Ryan Potts @pottslab
VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father Thousand Oaks, CA Joined January 2014-
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Ryan Potts retweeted
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
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Apply now to Amgen’s postbacc program! #mycompany
Ryan Potts retweeted
What if a small molecule could activate a transcription factor program in one cell type and destroy the same pathway in another? In our new preprint, we describe one such story on bifunctional molecules that toggle between transactivation and repression.
Ryan Potts retweeted
Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules biorxiv.org/content/10.648… #biorxiv_biochem
Ryan Potts retweeted
Functional inactivation of the telomerase chaperone TCAB1 primes cells for the activation of ALT in osteosarcoma biorxiv.org/content/10.648… #biorxiv_cancer
Ryan Potts retweeted
Selinexor is an allosteric degrader: it stabilizes XPO1/CRM1 to expose a cryptic ASB8 E3 ligase site, triggering ubiquitination. Led by Casey Wing, Joyce Fung & Bert Kwanten. #TargetedDegradation #Allostery nature.com/articles/s4158…
Ryan Potts retweeted
Mapping the latent CRBN-molecular glue degrader interactome biorxiv.org/content/10.648… #biorxiv_molbio
Ryan Potts retweeted
Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency biorxiv.org/content/10.110… #biorxiv_molbio
Ryan Potts retweeted
Thrilled to share that I have joined @Amgen as the inaugural Amgen Science Fellow. I look forward to partnering with colleagues to design next-gen therapeutic by integrating AI/ML with high throughput synthetic biology platforms. linkedin.com/posts/drhoward…
Ryan Potts retweeted
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of @MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be.
Ryan Potts retweeted
Thrilled to share our work to find natural products that inhibit β-catenin! This is the result of an amazing collaboration with @theNCI Natural Products Branch and shows the power of 'up' assays to find new and interesting molecules! biorxiv.org/content/10.110…
Ryan Potts retweeted
A new #ScienceReview looks at a different approach to drug discovery that may enable drugging of unconventional targets through stabilization of macromolecular complexes with molecules known as “LOCKTACs.” Learn more: scim.ag/4lAiKmF
Ryan Potts retweeted
Great to see our two in-house developed kinetic stabilizers, Tolcapone and PITB, against transthyretin amyloidoses cited as examples of an emerging therapeutic class: LOCKTACS. science.org/doi/10.1126/sc…
Ryan Potts retweeted
Talking of @amgen they also have cool LYMTACs: chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization & degradation nature.com/articles/s4146…
Ryan Potts retweeted
Degradation without E3s? Cool approach here - molecules that drag membrane proteins into lysosomes for degradation Might help get around KRASi resistance
🚨New @biorxivpreprint from the @Amgen Induced Proximity group. Here we introduce LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation. 🧵 biorxiv.org/content/10.110…
What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. science.org/doi/10.1126/sc… #mycompnay
@potthofflab @ScienceMagazine Thanks Matt.
Ryan Potts retweeted
Amgen’s LOCKTAC molecular glues are changing how we target disease. 🔬 AMG 193, now in clinical trials, is designed to lock PRMT5 to MTA in MTAP-deleted tumors. Read more about how Amgen is working to innovate in this space.
Check out how we repurpose lysosomal membrane proteins for targeted protein relocalization and degradation using LYMTAC molecules. Now published in @NatureComms. Congrats to @nalawansha and team! #mycompany nature.com/articles/s4146…
🚨New @biorxivpreprint from the @Amgen Induced Proximity group. Here we introduce LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation. 🧵 biorxiv.org/content/10.110…
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