Yick Hin Ling @yhinling
Assistant Professor at Emory | Croucher Postdoctoral Fellow Transcription • Chromatin • Genetics • Single-molecule Imaging Joined May 2020-
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Leanna Owen, Margot Riggi, David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster. journals.biologists.com/jcs/article/13…
Free scientific illustrations for biologists! 😍 @NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov
Check out our latest work on Pol III @MolecularCell! We explore genomic “breadcrumbs” of Pol III activity at protein-coding genes🤯Congrats Rajendra K C and to co-authors Ruiying, Sihang, and Simon @MCB_Illinois and Duncan Smith @NYUBiology authors.elsevier.com/a/1jvax3vVUPRn…
Our paper @NatureSMB is online! We used a combination of single-molecule tracking, two-color PALM, and genomics methods to understand how pioneer transcription factors pioneer on chromatin, revealing a "confined target search" mechanism. nature.com/articles/s4159…
⚠️ Tag with Caution ⚠️ New preprint led by @DoernerKerstin in @MariaHondele lab with contributions from @fancaoErik on our side on the effects of tagging with FPs and peptides on condensation and phase separation Summary: It’s complicated See more: doi.org/10.1101/2024.1…
Tag with Caution - How protein tagging influences the formation of condensates biorxiv.org/cgi/content/sh… #biorxiv_molbio
🌌 Dive into the world of RNA Pol II, where tiny "alien" is actually clusters of Pol II CTD in different post-translational modes, forming distinctive phase-separated droplets with unique role in transcription. Check out our new paper just published 👉 rdcu.be/dTLIX
In our new paper aided by single molecule imaging of RNA and transcription machinery we demonstrate how Polycomb Repressive Complex (PRC) represses transcription in live cells 🧵 nature.com/articles/s4155… 1/9
Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab! doi.org/10.1038/s41592… 1/11
Great Idea for Poster presentation...!!! Via Caroline O'Donnell/O'Flaherty Lab (Linkedin) #scicomm #scienceoutreach #sciencetalk #scienceposter
Out today from the Vandenberg and Dedecker labs! PSF splitting with the ‘Circulator’, which encodes the fluorophore emission band into the PSF, improves the information content of fluorescence microscopy and enables improved super-resolution imaging and single-particle tracking.
Thr4 phosphorylation in Pol II CTD is a "phantom mark," hidden until long after transcription ends! 👻 Our recent paper shows it's masked by nearby Ser5 phosphorylation, and we revealed it using a specific phosphatase. Read more: bit.ly/3MVNLTf #Transcription
Great wish list for SMLM future by @rita_strack ! 💯 👏🏻👏🏻 #SMLMS2024
Excited to share our new paper @NatureComms. bit.ly/3WUkxbJ Single-nucleosome imaging reveals that condensins act as molecular crosslinkers, locally constraining nucleosomes to organize mitotic chromosomes. Nucleosome-nucleosome interactions constrain whole chromosomes.
Bayesian nonparametric Track (BNP-Track) simultaneously determines emitter numbers and their tracks alongside uncertainty, extending the super-resolution paradigm from static samples to single-particle tracking even in dense environments. @LabPresse nature.com/articles/s4159…
Excited to launch our cloud-based image analysis platform today at nimbusimage.org! Analyze and interact with your data, all in the browser. Follow sign-up instructions to request an account.
Highlights: • Analyzed dynamics of over 50 transcription-associated proteins. • Uncovered significant kinetic differences among RNA polymerase PICs. • Dynamic interactions of elongation factors refine traditional assumptions from static biochemical methods.
New preprint: We've used single-molecule tracking to explore the dynamics of 50+ proteins associated with RNAPI, RNAPII, and RNAPIII transcription machineries in live yeast.🔬 biorxiv.org/content/10.110… #Transcription #SingleMolecule #RNAPolymerase #Genetics #Biophysics #Chromatin
We present: 'Multispectral live-cell imaging with uncompromised spatiotemporal resolution'. biorxiv.org/content/10.110… 1/16
Happy and excited to share our new @biorxivpreprint on long-term single-molecule imaging!! 🔬💥 #Breakthrough , #ProudPI biorxiv.org/content/10.110… @ZMBP_Tuebingen @sfb1101 @uni_tue #TRR356 Nano-🧵👇
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