Paul Bevens 🗳😷🧘 @upchange

Microvascular Erasure in Long COVID and Spike Protein Exposure: Complementary Mechanisms of Direct Cellular Injury and Perfusion Impairment Driving Capillary Rarefaction 🚨Spike protein may be erasing your capillaries. New proposal claims LongC0VID’s core problem is irreversible microvascular destruction, not just inflammation. →Structural + functional rarefaction up to 18 months post-inf! ➡️Interesting international evidence-based hypothesis model, a research proposal builds on existing science/literature! ➡️Bear with me…. their hypothesis: 1. Persistent capillary rarefaction is a core hallmark of LongC0VID, detectable up to 18 months post-infection, with studies showing ~45% loss of the smallest capillaries and reduced microvascular health scores. 2. They propose two complementary, interacting mechanisms of “microvascular erasure” driven by SARSCoV2 spike protein exposure: A. STRUCTURAL rarefaction (irreversible physical vessel loss) via direct endothelial and pericyte injury: calcium dysregulation, mitochondrial dysfunction, ACE2/RAS imbalance, NF-κB inflammation, eNOS uncoupling (BH4 depletion), ferroptosis, NETs/DAMPs, senescence, and autoantibodies. B. FUNCTIONAL rarefaction (perfusion failure in remaining vessels) via amyloid fibrin microclots, NET-immunothrombosis, platelet activation, pericyte constriction, and RBC deformability issues. 3. These create a vicious cycle of patchy hypoxia, tissue ischemia, fibrosis, and organ dysfunction (brain fog, fatigue, cardiac issues, etc.), potentially progressing to an acquired systemic sclerosis-like state (“Spike Protein Endothelial Disease” or SPED). 4. Reinfection/vaccination: The document does not discuss reinfections or present any data on vaccination. It only proposes future studies to correlate capillary density with vaccination history and spike exposure. No mechanisms or comparisons between natural infection versus vaccine-derived spike are detailed. ➡️This proposal synthesizes prior evidence on persistent capillary rarefaction and spike-mediated endothelial injury into a unified “microvascular erasure” framework, distinguishing structural from functional damage and introducing the "SPED concept". Its bolder interpretive synthesis offers a coherent, hypothesis-generating model that indeed should merit further testing. ‼️So, following the authors, capillary rarefaction in LongC0VID represents not a temporary dysfunction but progressive, largely irreversible microvascular erasure. Once structural vessel loss occurs, downstream parenchyma is permanently orphaned in non-regenerative tissues (heart, brain, kidney), locking patients into chronic hypoxia and multi-organ decline. Spike-driven mechanisms turn a single exposure into a self-perpetuating disease process with “scleroderma-like” features, a sobering prospect of widespread, potentially permanent microvascular obliteration if unaddressed.🤔 Would greatly appreciate @resiapretorius thoughts? #AvoidSars2 #AvoidReinfections researchgate.net/profile/Abdul-…

"COVID-19-attributable neurological years lived with disability reached 30 to 40 years in adults.. the prevalence of cognitive impairment remained at 19.1% among individuals with mild to severe COVID-19 infection 2 years postinfection.. These disorders are structurally associated with whole-brain or region-specific atrophy.. COVID-19 patients would have unrecovered atrophy for global brain and specific brain structures after long-term follow-up, which is a typical sign of brain aging. In addition, RNA-seq analysis of 54 postmortem brain samples revealed that the COVID-19 brain was enriched for aging pathways.. In this study based on the genetic data [of 5,779,391 participants],..we found that advanced COVID-19 causally increased the risk of aging for the total brain." Protect your brain, please. 'Genetic evidence that advanced COVID-19 accelerates longitudinal brain atrophy: A Mendelian randomization study' journals.lww.com/md-journal/ful…

@AnnieForTruth Watch this video about Donald Trump's blatant corruption. We are talking about awarding illegal contracts, pay to play scheme, presidential pardons for cash, and Trump enriching his son Don Jr. It's pretty brutal: youtu.be/DaQ_95hPhu4?si…

A federal court just confirmed what everyone already knew: Trump’s DOJ is illegally using the machinery of government to target his political enemies with bogus investigations. That’s not justice. It’s corruption. IT MUST END!

Governor Tim Walz @GovTimWalz

3 weeks ago

I will never stop exercising my constitutional rights to stand up for Minnesotans and the American freedoms we hold dear. My full statement on DOJ’s politically motivated investigation:

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"Republicans already got away with treason 4 times — but they won't this time" - AlterNet #SmartNews l.smartnews.com/p-7Yl1Q45W/WPK…

How the fuck do we have $300 billion to rebuild Iran after we spent $80 billion bombing it, when we don’t “have the money” for pediatric cancer research?

The long-term cardiovascular risks of SARSCoV2 infection and reinfections Your heart is under silent, cumulative attack from SARSCoV2, and every reinfection can reload/worsen the damage. Here a personal recap of 10 important studies from the last 2 years showing exactly how this virus and its reinfections can/may shape (and shorten) your cardiovascular future. Evidence is clear, long-term, and growing. Print and show your Cardiologist. Let’s connect the dots… 1. Immunothrombosis multi-omics study: 3 months after hospitalisation, long COVID patients still have blood biologically “clot-ready” with persistent endothelial activation and prothrombotic signalling. x.com/HarrySpoelstra… 2. IL-6 & SAA 6-year study: Higher acute-phase IL-6 and SAA levels independently predict cardiovascular events and death up to 6 years later, the initial inflammatory storm leaves a lasting CV mark. x.com/HarrySpoelstra… 3. MIS-C long-term outcomes: Up to 4.5 years later, MIS-C raises cardiovascular disease risk 14× and hypertension 9× in children, with risks still accumulating. x.com/HarrySpoelstra… 4. Viruses & cardiac disease review: SARS-CoV-2 stands out for direct cardiomyocyte invasion + explosive damage + relentless accumulation of risk with every reinfection. x.com/HarrySpoelstra… 5. Mayo PET long COVID study: Persistent cerebral hypometabolism in fatigue/PEM patients still detectable up to 2 years post-infection. x.com/HarrySpoelstra… 6. Reinfection CV outcomes summary: Reinfections worsen cumulative heart damage, arrhythmias, thrombosis, stroke risk and long COVID cardiovascular symptoms. x.com/HarrySpoelstra… 7. Youth reinfection & long COVID study: Reinfection roughly doubles PASC risk, with myocarditis up to 3.6× higher, heart disease ~2× higher and increased thromboembolism. x.com/HarrySpoelstra… 8. Mild infection + reinfection risk: Even mild cases trigger lasting endothelial damage and prothrombotic state (1.5–2× long-term CV risk), each reinfection compounds the burden. x.com/HarrySpoelstra… 9 Mitochondrial dysfunction in long COVID: Persistent mitochondrial dysfunction and suppressed oxidative phosphorylation remain in long COVID, pointing to durable multi-organ impact. x.com/HarrySpoelstra… 10. Cumulative reinfection impact on future CV health: Reinfection stacks additional damage on prior endothelial injury and inflammation, increasing lifetime risk of heart failure, arrhythmias, thrombosis and accelerated cardiovascular disease. x.com/HarrySpoelstra… 11. Extra, my earlier general reminder post on this exact theme: x.com/HarrySpoelstra… ‼️Overall convergence across the studies: Immunothrombosis, acute inflammation markers, direct invasion, endothelial damage, and mitochondrial issues create lasting CV vulnerability that reinfections can keep reloading. #L0ngC0vid The pattern is very clear. Fewer infections = lower lifetime cardiovascular risk. You only have one heart. Protect it! #AvoidSars2 #AvoidReinfections #CleanAir #VaccineUpdated

Harry Spoelstra @HarrySpoelstra

4 months ago

🚨GENERAL REMINDER: YOU ONLY HAVE ONE HEART, TREAT IT WITH RESPECT! Reinfections aren't harmless "boosters", they stack the deck against your HEART, turning one hit into compounding long-term cardiovascular risks. ➡️3 important and recent articles (from 2025–2026) providing the

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BREAKING: Ken Paxton’s own lawyer just endorsed James Talarico: “I defended Ken Paxton for years in the impeachment trial and in state criminal cases. But in my view, I think Ken has lost sight of his core mission, which is to represent the people of Texas.  And unlike Ken, I believe that you, James, believe in unity over division and that you know how to assemble not only Democrats but Independents and Republicans and we need that right now.  We need unity, we don't need any more division and that's why I'm supporting you.”

@CalltoActivism @MADDEEE13

When I called out Trump years ago for being a danger to democracy, a free press, and truth itself, I was accused of making myself the story and showboating. How did things turn out? Trump is all of those things. Tonight, the free press is very much in danger in America. Wake up!

@

57 years ago

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Professor Omar Yaghi, a chemist at the University of California, Berkeley and winner of the 2025 Nobel Prize in Chemistry, has developed an innovative atmospheric water generator capable of producing up to 1,000 liters of clean drinking water per day directly from dry air. Using reticular chemistry and advanced metal-organic frameworks (MOFs), the system efficiently captures moisture even in arid desert conditions with very low humidity. The compact, shipping-container-sized units developed by Yaghi’s company, Atoco, operate entirely off-grid using only ultra-low-grade ambient thermal energy or sunlight, requiring no electricity from the grid. This sustainable technology offers a promising alternative to energy-intensive desalination plants, which often harm marine ecosystems through brine discharge. It is particularly valuable for remote communities, drought-prone regions, and areas affected by natural disasters such as hurricanes in the Caribbean, where centralized water infrastructure may fail. Yaghi’s personal experience growing up with water scarcity in a refugee community in Jordan has deeply influenced his work. He advocates for scaling decentralized, resilient solutions to address the global water crisis through scientific innovation. [Atoco official website and related coverage in Interesting Engineering, Food & Wine, and Nobel Prize announcements (2025–2026)]

There are lots of lists of symptoms of Long Covid, but I've been working on making a list of the mechanisms by which Covid causes them. It's not perfect, but here it is:

tern @1goodtern

a month ago

x.com/i/article/2060…

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@rparloff

I know for a fact people involved in forcing my son to go unmasked frequent my Twitter, LinkedIn etc. Here they can read scientific studies on the harm sarscov2 causes but they willfully choose to ignore it. And deny to be liable if he comes to harm because of their policy. HLP

“ ensitrelvir has come through.” — After successful trial in Japan, an anti-Covid-19 drug more effective than Paxlovid may be approved for use in the US in mid June.

nature @Nature

2 months ago

An antiviral pill has, for the first time, been shown to prevent COVID-19 in people exposed to the SARS-CoV-2 virus go.nature.com/4nAMi6g

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Norway just made a decision that will be remembered for years. The country has officially ended fur farming nationwide. No more mink or foxes will be bred, kept in cages, and killed for clothing. An industry built on animal suffering is now gone. This took years. Investigations exposed what life in fur farms looked like. Animals lived in small wire cages. They could not run, dig, or behave naturally. Many showed clear signs of stress. People saw the reality and spoke up. Public pressure grew. Animal welfare groups kept pushing. More citizens questioned whether fashion could justify that cruelty. Lawmakers responded and passed a ban. Farmers received time to transition and shut down their operations. That process is now complete. This matters. Thousands of animals will not be born into cages. Fewer lives will be treated like products. Norway chose compassion over tradition and profit. The impact also reaches beyond Norway. Decisions like this show other countries that change is possible. They push others to look at their own systems and ask if they still make sense. Consumers are driving this shift too. More people choose alternatives. More brands stop using fur. Demand is changing, and industries are forced to follow. This is what progress looks like. It builds over time through awareness, pressure, and action. Then one day, what once seemed normal is no longer accepted. Norway has drawn that line. Sources: - Euro Group for Animals: Fur farming ends in Norway as remaining farms close doors - Dyrevern: Breaking News: Norway bans fur farming

🚨 JUST IN: Scientists who warned about airborne COVID are now urging WHO to treat Andes hantavirus as airborne by default warning the world not to repeat past mistakes

President Obama on Iran: “We pulled it off without firing a missile. We got 97% of their enriched uranium out. There’s no dispute that it worked and we didn’t have to kill a whole bunch of people or shut down the Strait of Hormuz”

4 billion years of human evolution unfold in minutes [🎞️ thebrainmaze]

The Trump administration has downsized US science by historic margins — but it's not just via grant or workforce cuts. Our new @Nature analysis reveals the government has cut more than 100 scientific advisory panels across all major science agencies.