Born Fabulous Podcast @PodcastBorn

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Scientists say the human brain may be salvageable for hours (and possibly days) after death. Death may no longer be an irreversible end, as pioneering research suggests the human brain remains salvageable and potentially revivable for hours or even days. Dr. Sam Parnia, an associate professor at NYU Langone Medical Center, is challenging the age-old assumption that death is a final, fixed state. After three decades of intensive research, Parnia argues that death should instead be viewed as a treatable injury. His team’s work has revealed that brain activity and even memory can return in patients long after their heart has stopped beating, suggesting the biological window for revival is significantly wider than the current medical standard dictates. This shift suggests that the transition to death is a manageable process rather than a sudden, permanent event. To push these boundaries, researchers are utilizing advanced interventions such as ECMO machines and specialized "CPR cocktails"—drug mixtures designed to protect the brain and optimize resuscitation. Parnia’s studies indicate that signs of cognition can persist even after clinical death, moving the concept of reanimation from the realm of science fiction into a tangible clinical possibility. By refining the tools and timing of medical response, this radical shift in perspective could redefine the very boundary between life and death, offering hope for recovery in cases previously deemed hopeless. source: Parnia, S. (2025). Sam Parnia: The doctor who thinks death is reversible. The Telegraph.

GOP Rep. Thomas Massie: “I think it's ironic that we control the House, Senate, Supreme Court, and the White House, and we're yelling 'election fraud'? I mean, we won all the damn elections."

@DemocraticWins @usamattersmedia

BREAKING: In a stunning moment, Fox News just admitted that Donald Trump is responsible for inflation being at its highest levels in over 3 years. Woah.

I'm a cardiologist. For months I've been telling you that inflammation is the fire behind heart disease — not just cholesterol. That we've been treating the smoke while the fire kept burning. Penn Medicine just built the fire extinguisher. They took the most powerful immune technology in cancer medicine — CAR T-cell therapy — and flipped it. Instead of engineering killer cells to destroy tumors, they engineered regulatory T cells to suppress the chronic arterial inflammation that causes heart attacks. Published in Circulation. The results stopped me cold. In CAR T cancer therapy, doctors extract your T cells, genetically engineer them to recognize a specific target, and infuse them back into your body as precision-guided missiles. It has cured previously terminal blood cancers. The technology won its developers a Nobel Prize. The Penn team asked a question no one had asked before: what if we aimed this at the arteries? They engineered regulatory T cells — Tregs, the immune cells whose job is to calm inflammation rather than cause it — to specifically target oxidized LDL. OxLDL is the molecule that starts the entire atherosclerotic cascade. It infiltrates your artery wall, triggers macrophages to gorge on it and become foam cells, releases inflammatory cytokines, recruits more immune cells, and builds the plaque that eventually ruptures and causes a heart attack. OxLDL is the match that lights the fire. These engineered CAR Tregs are designed to find that match and snuff it out — at the arterial wall itself. The results in mouse models of atherosclerosis: Blocked macrophage foam cell formation — the cellular process that builds plaque. Dramatically reduced arterial wall inflammation. Prevented over 70% of plaque buildup compared to untreated controls. And critically — preserved normal immune function everywhere else. That last point is essential. Previous anti-inflammatory approaches to atherosclerosis failed because they suppressed the entire immune system — leaving patients vulnerable to infections and other complications. Colchicine works modestly. Canakinumab in the CANTOS trial reduced events but increased fatal infections. The immune system is a sledgehammer. You can't just turn it down globally. CAR Tregs solve this by being targeted. They don't suppress your whole immune system. They patrol your arteries specifically, calming the inflammation at the exact site where it's causing damage — and leaving the rest of your immunity intact. One infusion. Targeted. Precise. The cells do the work. Lead author Robert Schwab of Penn Medicine put it directly: "If we can get the immune system to see OxLDL and provoke an anti-inflammatory response, it would reduce inflammation and essentially stop the pathogenesis in its tracks." Senior author Avery Posey: "Our study shows for the first time how CAR T cell technology could be used to treat the underlying cause of the most common form of heart disease — the leading cause of death worldwide." As a cardiologist who has spent twenty years treating the downstream consequences of arterial inflammation — the stents, the bypasses, the cardiac rehab, the second heart attacks — I need you to understand what this represents. Every treatment I currently have manages the damage after the fire has burned. Statins lower the fuel supply. Blood pressure meds reduce the mechanical stress. Stents prop open arteries that have already narrowed. These save lives. I use them daily. But none of them put out the fire itself. CAR Tregs are engineered to extinguish the inflammation at its source — inside the artery wall — before the plaque builds, before the vessel narrows, before the rupture, before the heart attack. This is the shift from managing disease to correcting the biological process that causes it. At the cellular level. With living medicine. This was demonstrated in mice, not humans. The leap from mouse models to human cardiovascular trials is enormous and filled with failures. Manufacturing CAR T cells is currently expensive — roughly $400,000 per treatment in cancer. Scaling this for a disease that affects billions would require a manufacturing revolution. Long-term safety of engineered immune cells patrolling human arteries for years or decades is completely unknown. Human trials are likely years away. But 70% plaque reduction. With preserved immune function. Targeting the exact inflammatory mechanism I've been writing about for months. Published in Circulation — the flagship journal of the American Heart Association. The trajectory is unmistakable. Gene editing to permanently lower cholesterol. Personalized mRNA vaccines to hunt cancer. GLP-1 drugs rewiring metabolism. Cellular reprogramming to reverse aging. And now — living immune cells engineered to extinguish the inflammation that causes the number one killer on earth. Every one of these treats the root cause instead of managing the downstream damage. Every one of them was impossible a decade ago. Every one of them is in trials or approaching trials right now. I've held dying hearts in my hands in the cath lab at 3 AM. Hearts that were destroyed by inflammation I could see but couldn't stop. The day I can infuse a patient with cells engineered to stop that inflammation before it ever builds the plaque — that's the day cardiology changes forever. We're not there yet. But the fire extinguisher just passed its first test.

I'm a cardiologist. A woman loses her husband. Two days later she's on my cath lab table — chest pain, EKG changes, enzymes elevated. Everything says heart attack. I thread the catheter. Her arteries are pristine. Her heart didn't clog. It shattered. From grief. Takotsubo — broken heart syndrome. Stress hormones stun the ventricle so severely it balloons and stops pumping. 90% of cases are women. Your heart can literally break. Not a metaphor. Physiology. But this is just one blind spot in a system built for men's hearts. Women get microvascular disease — plaque in vessels too small for angiograms to see. Heart attacks with "clean" arteries. Women get SCAD — leading cause of heart attack under 50. Most doctors have never diagnosed one. Women present with fatigue, jaw pain, nausea, back pain. Medicine called these "atypical" for decades. They're not atypical. They're female-typical. Half of humanity is not a variant. Heart disease kills more women than every cancer combined. Fewer than half know. Three things every woman needs to hear: Say these exact words to your doctor: "I am concerned this could be my heart." That sentence changes everything. Don't soften it. If tests are "normal" but symptoms persist — demand CT angiography or cardiac MRI. If you had preeclampsia — your cardiac surveillance starts now. Not at 65. Your heart can break from grief, from stress, from a system that wasn't built to see you. It can also heal. If someone finally looks. Share this with every woman you love.

Jennifer Doudna won the Nobel Prize for gene editing and went on Bloomberg to say the chatbots everyone is betting on cannot innovate at all. Every promise Silicon Valley is making about AI curing disease just hit the one person qualified to check it. She has spent her whole career inside the actual frontier of curing disease. So when she talks about what AI can and cannot do in biology, she is not guessing. She is reporting from inside the lab. Her words were blunt. She is not seeing chatbots innovate. They summarize data. They write reports. They do not come up with a brand new idea nobody has ever had. Then the interviewer pushed. So you're saying AI can't innovate? Doudna did not flinch. She does not know if it can't. She just does not see it doing it right now. This lands harder when you remember who is making the opposite case. Sam Altman says AI will eliminate disease within five years. Larry Ellison says AI will cure cancer in a 48 hour window. An OpenAI executive even floated that the company should get a cut of sales on any drug discovered through ChatGPT. Doudna answered that in two words. Good luck. Even the cancer specialists Altman is selling to keep warning that cancer is not one disease but hundreds, each needing its own cure, and that compute does not skip the years of lab work. Her reason is simpler. Biology is hard. You cannot simulate your way to an understanding of the human body. The people promising cures are the ones selling the tool. The person who actually won a Nobel building them is telling you it has not happened yet. Source: Bloomberg Originals Watch the full video on their official channel.

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I'm a cardiologist. After 40, stop guessing about your health. These numbers tell you whether you're building a long, vibrant life — or quietly declining without knowing it. I run these on myself. I run them on every patient I care about. Most are cheap bloodwork. All are available now. And together, they paint a picture no standard annual physical will ever give you. Print this. Bring it to your next appointment. Your 60-year-old self will thank you. ꟷꟷꟷ 𝗙𝗮𝘀𝘁𝗶𝗻𝗴 𝗜𝗻𝘀𝘂𝗹𝗶𝗻 Target: below 5 μIU/mL. Ideal: 3-4. This is the 10-year warning bell your standard panel completely misses. Your glucose and A1c can look "normal" for a decade while your pancreas is working overtime to keep them there. Fasting insulin catches insulin resistance 5-10 years before your A1c moves. By the time A1c rises, the damage is already extensive. 𝗛𝗢𝗠𝗔-𝗜𝗥 Target: below 1.0. Calculated from fasting insulin and fasting glucose. The single best measure of insulin sensitivity. Above 1.0 and your metabolism is already under strain. Above 2.5 and you're insulin resistant — even if every other number looks fine. 𝗛𝗯𝗔𝟭𝗰 Target: below 5.4%. Not below 5.7% — that's the threshold where medicine calls you "prediabetic." By then you've been metabolically compromised for years. Optimal is below 5.4%. Blood sugar mastery is longevity mastery. 𝗧𝗿𝗶𝗴𝗹𝘆𝗰𝗲𝗿𝗶𝗱𝗲 : 𝗛𝗗𝗟 𝗥𝗮𝘁𝗶𝗼 Target: below 2. Ideal: below 1. Your metabolic health crystal ball. This ratio predicts insulin resistance, cardiovascular risk, and metabolic syndrome better than any single lipid number alone. A ratio above 3.5 is a red flag regardless of what your total cholesterol says. 𝗔𝗽𝗼𝗕 Target: below 80 mg/dL for moderate risk. Below 60 for high risk. I've written about this extensively. ApoB counts every atherogenic particle hitting your artery walls. A 2024 analysis found 54% of patients had dangerous levels that standard LDL testing completely missed. If you only know your LDL, you're driving with one eye closed. 𝗟𝗽(𝗮) Test once in your lifetime. 100% genetic. 1 in 5 Americans are elevated. Triples heart attack risk independently of everything else on this list. Diet and exercise cannot lower it. The 2026 ACC/AHA guidelines now recommend everyone be tested. Most never have been. 𝗵𝘀-𝗖𝗥𝗣 Target: below 1.0 mg/L. You can have perfect cholesterol and inflamed arteries silently preparing to rupture. hs-CRP measures the fire behind the plaque. The JUPITER trial proved that finding and treating inflammation saves lives — even when lipids look fine. If this number is elevated, your mouth, your gut, your metabolic health, and your visceral fat are the first places to investigate. 𝗩𝗶𝘁𝗮𝗺𝗶𝗻 𝗗 Target: 50-80 ng/mL. Not the bare minimum of 30 your doctor accepts. Suboptimal vitamin D is linked to higher inflammation, weaker immunity, increased cardiovascular events, worse mood, and poorer outcomes across nearly every disease I treat. Supplement D3 with K2 — without K2, calcium deposits in your arteries instead of your bones. 𝗧𝗲𝘀𝘁𝗼𝘀𝘁𝗲𝗿𝗼𝗻𝗲 (𝗧𝗼𝘁𝗮𝗹 + 𝗙𝗿𝗲𝗲) Men: optimal range 600-1000+ ng/dL total. Declining testosterone is an independent predictor of cardiovascular death in men. It's tied to insulin resistance, arterial stiffness, visceral fat accumulation, and systemic inflammation. DHEA-S drops 10-20% every decade after 30. Tracking these isn't about vanity — it's evaluating your body's systemic resilience. 𝗕𝗹𝗼𝗼𝗱 𝗣𝗿𝗲𝘀𝘀𝘂𝗿𝗲 Target: below 120/80. Aim closer to 110/70. Every point above optimal is cumulative arterial damage. Buy a home cuff. Measure morning and evening, seated quietly for five minutes, arm at heart level. White-coat readings in the office miss what's really happening. The smartest $40 investment in cardiac self-care. 𝗩𝗢𝟮 𝗠𝗮𝘅 Men over 40: above 40 mL/kg/min. Women over 40: above 35. Cardiorespiratory fitness is the single strongest predictor of all-cause mortality — stronger than smoking, diabetes, or heart disease as individual risk factors. A landmark study in JAMA found that extreme fitness was associated with the lowest mortality with no upper limit of benefit. You can estimate VO2 max with a timed mile, a rower test, or a wearable. Get faster every year. 𝗡𝘂𝗺𝗯𝗲𝗿 𝗼𝗳 𝗠𝗲𝗱𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 Target: as few as possible. Every medication you're on should be earning its place. I just wrote about five commonly prescribed drugs that do more harm than good with long-term use. Bring your full medication list to every appointment. Ask: "Do I still need this?" Deprescribing is one of the most powerful and underused tools in medicine. ꟷꟷꟷ Thirteen numbers. Most available through cheap bloodwork and simple tests. Get them once or twice a year. Here's what I want you to understand: these numbers don't just tell you where you are. They tell you where you're heading. A fasting insulin of 8 today becomes diabetes in five years. An ApoB of 120 today becomes a heart attack in ten. An hs-CRP of 3 today means your arteries are inflamed right now — regardless of how healthy you feel. The standard annual physical checks a fraction of these. It was designed to find disease that's already there. This panel finds the disease that's coming — years before it arrives. What gets measured gets improved. Optimize with the foundation I write about every week on this platform: Zone 2 cardio plus resistance training 3-4 times per week. High-protein whole-food nutrition. Sleep 7-9 hours — non-negotiable. Morning sunlight. Stress management. And the targeted supplements I've covered in detail — creatine, magnesium, CoQ10, D3+K2, glycine, omega-3, psyllium husk. The breakthroughs coming in the next decade — gene editing for cholesterol, cellular reprogramming, senolytics that clear senescent "zombie" cells driving inflammation and aging, GLP-1 drugs rewriting metabolic medicine — will be most powerful for people who've already built the metabolic foundation to receive them. The future of medicine is personalized. But it starts with knowing your numbers today. Print this list. Book the bloodwork. Own the data. Prevention isn't passive. It's the most aggressive thing you can do for the decades ahead.

Turns out following science is … good for national security

Jesse Rodriguez @JesseRodriguez

5 days ago

Air Force quietly brings back flu vaccine rule for recruits after more than 200 fall sick at base

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23 years old and free of the disease he was born with. CRISPR switched his own cells back to making the hemoglobin he made as a baby, the kind that does not sickle. No more pain crises. No more transfusions. As a doctor I stay careful with big words, but moments like this are exactly why I went into medicine.

FearBuck @FearedBuck

6 days ago

Daniel Cressy, 23, becomes the first person in Louisiana to be functionally cured of sickle cell disease through gene therapy

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One billionaire family controls the bridge that carries 25% of all U.S.–Canada trade. The good news? There's a brand new public bridge right next door (and Canada paid for the whole thing). The bad news? Donald Trump won't let it open. Here's the story: For more than a decade, Michigan and Canada worked together to build a new public crossing right next to it — six lanes over the Detroit River, named for a Canadian-born Red Wings legend, built by thousands of union workers. Canada paid the entire bill. Michigan co-owns it. It's finished. It’s a shining example of international cooperation and collaboration, with a tremendous return for both sides: more jobs, faster trade, and lower costs. So why isn't it open? Because the Moroun family, who own the rival Ambassador Bridge just up the river, doesn’t want the competition. They spent years and tens of millions of dollars trying to stop any competing international crossing from being built or opening. They lost. So they went to the White House instead. In January, Matthew Moroun gave $1 million to a pro-Trump super PAC. Then the billionaire called Trump's Commerce Secretary and, just hours later, Trump suddenly attacked the same publicly owned bridge he praised in his own first term and threatened to block it. Then, the day before the June 12th ribbon-cutting, the opening was called off indefinitely. It's corruption so flagrant it would be laughable if it weren't so damaging. Trump is screwing over Michiganders for the interests of billionaires — holding a finished, publicly owned project hostage to protect one donor's toll booth. So a finished bridge sits closed, Michiganders keep paying the higher tolls, cars and trucks cost more, and a billionaire family keeps its monopoly. Mr. President: stop playing games. Open the damn bridge.

The Only 4 Kettlebell Moves You Need To Build Strength After 50 (Pavel Method)

Your Apple Watch + Welltory = science-backed insights The only app with its own research, proven to lower stress & boost life quality. Thousands of 5⭐ reviews say it works. Install now

This is one of the most scientifically dense conversations we have ever recorded on brain health, cholesterol, and Alzheimer's prevention. We get into why the phospholipid form of DHA reaches the brain when standard fish oil does not, how ApoE4 carriers burn through omega-3s, the lithium orotate data that emptied supplement shelves, why GSK-3 beta may be the most underrated target in Alzheimer's research, what seven years of 700+ cholesterol did to @nicknorwitz arteries, why the EZPAVE headlines fall apart under scrutiny, and what GLP-1s are doing inside the brain that has nothing to do with weight loss. Here's our full conversation: The ApoE4 Paradox and the Case Report That Broke the Internet Why Standard Omega-3 Supplements Fail and What to Take Instead DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic Why ApoE4 Carriers Burn Through DHA Faster and Need More Women, Omega-3s, Menopause, and Brain Insulin Resistance Statins, Sex Differences, and the DHA-Blood Sugar Connection Statins and Dementia: What the Data Actually Say Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance Gene Editing, Prime Editing, and the Future of ApoE4 Therapy 700 LDL, Zero Plaque, and Seven Years of Data Why the EZPAVE Headlines Don't Hold Up KetoneIQ: Ketones for Brain Energy and Focus Cheers Health: Supporting Liver Function and Cognitive Recovery If Not LDL, What Causes Heart Disease? The Oreo Experiment and the Sardine Diet Ketones, Women's Brains, and Clearing Misfolded Proteins The Full Brain Health Protocol GLP-1s for the Brain Peptides: What's Worth Watching Why Nick Is Controversial And Why He Doesn't Mind

I started my new job last week! I'm excited to be covering TX politics for @HoustonChron and other Hearst newspapers! My first story is below, exploring how anti-abortion policy in TX is evolving — and what that means for families around the state. houstonchronicle.com/politics/texas…

A covid vaccine study that the CDC halted over methodological concerns was published in a leading medical journal. It found that the vaccine reduced the risk of emergency room visits and hospitalizations among healthy adults by about half last winter. wapo.st/4uTHf2C

Dr. Jack Kruse just said AirPods are the stupidest thing people willingly wear today. Kruse is a neurosurgeon who says wireless earbuds deliver RF radiation directly into your ear canal, inches from your brain. Danny Jones said he switched to wired earphones because he knew this. Kruse told him that's not much better. "That's not good because you're still getting jump conduction into your ear." He says the science on the dangers of this has existed since 1977. Dr. Robert Becker, a scientist twice nominated for the Nobel Prize, went on 60 Minutes and told the world that all wireless technology has biological effects. He was cancelled for it. "All of this has biologic effects. I don't care what it is." Kruse says non-native EMF—wireless technology, blue light screens, RF microwaves—destroys your dopamine reward pathways and degrades your biology from the inside out. And yet, 280 million Americans wear wireless earbuds. Most of them have never been told what it's doing to the tissue inches from their brain. — Dr. Jack Kruse (@DrJackKruse) on the Danny Jones (@JonesDanny) podcast

Wireless Warrior @Anti5GWarrior

2 weeks ago

@marekszubart Short video about what you're doing to yourself with wireless gadgets: childrenshealthdefense.org/emr/wireless-a…

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🚨 BREAKING Scientists have silenced the most common genetic driver of Parkinson’s in living humans for the first time — reducing the harmful protein by up to 59%. This is the first antisense oligonucleotide (ASO) therapy for PD with human safety data. Thread 🧵👇 #Parkinsons #GeneTherapy