MGH JWChen Lab @MGHChenLab
Associate Professor, Harvard Medical School; Radiologist and Director, Institute for Innovation in Imaging, Massachusetts General Hospital i3.mgh.harvard.edu Charlestown Waterfront, Boston Joined August 2019-
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Grand opening of the i3, with Dr. Dubach, Associate Director of the i3, discussing i3 services, facilities, and equipment. @JimBrinkMD @MGH_RI @MGHImaging
Grand opening of the i3, with Dr. Brink, Chief of MGB Enterprise Radiology, describing the founding of the i3. @MGHImaging @MGH_RI @JimBrinkMD
Grand opening of the i3, with Dr. Arnold, Executive Director of the CTRU, describing the collaboration between i3 and IBC to form the CTRU to provide translational clinical research services. @MGH_RI
Grand opening of the i3, with Dr. Caravan, Co-Director of the i3, giving examples of translational work and first-in-man studies. @JimBrinkMD @MGH_RI @MGHImaging @PeterCaravan
Grand opening of the i3, reception, with everyone having a great time. @MGH_RI @MGHImaging
Grand opening of the i3, with Dr. Chen, Co-Director of the i3, giving an overview of the i3. @MGHImaging @MGH_RI @JimBrinkMD @MGHChenLab
Grand opening of the i3, ribbon cutting, with Drs. Brink (center), Rosen (left), Weissleder (right), Caravan (far left), and Chen (far right). @JimBrinkMD @MGH_RI @MGHImaging @WeisslederLab @MGHCSB @MGHChenLab
In this editorial, Dr. Chen discusses results from the article by Akai et al. on mouse model investigation of gadolinium brain deposition and behavioral testing, as well as the safety and medicolegal impact of these results. bit.ly/3gPgGss @MGHChenLab @HarvardMed
Administration of gadolinium-based contrast agents (GBCAs) in mice showed deposition in deep cerebellar nuclei with linear agents. Behavioral testing on these mice showed no effects on motor activity, anxiety, or memory. bit.ly/3mRFCDj #NeuroRad
Myeloperoxidase, a highly oxidizing enzyme, exerts anti-tumor activity in glioma after radiotherapy. This could help optimize host immune response and therapy for this devastating disease. sciencedirect.com/science/articl… @MGHCSB @JimBrinkMD @mghradchiefs @MGH_RI @MGHNeuroRad @i3MGH
D-mannose, a commonly available dietary supplement and a simple sugar, can improve neuroinflammation by suppressing oxidative stress and blocking phagocytosis. doi.org/10.1073/pnas.2… @PNASNews @MGHCSB @JimBrinkMD @mghradchiefs @MGH_RI @MGHNeuroRad @i3MGH @CaravanLabMGH
Great symposium on translational imaging of inflammation coming up at the end of October. Hope to see you there! i3.mgh.harvard.edu/inflammation/ @i3Symposium2021 @MGHCSB @MGHImaging @MGHMartinos @MGH_RI @MGHNeuroRad @JimBrinkMD @MatthiasNahrend @SwirskiLab @mghradchiefs @UCSFimaging
Does gadolinium deposition in the brain have clinical consequence? Lessons from animal studies. doi.org/10.1148/radiol… @radiology_rsna @MGHImaging @MGHCSB @i3MGH @MGH_RI @MGHNeuroRad
A more powerful molecular MRI agent (4-10X higher than conventional MRI agents) to report on myeloperoxidase activity, which reflects oxidative stress and damaging inflammation. doi.org/10.1021/acs.jm…. @MGHImaging @MGHCSB @MGHNeuroRad @harvardmed @MGH_RI @JMedChem
Novel Coronavirus: What Neuroradiologists as Citizens of the World Need to Know ajnr.org/content/early/… @AJNR @MGHCSB @i3MGH
A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales thno.org/v09p7525.htm #Theranostics @Theranostics_J @i3MGH @MGHCSB @MGHImaging @MGH_RI @MGHNeuroRad
An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo pnas.org/content/116/24… @PNASNews @MGHCSB @MGHImaging @i3MGH @MGH_RI @MGHNeuroRad
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