Barmada Lab @BarmadaLab
Barmada lab @UMich. We study cellular mechanisms underlying ALS/FTD & RNA biology with focus on neurodegeneration. (group-run account) barmadalab.com Ann Arbor, MI Joined May 2020-
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New preprint from our and @BillDauerNeuro labs, also with @pappassa! @suminkim28 characterized neuronal NPC biogenesis and implicates mislocalized/delayed NPC assembly in DYT1 dystonia. See tweetorial below ⬇️
Excited to share my thesis work! Using super-resolution microscopy and a new HaloTag-Nup107 mouse line, we find that 1) NPC biogenesis is upregulated during neuronal maturation and that 2) torsinA is essential for normal localization and assembly kinetics of neuronal NPCs. (1/N)
Our work on matrin3 is now out on PNAS: pnas.org/doi/10.1073/pn… Congratulations to all authors!
Another preprint out from our lab! MATR3 abundance and RNA binding are regulated by neuronal activity, and pathological mutations disrupt activity mediated degradation of MATR3 via calpain1. This links activity dependent regulation of MATR3 and disease! biorxiv.org/content/10.110…
Just OUT: A fantastic commentary on our paper by @EmilePinarbasi & @BarmadaLab! @jclinicalinvest doi.org/10.1172/JCI168… Thank you so much!
@UMneurosciences @MolecularCell Great overview of the link between RNA methylation and ALS!
🎉NEW SPEAKER! 🗣️Dr. Sami Barmada @BarmadaLab 🗓️15th June '23, 11 am EST 📝us06web.zoom.us/webinar/regist…
We have an opening for a postdoc! Come work with us on ALS/FTD ⬇️
Another preprint out from our lab! MATR3 abundance and RNA binding are regulated by neuronal activity, and pathological mutations disrupt activity mediated degradation of MATR3 via calpain1. This links activity dependent regulation of MATR3 and disease! biorxiv.org/content/10.110…
@OscarWilkins16 Thanks Oscar - this is excellent.
Our story on m6A and TDP43 is now out in Molecular Cell! sciencedirect.com/science/articl…
Excited to share that our latest preprint is out! Here we show that m6A modulates TDP43 RNA binding and that RNAs are hypermethylated in ALS. We also found if you knockdown an m6A reader, YTHDF2, you can mitigate disease related toxicity!
@OscarWilkins16 An additional issue is the scarcity of the material — we try to make the most out of available tissue, which as you mentioned may bias towards false positives (or negatives). The solution would be to measure from fewer cells/sample but more samples. Harder in practice.
@OscarWilkins16 Not quite the same. Better would be hair length in City A vs. B (but only from a sparsely populated neighborhood). We measure 100+ hairs from 3 people in City A vs. B. This way we don't throw out error estimates and variability among hairs.
@NonselfMutation @BoeynaemsSteven The excess m6A we noted in patient tissues could very well be due to neuroinflammation. Similar changes were noted by Jiang et al. (10.1016/j.molcel.2021.07.038) in Alzheimer's brain, which also shows significant inflammation.
@OscarWilkins16 Thanks Oscar. The 3 biological replicates are indicated by shading while N refers to individual neurons. While the effect is not large it is statistically significant. We suspect YTHDF2 deposits only in a subset of the neurons, but definitely need to look in more patient samples!
Also, Sami will be giving a talk on MTMR5 and neuronal autophagy at 4:53pm in the "Mechanisms of Autophagic and Endolysosomal Trafficking in Neuronal Function and Neurodegeneration" subgroup tomorrow! #CellBio2022
Check out our lab's posters at #CellBio2022 tomorrow (Monday Dec 5)! - Genesis Rodriguez on VPS13A function in mitochondria/ER (P2106/B430) - Josephine Wu on calcium and calmodulin-dependent Matrin3 homeostasis (P2076/B399) - Sumin Kim on neuronal NPC biogenesis (P2019/B339)
Check out our lab's posters at #CellBio2022 tomorrow (Monday Dec 5)! - Genesis Rodriguez on VPS13A function in mitochondria/ER (P2106/B430) - Josephine Wu on calcium and calmodulin-dependent Matrin3 homeostasis (P2076/B399) - Sumin Kim on neuronal NPC biogenesis (P2019/B339)
6 @UMich scientists & engineers have been named the 2022 winners of the #MBioFAR Award, which recognizes exceptional mid-career faculty in the biosciences. Congrats @BarmadaLab @fu_jianping @LyssiotisLab @AlisonNarayanUM, James Moon, Elizabeth Speliotes. news.umich.edu/six-u-m-resear…
Congratulations to @AlisonNarayanUM, who has been named a 2022 MBioFAR awardee! This #UMBiosciences award recognizes exceptional mid-career faculty in the biosciences and supports their continued pursuit of innovative, high-risk research. record.umich.edu/articles/six-u…
Congrats @SEWrightPhD!
Our newest paper is out! @SEWrightPhD and friends discovered that RAN translation of CGG repeats triggers translational frameshifts that create toxic aggregation-prone chimeric proteins! A quick 🧵1/5: #FragileX #ALS #dementia academic.oup.com/nar/advance-ar…
Excited to share that our latest preprint is out! Here we show that m6A modulates TDP43 RNA binding and that RNAs are hypermethylated in ALS. We also found if you knockdown an m6A reader, YTHDF2, you can mitigate disease related toxicity!
Congratulations to Mike on a fantastic thesis defense today! Mike’s work on m6A and TDP43 opened up many new avenues for the lab to pursue, and he has been pivotal in introducing the lab to science memes. Great job and many congratulations, Dr. McMillan!
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