Ross Wilson @RossWilsonLab
CRISPR whisperer in perpetual training. We're working to enable safe & accessible delivery of genome editing therapeutics. @igisci @UCBerkeley https://t.co/89o53zRYUa Joined December 2019-
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Ross Wilson retweeted
🧬 Can CRISPR dial down α-synuclein instead of knocking it out? MTI winners Ross Wilson & Hanqin Li aim to halt Lewy bodies with precision base editing - $90 K + full platform support. #CRISPR #Parkinsons #MTIAwards 🔗 Read more at moleculartherapeutics.org/2026-mti-parki…
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Ross Wilson retweeted
Inaugural post! (after a long hiatus) Last May I quit my job to build @dittobio with @Mezarque and @emilycpierce ! We turn parasite molecules into drugs for autoimmune disease, and are part of the @ycombinator W26 batch. Thanks for betting on us @agupta
@Nicole_Paulk Nearly an hour? Tons of time to spare! 😅
Big news! Our team developed Neuro-PERC, a non-viral CRISPR delivery platform for genome editing of the brain. In our new preprint - bit.ly/NeuroPERC_pre - we report efficient editing in multiple models & species, including field-first results in large animals (pigs) 🧵👇
@jacksonlab @Mizzou Huge credit to @BrigetteManohar for leading this collaborative effort based at IGI & @berkeleyMCB, which would have been impossible without major contributions from OSU's @TNeuroSci_Lab @RussellLonser and support from NIH's SCGE consortium @somaticediting
@jacksonlab @Mizzou Together, these findings establish Neuro-PERC as a versatile, scalable, well-tolerated platform… as well as a promising candidate for clinical translation in neurotherapeutics. 🐭🐷🧠🧬✂️
@ScotWolfe1 @danielevanbauer @srishtiupasana Thanks to @GENbio for putting together a nice write-up on this work, which is available here: bit.ly/GEN-hiNLS We put our two favorite hiNLS constructs on @Addgene for anyone interested in giving them a try: addgene.org/search/catalog…
@ScotWolfe1 @danielevanbauer What did we see? • hiNLS constructs supported high yields • hiNLS can improve genome editing efficiency • this was true via 2 delivery methods: electroporation & PERC (peptide-mediated) • more NLS is better, but only up to a point Credit to T cell editor @srishtiupasana!
Cas9 gets an upgrade! Check out our new paper in The CRISPR Journal: bit.ly/hiNLS-Cas9 Eric Noel (who is on the job market!) created Cas9 constructs w/ nuclear localization signals (NLS) in the backbone, boosting genome editing activity in T cells. #CRISPR
Ross Wilson retweeted
New Strategy Enhances CRISPR Editing Efficiency for Therapeutic Use In a new April 2025 @CRISPRjournal published study, IGI @UCBerkeley researchers leverage new constructs for NLS sequences to improve editing efficiency in human immune cells #crispr hubs.li/Q03hZVqv0
@GENbio @CRISPRjournal @UCBerkeley Thank you for the lovely write-up!
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