looking at market leader histories. Where are my assumptions wrong? Synchron 8 years preclinical: 2011-2019 6 years so far clinical: 2019- 2028 target approval date for PMA Neuralink 8 years preclinical: 2016-2024 1 year clinical: 2024- ? target approval date (is it 2032?) Paradromics 10 years preclinical: 2015- Not yet clinical ? target approval date (is it 2033?) Precision 4 years preclinical: 2021- Not yet clinical ? target approval date (is it 2037?) Echo 2 years preclinical: 2023- Not yet clinical ? target approval date (is it 2039?) BlackRock Neuro Not sure here - they have a long history of clinical trials but without fully implantable system. Now well funded and kicking off effort to develop a commercial tech stack, so let’s start from Tether funding but presume their preclinical phase is brief… Preclinical: 2024- Not yet clinical ? target approval date (is it 2039?)
No one understands the challenges of raising a family in Oakland more than my wife, Erica. As a mother, she feels the weight of the crime, the trash, and the fear that so many parents in our city carry every single day. This isn’t just political for us, it’s deeply personal. Erica’s voice reminds me, every day, why I’m in this fight: to build an Oakland where no parent has to pray their child makes it home safely.
@larsmoravy WiFi hotspot mode, middle front seat in the cybertruck, starlink connectivity.
Pizza Ponte is the best! Temescal is just down the road from us with so many great spots, but alas, we rarely go beside for food pickup (+ dropping off my ballot) as we worry about car windows getting smashed. I've seen people breaking into cars in broad daylight and the broken glass is usually strewn along Pay & Display. Arco always has people loitering around when you fill up. Golden Gate Donuts, another decades-old family-run classic, has been raided at least a couple times in recent memory. So much room for improvement and I think your plan will help get us there!
@MattMahanSJ This is a very meaningful endorsement and thanks for your support for Oakland @MattMahanSJ - love what you're doing for San Jose!
@linamkhan @PatRyanUC Thanks for highlighting this important work! Similar effects are being seen in the veterinary care business which is rapidly consolidating yet relative to human health care is virtually unregulated with almost no liability when things go wrong.
9. Of course, winning this race will just be the start of a long and arduous journey but I think @lorenmtaylor is up to the task - Oakland's future might depend on it. What do you think?
8. I didn't know who Barbara Lee was before the race and while I respect her past accomplishments and drive it's time to pass the baton to the next generation. Gerontocracy is not a winning strategy
My ballot for the Oakland mayor special election arrived last week. We've invested our family's future in this great city but we're at a critical juncture. I'm voting for @lorenmtaylor and here's why 🧵...
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