Perlson lab @LabPerlson
🔬 Molecular Neurodegeneration research group at Tel Aviv University, Israel www3.tau.ac.il/medicine/perls… Tel Aviv, Israel Joined February 2019-
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Perlson lab retweeted
RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons jneurosci.org/content/44/15/…
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Perlson lab retweeted
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive weakness due to degeneration of upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord. Learn more in this Review: ja.ma/3Q8S0jq
Perlson lab retweeted
Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation | EMBO Reports | Springer Nature Link link.springer.com/article/10.103…
Perlson lab retweeted
Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain - Walker - 2026 - Protein Science - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/pr…
Perlson lab retweeted
Mecca et al. investigate the role of muscle stem cells in SMA and show that their depletion disrupts neuromuscular junctions and leads to motor neuron loss in the spinal cord. They conclude that muscle stem cells represent potential therapeutic targets. shorturl.at/vIwEU
Perlson lab retweeted
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons embopress.org/doi/full/10.10…
Perlson lab retweeted
Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo researchsquare.com/article/rs-762…
Perlson lab retweeted
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons | The EMBO Journal embopress.org/doi/full/10.10…
Perlson lab retweeted
KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS biorxiv.org/content/10.110… #biorxiv_neursci
Perlson lab retweeted
Cell size-dependent mRNA transcription drives proteome remodeling biorxiv.org/content/10.110…
Perlson lab retweeted
Read this excellent story from the @jltwiss1 lab. Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration biorxiv.org/content/10.110…
Perlson lab retweeted
O'Brien et al. demonstrate a link between ALS and extreme exercise in males which is potentially mediated via failed mTOR signalling at the neuromuscular junction. tinyurl.com/cajta7y3; tinyurl.com/ymd5c6h4
Perlson lab retweeted
Drs. Yi Zeng, Aaron Gitler, and colleagues show that loss of TDP-43 from neuronal nuclei of human brain and disease-causing mutations in TDP-43 are associated with widespread changes in alternative polyadenylation. 🧠 @StanfordMed @NatureNeuro | go.nature.com/473g5Oe
Perlson lab retweeted
Retrotransposons unplugged: Rewiring the nervous system and wreaking havoc: Neuron cell.com/neuron/fulltex…
Perlson lab retweeted
Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse model of amyotrophic lateral sclerosis: biorxiv.org/content/10.110…
Our cover art suggestion. Firefighters spraying mir126 balloons to douse the flames- toxic TDP-43 aggregates that damage axons and neuromuscular junction in ALS. Illustration by Maayan Visuals. nature.com/articles/s4159…
By uncovering a new mechanism that drives ALS progression and identifies a potential therapeutic target, we hope this work opens up new avenues for intervention. Grateful to my brilliant team and collaborators for making this possible.
Thrilled to share our new work in Nature Neuroscience! Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS. nature.com/articles/s4159…
This reveals a novel muscle-to-motor neuron communication axis, where loss of miR-126 triggers TDP-43 accumulation, NMJ disruption, and motor decline. Restoring miR-126 demonstrated neuroprotective effects in both mouse and human ALS models.
Perlson lab retweeted
Translation landscape of stress granules | Science Advances science.org/doi/10.1126/sc…
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