Constantijn Scharlee @CScharlee28
Medical student, @KU_Leuven🇧🇪 🇳🇱 affiliate researcher @broadinstitute (Getz lab), visiting grad student @emblebi (Coorens group) Cambridge, MA Joined August 2023-
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Constantijn Scharlee retweeted
Recently spotlighted in @Nature, a new BioRxiv preprint showcases a single-cell sequencing approach that reveals somatic mutations, chromosomal changes, and lineage insights often missed in bulk data. Uncover the science behind it: nature.com/articles/d4158…
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Constantijn Scharlee retweeted
A comprehensive view of somatic mosaicism by single-cell DNA analysis biorxiv.org/content/10.110… #biorxiv_genomic
Constantijn Scharlee retweeted
Welcome, Tim Coorens 🇳🇱, our new Research Group Leader. Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease. ebi.ac.uk/about/news/per…
Constantijn Scharlee retweeted
The Coorens group at @emblebi is hiring a postdoc! 📍 Hinxton, UK 🗓️ Apply by July 25 embl.wd103.myworkdayjobs.com/EMBL/job/Hinxt…
Constantijn Scharlee retweeted
The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature nature.com/articles/s4158…
Constantijn Scharlee retweeted
🧬 The SMaHT marker paper is now live in @Nature This landmark study characterizes somatic variation across 19 tissue types from 150 nondiseased donors, laying the groundwork for future discoveries in health, aging, and disease. Read the full paper: nature.com/articles/s4158…
Constantijn Scharlee retweeted
We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." @Nature nature.com/articles/s4158…
Constantijn Scharlee retweeted
1/ 🧵Check out our new study in @NatureGenet, which examines how precancerous conditions (MGUS/SMM) evolve into Multiple Myeloma, and offers new computational methods to predict progression risk and model cancer evolution. doi.org/10.1038/s41588…
Constantijn Scharlee retweeted
What if LLMs could “read” & “write” biology? 🤔 Introducing C2S‑Scale—a @Yale + @GoogleAI @GoogleDeepMind collab: we scaled LLMs (up to 27 B!) to analyze & generate single‑cell insights by turning transcriptomes into text 🧬➡️📝 🔗 Blog: research.google/blog/teaching-… 🔗 Preprint: biorxiv.org/content/10.110… #SingleCell #AI #LLM
@S_J_Aitken @aitken_lab @MRC_TU @_HAN1999 @clarnedo @Aine_McColgan @mark_southwood @Cambridge_Uni @Cambridge_SBS @CRUKresearch Wishing you and the lab the very best regarding the move! These figurines are lovely (the one in the lefthand corner looks quite familiar)!
@TimCoorens @emblebi Great news, Tim, congratulations!
@aitken_lab @clarnedo @MRC_TU @Cambridge_SBS @EarlyCancerCam @Cambridge_Uni @ClaudiaFlandoli 👏👏
@S_J_Aitken @aitken_lab @KU_Leuven @clarnedo @anghel_malina @mark_southwood @MRC_TU @Cambridge_SBS @Cambridge_Uni @vib_ccb Certainly, I look forward to it!
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