RR @rprane

Crazy take from Claude

“Psilocybin, the psychedelic component of magic mushrooms, has previously been touted as an effective treatment for depression, anxiety, addiction, and PTSD — but now researchers say it has the potential to be used in Alzheimer’s intervention as well. In this case study, published in Frontiers in Neuroscience, researchers focused on an 80-year-old Japanese American woman with Alzheimer’s. She had declined over the previous decade and was reduced to urinary incontinence, speaking in single syllables, and dependence on caregivers for mobility support and daily living. She was then given a 5g dose of magic mushrooms. During the initial phase, she was agitated, sweated profusely and entered a prolonged sleep state that suggested unconsciousness. But around hour 19, she began speaking in full autobiographical sentences, recalling life events she had been unable to articulate for years. In the days and weeks that followed, more incredible changes emerged. She regained urinary continence, even in the evenings, and began dressing herself. She was able to make and maintain eye contact, remember social interactions, emotionally respond to others, and hold lucid conversations.”

Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived #ASCO26

Where will AI be in 1, 2 or 3 years?

you need to be delusionally optimistic negative thinking poisons your brain and leads to congitive decline whereas positive thinking, and gaslighting yourself into thinking everything is amazing, ACTUALLY makes your life amazing too. you must be a silly goose

you can outsource your thinking but you cannot outsource your understanding

Two Anthropic engineers spent 24 minutes exposing every Claude Code feature you didn't know existed. Most people will scroll past this. Don't be most people.

Worth a read! 😍 My mom wanted to send me homemade pickles. But I said ‘no’. I was 27, living in New York, working on Wall Street. I didn't need pickles shipped across the world. The shipping would cost more than buying them here. Three years later, I read the psychologist take on what I'd actually done. When you reject someone's offer to help, you're not just declining assistance. You're declining their need to matter to you! Benjamin Franklin figured this out in 1736. He had a rival in the Pennsylvania legislature who hated him. Instead of trying to win him over with favors, Franklin asked the rival to lend him a rare book. The rival agreed. They became lifelong friends. It's called the Ben Franklin effect.When people do something for you, they convince themselves they must like you. Otherwise, why would they help? My mom didn't want to send pickles because I needed them. She wanted to send them because SHE needed to feel useful to me. To feel like despite the ocean between us, she still had a role in my life. Every time I said "I'll manage," I was taking that away from her. Here's what I learned after a decade of living away from home: → Accepting small favors isn't about you needing help. It's about letting people you love feel needed. Your dad wants to transfer ₹5000 even though you earn well? Let him. Your friend wants to pick you up from the airport even though Uber exists? Say yes. Your partner wants to make you tea even though you can make it yourself? Accept it. The people who love you don't want to solve your big problems. They want to matter in your small moments. Let them. #lifelesson

This paragraph by Richard Feynman hits so hard: “Fall in love with some activity, and do it! Nobody ever figures out what life is all about, and it doesn’t matter. Explore the world. Nearly everything is really interesting if you go into it deeply enough. Work as hard and as much as you want to on the things you like to do the best. Don’t think about what you want to be, but what you want to do. Keep up some kind of a minimum with other things so that society doesn’t stop you from doing anything at all.”

Yoga decreases cortisol. Walking decreases cortisol. Hugging decreases cortisol. Laughing decreases cortisol. Gratitude decreases cortisol. Journaling decreases cortisol. Being kind decreases cortisol. Meditating decreases cortisol. Time in nature decreases cortisol. Helping others decreases cortisol. Slow breathing decreases cortisol. Getting sunlight decreases cortisol. Listening to music decreases cortisol. Limiting phone use decreases cortisol. Petting your dog/cat decreases cortisol. Getting enough sleep decreases cortisol.

Your brain doesn't age because of time. It ages because of repetition. The more predictable your days become, the faster your neurons quiet down. Your brain builds neural pathways based on experience. New experiences create new connections. Repetition strengthens old ones. But when you repeat the same patterns for years, your brain stops building. That's why time feels faster as you age. Your brain stops encoding new memories. It just references old ones. A year at 40 feels shorter than a year at 10, because at 10, everything was new. At 40, everything is familiar. But neuroplasticity doesn't stop. You can still grow new neurons. You can still learn. You can still change. You just have to break the loop. Your brain will wake up. And time will slow down again.

✧ @cessonmute

6 months ago

hit me with the harshest reality truth

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Mentally healthy people are often delusionally optimistic.

DAN KOE @thedankoe

3 months ago

If you want a rare life, you have to be delusional. Doubt can enter your mind, and it can sound reasonable, but if you entertain it too much it will slowly drag you down into stagnation. I'd rather reap the lesson from massive failure than do nothing because it's not "realistic."

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This essay by @alexolegimas is the best thing I've ever read on why AGI won't lead to mass unemployment. A compelling argument backed up by substantial empirical data.

This 2-hour Andrej Karpathy lecture will teach you how to build a Neural Network from scratch better than most engineers at top AI companies will ever bother to learn No frameworks. No libraries. Just pure code and math The same guy who built Tesla's Autopilot AI and co-founded OpenAI recorded this for FREE on YouTube Bookmark & give 2 hours, no matter what. It'll be the most productive thing you do this week

vixhaℓ @TheVixhal

3 months ago

x.com/i/article/2044…

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This 30-minute speech by the Head of Anthropic "Coding Agents" researcher will teach you more about vibe coding than 100 paid courses. Bookmark it & give it 30 minutes today. This video will change the way you use AI forever,

Movez @0xMovez

3 months ago

This weather bot turned $300 → $122K on Polymarket weather markets in 3 months I fully decoded algo and built a self-learning Hermes weather trading agent using weather APIs + Opus 4.7, the bot runs 5-min scans & searches mispricings on Polymarket run your agent in 5 steps:

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Claude Design is insane. ❤️‍🔥Just recorded a 18-min tutorial on how to build animated, award-winning websites with Claude Design + Opus 4.7!

every time you replace “this is hard” with “what’s the first step?” you shift brain activity from your amygdala (fear) to your prefrontal cortex (problem-solving). that’s neuroplasticity in real time.

For all Curious @fascinatingonX

3 months ago

🚨BREAKING: Science confirms that brain cells are influenced by our self-talk.

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