Al Garfall @AlGarfall
Oncologist @PennMedicine @PennCancer specializing in multiple myeloma and cellular immunotherapy. Philadelphia, PA Joined July 2014-
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Anti-BCMA TCE in newly diagnosed myeloma. New era is here, end of HCT? congrats @RaabMarc @RascheLeo nature.com/articles/s4159…
Bryce Harper’s first career cycle with crowd noise only….. Pure goosebumps
@End_myeloma @JanakiramMurali @CoachBon @RahulBanerjeeMD @BloodPortfolio @hhashmi87 @BloodAdvances Given these exceptionally effective options, pick the safest one rather than get tied in knots on sequencing debates based on retrospective studies that can’t possibly answer the sequencing question in an unbiased way.
@End_myeloma @JanakiramMurali @CoachBon @RahulBanerjeeMD @BloodPortfolio @hhashmi87 @BloodAdvances Agree with both @End_myeloma and @JanakiramMurali, except to note that they are making efficacy arguments and setting aside toxicity. Sequencing is predicated on failure of the first therapy efficacy-wise AND surviving its toxicity.
@JanakiramMurali @CoachBon @RahulBanerjeeMD @BloodPortfolio @hhashmi87 @BloodAdvances Great point. The relevance of sequencing is predicated on the failure of the first therapy in the sequence. As we move immunotherapy to earlier populations, failure will be minimal, diminishing the hypothetical implications for sequencing.
New CAR T treatment opens doors for kidney patients ft. Ali Naji (@pennsurgery), Mary Kaminski, @krjmd (@Penn_Transplant), Vijay Bhoj, @malekkam1, @carlhjune, Nicholas Brown (@PennPathLabMed), Sabiha Hussain (@PennKidney) & @AlGarfall (@PennCancer) tinyurl.com/ykvbx4c4
My summary of CARTITUDE4, MajesTEC3, MajesTEC9 and MoumenTAL3. In anti-CD38 refractory patients and EMDs -->TCE anti-BCMA or anti-GPRC5D are >> to Cilta-Cel
@Eddie_Cliff @NatRevClinOncol @rajshekharucms @ManniMD1 @DianaNrco Nice commentary. I mostly agree as I outlined in this friendly exchange with @Rfonsi1: rafaelfonseca.substack.com/p/rebuttal-to-… Cilta-cel still has a role after bsAb or before in pts who prefer it and fully understand risk. There are still many data gaps.
Arlo-cel (anti-GPRC5D CAR T-cell) in Rel/ref MM. N=84, 5 prior lines of Rx, 49% anti-BCMA-exposed. CRS: 82%, ICANS 10%, other NT: 12%. Skin/nail AE: 30/19%, oral AE: 32%. ORR 87%, median PFS: 18.3 months #mmsm #bmtsm @SusanBal9 @BloodPortfolio ashpublications.org/blood/article/…
It's been immensely gratifying to learn from this diverse team of innovative experts and, most of all, to see our patients do well: inquirer.com/health/car-t-a…
This ongoing study (NCT06056102) is a collaboration between transplant surgery, nephrology, pathology, hematology/oncology, and cellular therapy programs at three centers (Penn, NYU, MGH), all supported by @NIH.
Proud to have contributed to this study @PennMedicine of dual CD19/BCMA-directed CAR T cells to reduce anti-HLA antibodies in highly sensitized patients in need of kidney transplant: nejm.org/doi/full/10.10…
One of the most rewarding and emotional moments of my career took place at #ASCO2026. In 2015, I started the first-in-human trial of 11-1F4 (now anselamimab), supported by a small FDA grant and @columbiacancer. At the time, the path forward was far from certain. We faced limited funding, strong competition from Prothena’s NEOD001 program, and considerable skepticism from industry given the rarity of AL amyloidosis and the fact that competing programs were already much further advanced in development. Despite these challenges, we continued to move forward step by step. The phase 1 study demonstrated encouraging results, ultimately leading to the founding and funding of Caelum Biosciences in 2017 and the launch of the subsequent phase 2 and phase 3 studies. Those efforts were later advanced and completed through the commitment and resources of @AlexionCARES and @AstraZenecaUS. @ASCO I had the privilege of chairing the session when the final phase 3 results where presented by Dr. Wechalekar, which demonstrated a significant overall survival benefit in patients with stage IIIA/IIIB κ AL amyloidosis🙌. Seeing a scientific concept evolve from an investigator-initiated first-in-human study into a positive phase 3 trial is extraordinarily rewarding. This achievement reflects the dedication of countless patients, supporters🙏@MorieGertz, investigators, research staff, industry partners, and advocates who believed in this program over many years. It is also a powerful reminder of why we do translational research-to transform promising science into therapies that meaningfully improve patients' lives. #ASCO2026 #ALAmyloidosis @Amyloidosis_ARC @Amyloidosisfdn @AmyloidosisSupp @ISA_Amyloidosis
@Rfonsi1 @HiraSMian @rajshekharucms @RahulBanerjeeMD @DrRakeshPopat @bdermanmd @HadidiSamer Agree need to watch for this. I have not seen this with Tec. We have seen PN with cilta-cel; paper on this coming out soon.
Good commentary from @IrenemGhobrial on the complicated question of whether clonotypic B cells are clinically relevant in #mmsm. New Insights into the Role of Clonotypic B Cells in Plasma-cell Neoplasia …rjournals-org.proxy.library.upenn.edu/bloodcancerdis…
@rajshekharucms I argue here for bsab before cilta-cel based on tec3 and tec9: open.substack.com/pub/rafaelfons… Story may change later with safer CAR, but this is my preference for now.
#mmsm #ASCO26 MajesTEC-9 ➡️Tec vs. PVd/Kd (1-3 prior lines of therapy) ➡️Len refractory: 80%; anti-CD38 refractory: 85% ➡️median F/U ~1.5 yrs ➡️18-mo PFS rate: 70% vs 27% ➡️improved OS with Tec vs PVd/Kd (HR: 0.60), even with >2/3 of pts getting BsAb or CAR-T as subsequent treatment 🛑Gr 5 TEAEs (6.5% vs 3.5%)-higher with Tec vs PVd/Kd 🛑Gr 3/4 infections were higher with Tec vs PVd/Kd (42% vs 29%) Teclistamab single agent in anti-CD38 refractory is a great option to have in early relapsed myeloma asco.org/abstracts-pres…
@RahulBanerjeeMD @SLentzsch @H_Einsele @COMyCongress Case series of this approach @BCD_AACR pubmed.ncbi.nlm.nih.gov/41810881/
Excellent summary of CAR-PRISM by @HadidiSamer: “For an asymptomatic condition with a risk to progress to a condition that has excellent treatment options and outcomes (and despite the deep responses) those toxicities reported are really concerning”!
6️⃣What is the efficacy ? This is a secondary goal (the most important Q in this study was safety) ✅ median follow up: 15 months ✅ MRD negativity 10−6 by 2 months: 100% Deep responses , short follow up to assess durability Bottom line For asymptomatic condition with a
Rahul Banerjee, MD, F... @RahulBanerjeeMD
12K Followers 4K Following Asst Professor @UWMedicine @fredhutch. Goals: improve pt experience in myeloma #MMsm: ⬇️ dex, ⬆️ time at home, 📱-based wellness. COI: https://t.co/3Uuojuio6R
Saad Z. Usmani MD MBA... @szusmani
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Rafael Fonseca MD �... @Rfonsi1
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Rafael Fonseca MD �... @Rfonsi1
16K Followers 3K Following Chief Innovation Officer - Mayo Clinic in Arizona. Myeloma doctor. Visiting Healthcare Fellow @GoldwaterInst. Tweets-own/RT not an endorsement
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