Kari Hoffman @perpl_lab
PI at Vanderbilt University. See @[email protected] perpllab.psy.vanderbilt.edu Nashville, TN Joined March 2015-
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Kari Hoffman retweeted
Multi-Neuromodulatory fingerprints of an adaptive cognitive state: Cognitive engagement was predicted by joint GABA & ACh/Choline in PFC; by Dopamine & Cholinergic changes in striatum. Glutamate & ACh correlated across states. Kudos to team + Dr Pawliszyn biorxiv.org/content/10.648…
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Kari Hoffman retweeted
2/2 Abilities of inhibitory control, WM updating, and shifting distinguished cognitive phenotypes in NHP's; expl. factor analysis suggested 1) WM updating 2) Shifting/Learning, and 3+4) inhibitory control of interference from external vs internal sources are 4 sep. cogn. factors.
Kari Hoffman retweeted
New paper shows causal effects of gaze-contingent stimulation on learning feature-based attention: Treuting et al. (2025) Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum. Neuron cell.com/neuron/fulltex… 1/2
Kari Hoffman retweeted
Experience reorganizes content-specific memory traces in macaques 🐒🧠. @perpl_lab @AymanAljishi tinyurl.com/Perpllab-react
Kari Hoffman retweeted
🌟 Cai Lab @Nature paper alert! In new work led by @mysteriousjoe_, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/9) Read it here: nature.com/articles/s4158…
Kari Hoffman retweeted
I am and have been fascinated with how memories are formed and stored. A big challenge, not unique to memory, is synthesizing concepts across scales of anaylsis - from molecules to computation. Here I try to distill how we can move forward in understanding memories. Thanks /1
Jason Shepherd @JasonSynaptic asks eight scientists to weigh in on what makes memories last—dynamic ensembles or static synapses? thetransmitter.org/the-big-pictur…
@Timothy0Leary “Silent” residual Ca++ and WM. Counterintuitive to some, and still not fully embraced in chunks of the literature: science.org/doi/10.1126/sc…
What makes memories last—dynamic ensembles or static synapses? | The Transmitter: Neuroscience News and… disq.us/t/4r3afea Thanks to @JasonSynaptic for organizing!
Come to U10 U11 this morning if you’re interested in NHP cell assemblies, memory replay, wireless recording 100s of units during learning of new and old context-specific sequences, all in freely moving (and sleeping) monkeys #sfn2024
@Neurocircuits @MillerLabMIT Oh, the intrigue, right?
Kari Hoffman retweeted
The best event of #SFN2024 or maybe ever. ticketweb.com/event/pavlovs-…
Kari Hoffman retweeted
New research from @perpl_lab sheds light on the circuit organization that supports memory and spatial cognition. 🧠 This discovery helps with our understanding of how our brains process complex cognitive tasks. 🔗 Read the full study here 👉 cell.com/cell-reports/f…
Kari Hoffman retweeted
New Paper in @CurrentBiology! Chimpanzees across FIVE communities take rapid turns in gesture-to-gesture exchanges resembling human conversational patterns. Language may not be a pre-requisite for fast-paced, coordinated communication in social species sciencedirect.com/science/articl…
Kari Hoffman retweeted
Women are consistently under-cited in neuroscience. @anne_churchlandand and @FDavatolhagh share tools that can help assess citation diversity. thetransmitter.org/publishing/wom…
@Isotope56 @NeuroPolarbear @NatureComms @MorenoBote Nice to see this out! @Brad_Buchsbaum
Kari Hoffman retweeted
Cortical interneurons learn on the job! Speculated this was true a decade ago! @JJSherryWU and @artofbiology finally provide evidence! biorxiv.org/content/10.110…
@GeorgeDragoi2 @markbrandonlab @NatureNeuro @YalePsych @YaleNeuro @WuTsaiYale @YaleMed @kefei_6 This looks amazing - congratulations!
Kari Hoffman retweeted
Monumental new work from the @GeorgeDragoi2 lab tackles the question of how replay can parallelize, bind, and compress representations of 15 (!) unique linear track experiences: nature.com/articles/s4159…
@dunmao_ @SAbbaspoor @CellReports @DiagBiochips You bet - shoot me an email and we can chat!
📢The latest from talented @SAbbaspoor 's PhD is out in @cellreports! You into ensembles (@DiagBiochips DA or #neuropixels in #nhp)? ❤️CA1 microcircuits? Wonder why we don’t know how they support #memory or behavior in #primates? Like inhibitory cell types? Cell Assemblies in😴?
Excited to share that the latest @perpl_lab paper is published in @CellReports. We describe the dynamics of superficial and deep CA1 pyramidal cells and identified putative groups of inhibitory cells in freely moving, thinking, and sleeping macaques. 1/n
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