Dr. Rebecca Walker @RebLWalker
Computational Biologist | Former IBD + microbiome Postdoc @TheXavierLab @Broadinstitute | Bioinformatics PhD + neuropsychiatric genomics @GeschwindLab @UCLA Seattle, WA Joined November 2018-
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1/ Keen to share the story of my postdoc research in @TheXavierLab! We built a massive resource characterizing the spatial landscape of the gut, and yes, we dug deep into the biology too. If you’ve got a minute, let me walk you through the story. 🧵👇 nature.com/articles/s4158…
@tanyaphung Check the psychENCODE portal
Excited to share our latest study uncovering gut microbes and microbial metabolites linked to cardiovascular health! We show that Oscillibacter is associated w/decreased cholesterol in human subjects & that these bacteria take up &metabolize cholesterol. bit.ly/4cGpnjW
Human lectins a part of our innate immune system, they influence the #microbes that live in us. What species do they bind? @KiesslingGroup @TheXavierLab @ejalm developed Lectin-Seq as a method to mine the human #microbiome. Excited to share the strategy:science.org/doi/full/10.11…
Our latest preprint, profiling gene regulation in >670 developing human brains! Driven by exceptional PhD student @cindywen2019 "Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain." medrxiv.org/content/10.110…
Excited to share a pre-print of our work in the @KiesslingGroup describing interactions between human lectins and stool microbiota. Some highlights below: (1/4) x.com/biorxivpreprin…
Lectin-Seq: a method to profile lectin-microbe interactions in native communities biorxiv.org/cgi/content/sh… #bioRxiv
Ever wondered how oral microbes colonize the gut? Turns out gut inflammation opens up a niche Veillonella can exploit through nitrate utilization. Congrats to @DanielRojas150 and the team for all the help @emilytemple_ @monyekaba1 @Ahmedbiooo @RebLWalker nature.com/articles/s4156…
Congrats @DanielRojas150 @ericmichbrown !! Happy to be a (small) part of this work
Check out our study in @NatureMicrobiol describing how oral microbe #Veillonella parvula switches its metabolism to utilize inflammatory nitrate & colonize the gut. nature.com/articles/s4156…
Congrats Thomas!
Among billions of potential microbiome epitopes hide few immunodominant 'keystone' epitopes recognized by T cells. Out today in @ImmunityCP, we discover keystone epitopes and show T cell responses to reflect intestinal immune health. cell.com/immunity/fullt…
Check out my latest work exploring the gut microbiome of the Framingham Heart Study participants
Out now in @GenomeMedicine! Read about our latest efforts, led by @RebLWalker, exploring associations between diet, lifestyle, & cardiometabolic disease phenotypes w/the gut #microbiome among the @FraminghamStudy participants. genomemedicine.biomedcentral.com/articles/10.11…
Super excited to be able to share this study on gut microbiome ADP-ribosyltransferases and their role as phage-encoded fitness factors in the gut. Been a great collaboration with @HASCiencia and @Novartis along with @broadinstitute @MGH_RI & @emilytemple_ cell.com/cell-host-micr…
Examination of gene co-expression network architecture in human brain samples from @GTExPortal ; new from @GeschwindLab and colleagues go.nature.com/3iBPvkL
Multi-omic profiling in IBD patients initiating biologic therapy identifies remission-associated gut microbial features. Our findings provide a foundation for more individualized selection of optimal therapeutic agents. Online now @cellhostmicrobe: sciencedirect.com/science/articl…
A comprehensive, integrated review of unconventional T cells- excellent stuff from @TouficMayassi- nature.com/articles/s4158…
We are excited to share work by @johannesfscheid, @cobarnes27, and @basak_ersln with @bjorkmanlab, Regev lab, and @PaulBieniasz lab characterizing B cell responses against #SARSCoV2. (1/3) @broadinstitute Online @CellCellPress: cell.com/cell/fulltext/…
@chirag_msk @cancercell @GeneCollector @MingLiLab @arihakimi Congrats!!
In a collaboration with the Weersma lab out now in @NatureComms, we show that intestinal mucosa cis-eQTLs in IBD can depend on inflammatory status and be influenced by the cell type composition of the mucosa. Read about this work: nature.com/articles/s4146…
@goGUrtecho @HHMINEWS @harriswangnyc @srikosuri @GeiselBiofilm Congrats Guillaume!!
@kellyanneduncan @ShipraVaishnava Congrats!!
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