Andrés Caicedo Lab @CaicedoLab

Working together to transmit knowledge and experience to young, promising physicians, researchers, and innovators is a true privilege. Through mentorship, we help shape the future of medicine, science, and advanced therapies. 🧬🩺 The Cell and Gene Therapy Club, part of the @ISCTglobal , International Society for Cell & Gene Therapy, is an international initiative that connects students with the rapidly evolving field of advanced therapies. From Ecuador, our chapter proudly organized its first Scientific Writing Hackathon at @usfq_Ecuador , creating a space where students learned how to identify real scientific needs, build strong rationales, and transform ideas into meaningful research manuscripts. ✍️🔬 This initiative was made possible through the guidance and commitment of an interdisciplinary team of mentors: Andrés Caicedo and @gulnaraborja from the USFQ School of Medicine, @RamiroDíaz from the School of Veterinary Medicine, and Juan Carlos Collantes, PhD, from the School of Biological Sciences. 👏 We are proud of the outstanding participation of our young ESPs: Martina Pinto, David Párraga, Sajar Segovia, and Sofía Albuja, who embraced scientific communication and writing as essential tools for their future professional journeys. 🌟 Thank you to Universidad San Francisco de Quito and ISCT, International Society for Cell & Gene Therapy, for supporting this initiative and helping us build a stronger scientific community from Ecuador to the world. 🌎 Science advances when knowledge is shared, mentored, and transformed into action. 🚀 @usfqB @AemUsfq @usfq

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The aging extracellular matrix as a missing link in senescent cell accumulation and persistence nature.com/articles/s4358…

¡Tercos y resilientes! ¡Vamos, ecuatorianos! 🇪🇨💪

🌎 Welcoming the World to Our Lab at USFQ I am proud to welcome Sophie Ledee from Cornell University and Stella Morger from ETH Zürich to our lab at the @USFQ_Ecuador School of Medicine. 🧬🔬 Sophie and Stella will work alongside our team using molecular analysis and bioinformatics approaches to help us advance regenerative strategies, understand oxidative stress, and identify novel disease biomarkers. 💡International exchanges like this one are at the heart of scientific progress. They bring fresh perspectives, strengthen academic collaboration, and remind us that the best science is built through shared curiosity across borders. 🤝🌍 A warm thank you to the amazing team who made Sophie and Stella feel at home from day one: Abigail Benavides, Doménica Pintado, and Sorely Ocapana, with the mentorship of Verónica Castañeda in bioinformatics. 🙌We are also deeply grateful to the Global Internships Program, especially Isabel Barona and Felipe Ante, and to the USFQ School of Medicine, including María Augusta Vélez, Pablo de la Cerda, and Marisol Bahamonde, for their coordination and support. ✨Welcome, Sophie and Stella. We are excited to build new bridges through science, education, and international collaboration. 🚀#USFQ #GlobalInternships #InternationalExchange #RegenerativeMedicine #DiseaseBiomarkers #CornellUniversity #ETHZurich #ScienceWithoutBorders

China has approved the first CAR-T therapy for a solid tumour, satri-cel, which targets claudin 18.2. Find out more about claudins as therapeutic targets in cancer in this recent comprehensive review nature.com/articles/s4157… rdcu.be/fp0UQ

Our immune response loses its integrity and protection as we age. If we're going to promote healthspan, we'll need to counter that loss of function and, at the same time, avoid inducing autoimmune diseases A new @jclinicalinvest review, open-access jci.org/articles/view/…

Nature research paper: Mutation-dependent responses to sleep and exercise in clonal haematopoiesis go.nature.com/4xpf12h

Understanding the somatic evolution of metabolic traits dlvr.it/TT43zq

🔥Genomics of aging in @Nature !!🔥 nature.com/articles/s4158…

Cell-autonomous immunity model of aging and disease: Trends Open cell.com/trends-open/fu…

🚨NEW @NEJM CAR T cells expanding applications! Here CAR T facilitate kidney transplantation in highly sensitized people. dual CD19 + BCMA CAR T enabled kidney transplantation in two highly sensitized patients after reducing anti-donor antibody barriers, with no severe CRS/neurotoxicity. Another CAR T 1st @PennMedicine

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A fascinating milestone at the frontier of quantum computing and genomics! Loading a complete viral genome onto a quantum computer is not yet a direct biomedical discovery, but it represents an important step toward making quantum genomics experimentally viable. The real promise of quantum pangenomics may lie in its capacity to help us analyze genetic diversity, host–pathogen interactions, and complex genomic variation at scales that are increasingly difficult for classical computing. This could eventually open new ways to understand biological regulation, disease susceptibility, and precision medicine. A bold and inspiring example of interdisciplinary science expanding the computational limits of biological discovery. Congratulations to Sergii Strelchuk and the teams at @UniofOxford, Wellcome Sanger Institute, Cambridge, IBM, and Wellcome Leap.

University of Oxford @UniofOxford

a month ago

NEW: Oxford researchers have helped to achieve a world first: loading a complete genome onto a quantum computer. This makes an important step towards a future where quantum computing accelerates biological discovery. Find out more ⬇️ bit.ly/4u7Qr3h

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📢 Awards for Innovation, Inventorship, and Patents: What Is Behind Them? 📡 For the third consecutive year, I am deeply honored to have received recognition for #BestInnovation in #TechnologyTransfer by @CEDIAec (Corporación Ecuatoriana para el Desarrollo de la Investigación y la Academia). 💡 Behind this award, there is much more than a patent, a certificate, or a public recognition. There is a strong motivation to address scientific and societal needs through research-based innovation. In our case, this means developing technologies that may contribute to better biomarkers, improved regenerative strategies, and new ways to understand and repair damaged tissues. 🫴 Innovation is not easy, especially in contexts where the ecosystem is still growing. In #Ecuador, we are only beginning to consolidate a stronger environment for science, intellectual property, technology transfer, and university-industry collaboration. In this path, the role of CEDIA has been essential in helping build bridges, capacities, and opportunities for researchers and institutions. 🧠 One of the most important lessons I take from this process is that a patent is not the final goal. A patent is a tool. It helps us valorize research efforts, reduce uncertainty, understand where value can be created, and make better decisions: what to protect, what to publish, what to license, what to abandon, where to invest, and with whom to collaborate. 🎖️ A strong intellectual property strategy is not measured only by the number of patents obtained, but by the quality of the decisions those patents help us make and by the impact they can generate when connected to real-world needs. 🧭 I am amazed and honored to share this achievement with outstanding scientists and colleagues. Special congratulations to @ValeriaOchoaHe2 for receiving the award for Best Innovation for Sustainability, and to @JuanCarlosCollantes, PhD for being recognized as this year’s Best Inventor. 🚀 My sincere thanks to María Laura Fuenzalida and @Alejo_bermeo , who lead the Universidad San Francisco de Quito Technology Transfer Office, and to the leadership of the @USFQ_Ecuador for supporting a vision where scientific discoveries can move beyond the laboratory and become solutions for society. ☄️ Inventions are key to transferring the value of scientific discoveries into everyday solutions. They generate motivation, new ventures, institutional growth, and a culture where science is not only published, but also transformed into impact. Grateful for this recognition and even more motivated to keep building science, innovation, and technology transfer from Ecuador to the world. 🚀 @DatoCienciaEC @edicionmedEC @UsfqB

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Scientists are developing a new wave of gene therapies to regenerate the heart — offering hope for treating heart failure, a debilitating and common condition. go.nature.com/3PvDZfv

How animals sense Earth’s magnetic field is one of biology’s enduring mysteries. Researchers in Science have now identified superparamagnetic macrophages in the livers of rock pigeons to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation. Learn more in this week's issue: scim.ag/4uAKQDl

Gene expression can be used to predict age and mortality 🚨 Impressive study from @gladyshev_lab @harvardmed using RNA-seq data to develop accurate transcriptomic clocks across mammalian species (inc. humans) and tissues to predict age, lifespan and mortality. A great example of the power of big data in aging research. Major processes changing with age include inflammation, mitochondrial function, epigenetic regulation, cell cycle (inc. markers of cellular senescence) and extracellular matrix remodeling. These clocks will have applications in personalised medicine, drug discovery and clinical trials. They also suggest some degree of coordination of aging changes. However, many questions remains. Are age-related transcriptomic changes drivers of aging or merely passengers? In other words, if we normalized these aging changes back to youthful levels, would this be beneficial, detrimental, or have no effect? And with so many aging clocks now available, how will researchers determine which ones are most biologically meaningful and clinically useful? Link to original paper: nature.com/articles/s4158… My thoughts on the study: nature.com/articles/d4158…

Human haematopoietic stem cells remember inflammatory stress | Nature nature.com/articles/s4158…

📢 Los espacios de interacción para fortalecer la #innovación en #Ecuador son más necesarios que nunca. Desde mi experiencia impulsando proyectos científicos con potencial de transferencia tecnológica y desarrollando procesos de propiedad intelectual y patentes en la @USFQ_Ecuador, he aprendido que la innovación no ocurre de manera aislada. Las ideas necesitan ecosistemas, conversaciones, aliados estratégicos y espacios donde puedan madurar hasta convertirse en impacto real. 💡 Por eso, iniciativas como @CEDIAec hashtag#IGNOVA son tan importantes para el país. 💡 Ecuador tiene talento, ciencia, creatividad y capacidad de generar soluciones propias. Sin embargo, para que ese conocimiento se transforme en tecnología, emprendimientos, patentes, productos o servicios con impacto, necesitamos conectar de mejor manera a la academia, la industria, el sector público y el ecosistema de innovación. Felicidades CEDIA por el evento #IGNOVA que se proyecta como un punto de encuentro clave para quienes están impulsando la transformación digital, la ciencia aplicada y la innovación tecnológica en Ecuador y la región. Abordamos ejes temáticos y desafíos fundamentales: 🔹 Gestión de la innovación en organizaciones y ecosistemas de CTI 🔹 Propiedad intelectual y explotación de activos intangibles 🔹 Clústeres académico-productivos y conexión de agentes de innovación 🔹 Aprendizajes internacionales y transferencia contextualizada 🔹 VTIC: de la investigación a la transferencia tecnológica Hoy más que nunca, Ecuador necesita espacios donde la ciencia dialogue con la industria, donde las patentes no sean vistas solo como documentos legales, sino como herramientas para crear valor, y donde la innovación se traduzca en desarrollo, competitividad y bienestar para la sociedad. @DatoCienciaEC @edicionmedEC

@BrestoffLab Dear @BrestoffLab, thank you very much for your support!

🚀 ¡Nivel desbloqueado! 🔬 Hace 10 años veía muy lejano poder alcanzar la categoría más alta de investigadores en Ecuador. Hoy, después de mucho trabajo en equipo, artículos, proyectos, retos, maestrías y doctorados acompañados, recibo este logro con enorme gratitud. Gracias, @EduSuperiorEc @SerBachillerEc 🙏✨ Mi gran gratitud a cada colega, amigo y colaborador que me dio la mano para seguir adelante y construir ciencia desde Ecuador con ambición, rigor y corazón. 💡🤝 Gracias a mis chicos, porque compartir este camino con ustedes ha sido una de las partes más valiosas de todo este proceso. Verlos crecer, cuestionar, investigar y soñar juntos nos recuerda que la ciencia se construye en comunidad. 🧬👩‍🔬👨‍🔬 Al final, cada paso, cada reto y cada aprendizaje construyen el camino, incluso más allá de cumplir una meta.🚀 Gracias, equipo. Gracias, @USFQ_Ecuador . Gracias a Dios por este gran logro. 🙏🔬🇪🇨✨ lnkd.in/etwAiaJK

The unbearable presence of senescent cells in ageing | Nature Reviews Genetics nature.com/articles/s4157…